Joint Conditions Flashcards

1
Q

What type of cell is found in acute joint conditions?

A
Polymorphonuclear leucocytes (polymorphs)
Called such because their nuclei are in many sections and appear white under microscopy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What type of cell is found in chronic joint conditions?

A

Lymphocytes

Produced in the bone marrow and the spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the main aim of treatment of OA?

A

To relieve pain and stiffness, since many joint conditions are incurable and will inevitably get worse with time

(examples of self-limiting MSK conditions: muscle tears, ligament sprains)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Example of a metabolic disorder which can lead to joint inflammation?

A

Gout - inflammation caused by aric acid crystal deposition on the cartilage, which is a waste product of DNA metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name the 2 principal symptoms in orthopaedics?

A

Pain and Stiffness (leading to loss of normal function of joints)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What does ‘orthopaedics’ mean?

A

Literally ‘straight children’ as it used to deal with abnormalities of children as they grow and develop, but now deals with the MSK system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is osteoarthritis?

A

A condition of pain and limitation of movement of joints assoc w excessive wear of articular cartilage resulting from a breakdown of balance between wear and repair processes in the joint. It is more common with increasing age, but does not inevitably accompany old age.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is primary OA?

A

When there is an imbalanced wear and repair mechanism on the articular cartilage, but no other secondary condition causing the damage. More often it is a problem with increased wear.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is secondary OA? 6 Causes?

A

Obvious causative factors which can be assumed responsible for causing OA:

  • Congenital - congenital dislocation of the hip
  • Childhood - Perthes’ Disease (compromised blood supply to femoral head causing AVN)
  • Trauma (e.g. fracture)
  • Metabolic (gout, crystal arthropathy)
  • Infection (septic arthritis, TB)
  • Chronic inflammation (rheumatoid)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Hx of osteoarthritis?

A

Joint pain assoc w activity followed, and for <30min in morning

Stiffness follows pain

Can often feel tired due to excess effort required to move and disturbed sleep due to pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Examination of OA?

A

There is pain and limited range of movement during examination of the joint. Muscle wasting may be present due to disuse.

If examining under anaesthetic there is an increased range of motion, therefore results of surgery related to pain relief rather than improved mobility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Conservative treatment options for OA?

A

Weight loss

Walking stick

Rest & Physio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How does weight loss help in OA?

A

Lower limb joints are subject to very large loads due to leverage exerted by muscles around the joints - when walking the hip is subject to 3x body weight during the stance phase, and during activities of greater hip muscle exertion joint load can reach 5x body weight. Therefore, modest reductions in body weight lead to large reductions in force through the joints.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How does a walking stick help in OA?

A

Use of a stick in the opposite hand means the shoulder girdle can help in tilting the pelvis and so help in weight bearing. Normally when we walk, when we have our weight on the right side, the right gluteal muscles contract to tilt the left side of the pelvis upward, letting the left leg swing forward without making contact with the ground. The use of a stick has the effect of reducing the work required by the abductor muscles thereby dramatically reducing muscle induced loads on the hip.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How does physiotherapy help in OA?

A

Balance is required: over-exercise can be detrimental but some exercise allows relief from stiffness and muscle spasm, and therefore pain. Sufferers should be advised o avoid excessive unnecessary exercise and change to a light job if possible. Total rest, however, is counterproductive, especially in the elderly, because muscles work most efficiently when they are in regular use. Stretching them in exercise helps them maintain natural tone, whereas excessive rest around a painful joint will make the muscles go into spasm, which is painful and inhibiting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Surgical options for OA? (4)

A

Do nothing

Arthrodesis

Osteotomy

Arthroplasty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Considerations around NOT performing surgery in OA?

A

Risks may outweigh benefits

If severely disabled and in a great deal of pain, surgery may be considered, but only after careful planning and full explanation, and provided patient has a full grasp of the risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q
What is arthrodesis?
Who is it most useful for?
How is it done?
When might it be problematic?
Why is it difficult for the hip?
A

Surgical stiffening of a joint in a position of function - this is more appropriate for a young person with a painful joint with limited ROM.

