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HEME Test 1 > Just Markers > Flashcards

Just Markers Flashcards

1
Q

t (14;18)

A

follicular lymphoma

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2
Q

t(8;14)

A

Burkitt’s

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3
Q

CD19+, CD10+, CD3-, CD15-

A

DLBCL

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4
Q

Waldeyer Ring

A

DLBCL

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5
Q

ringed sideroblasts, megaloblasts, abnormal

megakaryocytes, and myeloblasts in the marrow

A

myelodysplasia

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6
Q

5q marker

A

post therapy myeylodysplasia

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7
Q

AL amyloid,

A

MM

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8
Q

blasts

A

leukemic process

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9
Q

Interleukin-5

A

acts as an eosinophilic chemotactic factor to form an eosinophilic cellular component of the mixed
cellularity and nodular sclerosis types of Hodgkin lymphoma

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10
Q

t(15;17)

A

APL

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11
Q

CD19+ and CD20+, but CD3−.

A

MALT- MZL

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12
Q

Sézary cells

A

can be seen in peripheral T-cell lymphoma/leukemias, which often involve the
skin.

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13
Q

blasts are CD33+.

A

AML

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14
Q

Döhle bodies,

A

patches of dilated endoplasmic reticulum, and toxic
granulations, which are coarse and dark primary granules, are reactive changes in mature neutrophils most indicative of
marked inflammation, such as bacterial sepsis.

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15
Q

lesion involving the ileum.

A

Burkitt’s

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16
Q

CD5+

A

SLL, CLL

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17
Q

t(9;22)

A

BCR-ABL
= phili chromosome
CML

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18
Q

BCR-ABL

A

CML

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19
Q

clonal rearrangement of Ig genes

A

CLL

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20
Q

BCL2 overexpression

A

t14;18

FL

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21
Q

C-MYC overexpression

A

t8;14

burkitt’s lymphoma

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22
Q

High serum levels of IL-6

A

MM

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23
Q

stage I HL

A

single lymph node or organ involved

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24
Q

stage II HL

A

two+ lymph nodes involved on same side OR localized involvement of an extralymphatic site

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25
Q

stage III HL

A

lymph node involvement on both sides of diaphragm OR localized involvment of exralymphatic organ

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26
Q

stage IV HL

A

diffuse involvment of one or more extralymphatic organs or sites with or without lymphatic involvment

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27
Q

t(11;14)

A

mantle cell lympoma

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28
Q

cyclin D1

A

mantle cell lymphoma

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29
Q

BCL1 gene

A

mantle cell lymphoma

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30
Q

CD15+

A

RS cell - HL

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31
Q

“cloverleaf” cells.

A

HTLV-1, which can cause leukemia/lymphoma and demyelinating disease

32
Q

CD68

A

Sinus histiocytosis represents an immunological response

to cancer antigens.

33
Q

CD19, CD20, and CD11c

A

HCL

34
Q

Teardrop RBCs

A

misshapen RBCs that are seen when marrow undergoes

fibrosis

35
Q

BCL6

A

DLCL

36
Q

NOTCH1

A

TALL

37
Q

22q11.2

A

DiGeorge anomaly - patients lack thymus and T cells

38
Q

t(15;17)

A

APL

39
Q

CD15+

A

HL, see RS cells and lacunar cells

40
Q

atypical lymphocytes

A

infectious mononucleosis

41
Q

Anaplastic lymphoma kinase protein

A

most often appears in
children and young adults. It is often extranodal and has a characteristic gene rearrangement on chromosome 2p23 that
results in production of anaplastic lymphoma kinase (ALK) with tyrosine kinase activity.

see ulcerated nodules

42
Q

deletions of 5q

A

MDS

43
Q

CD15+, CD30+

A

HL

44
Q

binucleated cells

A

think HL!

45
Q

auer rods and t(8;21)

A

AML with myelocytic maturation

46
Q

t(15;17)

A

acute promyelocytic leukemia (APL)

47
Q

inv(16)

A

AML with myelmonocytic maturation (AMML)

48
Q

TdT

A

ALL: seen only in pre-B and pre-T cell lymphocytes

49
Q

PAX5

A

ALL

50
Q

RUNX1 and ETV6

A

BALL

51
Q

t(12;21)

A

BALL

52
Q

Smudge cells

A

CLL/SLL

53
Q

HTLV1

A

Adult T-cell leukemia/lymphoma

54
Q

HHV-8

A

“KSHV/HHV-8” – associated with unusual B-cell lymphoma that presents as a malignant effusion, often in the pleural cavity

55
Q

CD138+

A

MM

56
Q

syndecan -1

A

CD138+ MM

57
Q

CD56+

A

MM

58
Q

rearrangements involving IgH, 13q deletions?

A

MM

59
Q

MYD88

A

LL

60
Q

BCL fusion genes

A

MZL

61
Q

BRAF

A

HCL

62
Q

monoclonal IgM spike?

A

lymphoplasmacytic lymphoma –> hyperviscosity syndrome

63
Q

CD11c

A

HCL

64
Q

Rouleux formation

A

MM

65
Q

annexin A1

A

HCL

66
Q

just CD30+

A

ALCL

67
Q

CCR4

A

mycosis Fungoides

68
Q

CCR10

A

Mycosis Fungoides

69
Q

CD103

A

HCL

70
Q

STAT3

A

large granular lymphocytic leukemia

71
Q

CD15+, CD30+

A

mixed cellularity HL

72
Q

+CD20, CD15-, CD30-, EBV-

A

lymphocyte predominance HL

73
Q

CD34, CD33

A

AML

74
Q

JAK2

A

think PCV, or Essential thrombocytosis

75
Q

S-100+, CD1a+ and HLA-DR+

A

Langerhans cell hystiocytosis

HEME Test 1 (6 decks)

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