Joven Médico Analgésicos

Question 1

What is the therapeutic class of Paracetamol?

Answer 1

Analgesic; antipyretic

Paracetamol is commonly used to relieve pain and reduce fever.

Question 2

What is the pharmacological class of Paracetamol?

Answer 2

Inhibitor of cyclooxygenase (COX)

Paracetamol specifically inhibits certain enzymes involved in pain and fever pathways.

Question 3

What is the mechanism of action of Paracetamol?

Answer 3

Selective inhibition of COX-3 isoenzyme, with minimal effect on COX-1 and COX-2; inhibition of prostaglandin synthesis

This leads to reduced pain and fever.

Question 4

What is the clinical use of Paracetamol?

Answer 4

Treatment of mild to moderate pain and fever

It is widely used for various types of pain relief.

Question 5

What special considerations should be noted regarding Paracetamol?

Answer 5

Lacks anti-inflammatory activity and anti-platelet effects; Category A in pregnancy

It is safe for use during pregnancy.

Question 6

What are the common adverse effects of Paracetamol?

Answer 6

Normally none; overdose can cause fatal liver failure

Treatment involves acetylcysteine to replenish depleted sulfhydryl groups.

Question 7

What interactions should be considered with Paracetamol?

Answer 7

Increased hepatotoxicity with chronic alcoholism; additive renal toxicity with salicylates and other NSAIDs

Alcoholism can enhance the risk of liver damage.

Question 8

What is the recommended dosage of Paracetamol for adults?

Answer 8

500 to 650 mg every 4 to 6 hours or 1000 mg every 6 hours

Dosage may vary based on specific needs and medical advice.

Question 9

What is the recommended dosage of Paracetamol for children?

Answer 9

10-15 mg/kg/dose every 6 hours

Care must be taken to adjust the dose according to the child’s weight.