Articular cartilage is removed and the raw bone ends are held together by an external splint until a bony bridge forms between the bone ends. In the hip this is usually done at 30 degrees flexion with slight adduction, allowing functional gait and sitting.

However, this is not always acceptable for females as it interferes with sexual activity.

Fusion is technically difficult in large joints such as the hip because the bones are difficult to hold together - the operation requires prolonged recovery of 6 months and often a plaster splint.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Long term disadvantage of arthrodesis?
How is this overcome?
Which joints is arthrodesis most successful in and why?

A

Long term disadvantage is that it puts stress on adjacent joints, e.g. for the hip this means the lumbar spine, knee and contralateral hip. This problem can be anticipated by electing to fuse e.g. until the 5th decade, then attempting to ‘unpick’ the fusion and convert to an arthroplasty, which is surprisingly effective.

Some joints can be very successfully fused, however, including the ankle and wrist. This is because they are small joints so easier to hold together, they don’t require a huge functional ROM, and because these joints are difficult to replace.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is osteotomy?
When is it used?
How long does it last?
How is it performed in the hip?

A

Surgical realignment of a joint - the aim is to redirect forces across a joint so they more evenly distribute the load, and is generally performed when the joint has become deformed e.g. if someone with rickets has become bow-legged the forces travel down the medial aspect of the knee joint rather than the centre.

It is useful in arthritis when the patient has retained a good ROM despite the pain, typical of early stage OA. Conversely, if the ROM is severely limited then a simple realignment is unlikely to succeed because useful function cannot be restored.

It is often a temporary measure, for any condition (arthritis, bow leg etc), lasting around 2-10 years, because the underlying cause of the problem may not have been tackled.

In the hip it can be performed on the pelvic side, by performing a shelf or total acetabular realignment, or on the femoral side by altering the angle of the femoral neck.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What does arthroplasty mean?

A

Replacement of one or both surfaces of a joint - it can alleviate pain and restriction of ROM, but will not help stiffness (due to greater coefficient of friction)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Why are joint replacements not permanent?

A

They are not live tissues, they are artificial, therefore have no capacity to regenerate, and from the minute it is first used it will begin to gradually degenerate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Why is joint replacement more difficult in the upper limb than the lower limb?

A

In lower limb joints, the loads are high and the functional ROM required is low.

In upper limb joints, the loads are not so high but the functional ROM required is high. Arthroplasty alleviates pain-related loss of function, but not stiffness, because the soft tissue distortion of the capsule and ligaments tends to remain after replacing the articular surface.

E.g. the elbow must flex to 90 degrees to eat and fully extend to reach anus for cleansing after defaecation, which is a demanding functional ROM, and the technology isn’t quite up to standard yet.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

3 requirements of an artificial joint?

A

Functional and pain free ROM

Withstanding the significant force placed on it without undue wear or working loose

Having the same stability and resistance to forces as the natural joint

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What ROM does the hip retain after an arthroplasty?

A

10-15 degrees Extension
30 degrees Flexion
A few degrees Abduction
A few degrees Rotation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Specific functional requirements of a knee replacement?

How is this achieved

A

It must flex to 90 degrees to ascend stairs, and must be stable in full extension to suport weight whilst standing on one leg.

To achieve this, there must be an accurate balance of soft tissues through dissection of the capsule and ligaments. The surgeon must balance the collateral ligaments by cutting tight parts and putting in artificial replacements of sufficient thickness to re-tighten the ligaments, so that medial and lateral are under equal tension. This is because bone erosion in OA leads to distortions in the ligaments (which further leads to deformities and pain of OA).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

4 potential complications for anyone undergoing any surgery?

A

Chest infection
UTI
Pressure Sores
DVT

(sores and DVT particularly with any pelvic surgery, hip replacement or knee replacement)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

3 specific early complications of arthroplasty?

A

DISLOCATION

DVT (and PE)

INFECTION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

2 specific late complications of arthroplasty?

A

Infection

Loosening and Wear

30
Q

Why is dislocation an early complication of arthroplasty?

Can it be a late complication?

A

The prosthesis will not be fully supported by the soft tissues immediately post-surgery, and the muscles and proprioceptors may be temporarily out of action through surgical trauma and analgesia. A capsule of scar tissue also will not yet have formed round the prosthesis, which would aid in stability. Therefore, dislocation is at particularly high risk before the effects of anaesthesia wear off.

However, even after years, injudicious moves such as twisting the leg into extreme flexion with adduction and internal rotation can result in painful dislocation. Therefore, advice may be required around dressing and having a raised toilet seat.

31
Q

Why is DVT an early complication?

Medical and non-medical prophylaxis methods

A

Instability, hyper coagulable state post-surgery and potential vessel wall damage (Virchow’s triad) lead to venous clots.

In the acute phase, drugs such as LMWH or LMWH or NOAC’s may be used, followed by prophylaxis with warfarin. However, regimens can change based on region.

Compression stockings are also used to try and minimise the risk of blood pooling in the legs, removing venous stasis as a risk factor.

32
Q

When is infection a risk for arthroplasty?
Why is it problematic?
What precautions are taken and how effective are they?
Why can infection develop late?

A

This is always a risk, early or late, and is generally from skin commensals such as staph aureus or staph epidermis (albus).

The body is unable to fight off an infection of a prosthesis since it is a foreign object, and therefore has no blood supply.

Techniques such as antibiotic prophylaxis and sterile operating fields are employed to minimise the risk. If all precautions are taken, then the risk of immediate infection should be eliminated and the risk of late infection should be 0.1%. However, the is rarely achieved, and unfortunately the infection rate can be as high as 3%.

It is not completely understood why some infections only become apparent late after the operation, but it is hypothesised that they may be a consequence of bacteraemia, similar to how strep viridians subacute infective endocarditis can occur after oral surgery.

33
Q

Why is loosening and wear a risk of arthroplasty?

A

It is inevitable through the passage of time. For this reason, alternative procedures and better materials must still be researched

34
Q

What is Rheumatoid arthritis?

A

A systemic disease of unknown cause. However, it has some clear links with abnormalities of the immune system and genetic mutations which cause an abnormal reaction to certain bacteria, which results in rheumatoid arthritis

35
Q

Where in the body does rheumatoid arthritis effect?
Who is most affected?
What symptoms will the pt complain of?

A

The small joints of the hand and feet are symmetrically affected first, however the DIP joints of the hand are always spared. This can sometimes progress to larger joints, which are not symmetrically affected. There is no known reason for this pattern.

As it is an autoimmune disease, women are more likely to be affected.

The patient first notices stiffness, worst in the morning and lasting >30 mins, and easing throughout the day (in contrast to OA where stiffness worsens after activity due to inflammation)

36
Q

General management of RA?

A

Generally a medical team, involving a rheumatologist who will prescribe analgesics and DMARDs to try and inhibit progression of the disease. If surgery is necessary, the surgeon aims to keep the patient as comfortable as possible whilst retaining as much function as possible.

37
Q

What soft tissue surgery may be performed in RA?

Who in particular is it useful for?

A

The disease may result in damage to the tendons and tendon sheaths. Damage can be limited by performing a SYNOVECTOMY. This is a good operation for clearing up damage around the extensor tendons at the wrist. Sometimes, tendons around the wrist actually rupture, requiring repair

Useful in younger patient who has pain but retains good ROM

38
Q

What joint surgery can be performed in RA?

What is the surgeon’s role?

A

At the elbow and wrist, a partial removal of the joint - excision arthroplasty - may be combined with synovectomy. This relieves pain but because some of the joint has been removed there can never be a full return of function.

Most of the surgeon’s role is salvage - the goal is pain relief and return of function, not reparation of deformity, as some patients may have very distorted hands but retain excellent function. Before surgery, the surgeon must ensure there is adequate drug control of the rheumatoid process.

39
Q

What is AVN?

A

Death of bone tissue through loss of blood supply - this can happen throughout the body spontaneously for no apparent reason, or can occur when there is a clear traceable cause

40
Q

Post -traumatic AVN:

  • where?
  • mechanism?
A

Areas at high risk:

  • femoral head
  • proximal scaphoid
  • proximal talus

In these situations, trauma cuts the blood supply. In femoral neck fractures, damage to the capsular blood supply puts the femoral head at risk, and at the other 2 sites a distal blood supply is severed from the proximal part of bone (i.e. retrograde blood supply)

41
Q

Non-traumatic AVN:

  • where?
  • causes?
  • symptoms?
A

This is common in the femur and the lunate.

AVN may occur in the femur as a result of alcohol abuse, high dose steroid therapy, and in deep sea divers (Caisson’s disease). The exact cause in these circumstances is unknown.

The patient presents with acute, often severe pain which is made worse with movement. With the passage of time, symptoms become indistinguishable from OA and may be treated as such. Unfortunately, many who suffer AVN are young.

42
Q

Diagnosis of AVN?

A

Can be difficult as there are no initial changes to XR. Later, the affected bone appears dense, reflecting the absence of blood vessels.

43
Q

Management of AVN?

A

When recognised early, core decompression can be employed, which involves drilling one larger, or several smaller holes into the femoral head to relieve pressure and promote revascularisation, which can sometimes prevent collapse of the femoral head and development of OA.

However, often this is not possible, and treatment is non-specific involving rest and analgesia. Often, joint replacement is necessary as the patients are young and tend to develop OA.

44
Q

What is the pathophysiology of gout?

Some precipitating causes?

A

Deposition of urate crystals, a waste product of DNA breakdown, on the surface of articular cartilage within the synovial fluid.

The commonest cause is overuse of diuretics, whilst other causes include dehydration (esp post-surgery), and after chemotherapy

45
Q

Presentation of gout?

A

Hot, tender, swollen joint. Any joint can be affected but it is most commonly the first MTP - important to exclude septic arthritis

46
Q

Diagnosis of gout?

A

Gold standard is by joint aspiration, whereby fluid is extracted from the joint to look for negatively-birefringent needle-shaped crystals under bipolar microscopy. Another, less specific and sensitive investigation is detection of uric acid levels in the blood.

47
Q

Treatment of gout?

A

Acutely with NSAIDs, colchicine or steroids. Prophylaxis with allopurinol or febuxostat

48
Q

What is pseudogout?

What can it cause long-term?

A

Deposition of calcium pyrophosphate crystals in joints, causing a presentation which mimics gout but is less acute. The origin of calcium pyrophosphate is unknown, and the crystals are positively-birefringent rhomboid shaped. It most commonly affects the menisci of the knee and may be controlled with NSAIDs, however long-term degeneration of the joint is likely

Long-term, it can cause calcification of the articular cartilage

49
Q

Complications of crystal arthropathies?

A

Chronic degenerative change (cause of secondary arthritis). They also cause acute inflammations, which tend to settle spontaneously, however are usually painful so treated with analgesics.

50
Q

Clinical presentation of septic arthritis in kids?

A

Very unpleasant illness where child is unwell with high fever. The affected joint is stiff, hot and tender.

51
Q

Cinical presentation of septic arthritis in adults?

A

Less acute - if a chronically abnormal joint it may give the impression of a minor upset. Patient remains unwell for many days before presenting with septicaemia - many die because of the delay in recognition

Rarely, young adults may present with septic arthritis, with little constitutional upset, caused by gonococcus

52
Q

Management of septic arthritis? Possible complication of treatment failure?

A

Surgery to wash out joint, and antibiotics based on cultures from surgery. The empirical antibiotic is usually flucloxacillin, as the most common organism is staph aureus, even in children.

Apart from septicaemia, if treatment fails then there is a risk the articular cartilage may disintegrate, leading to fibrous or bony fusion of the joint

53
Q

aetiology of chronic septic arthritis?

A

Joint TB results in chronic septic arthritis. Found world-wide though mainly in developing countries. AIDS patients are particularly prone to the illness. Spread to joint is haematogenous. Kidney and joint TB are often found together.

54
Q

Presentation and management of chronic septic arthritis?

A

Chronic ill health, weight loss and considerable muscle wasting around the joint. XR shows marked thickening of bone.

Treatment is by anti-TB drugs (RIPE), sometimes only rifampicin, ethambutol and streptomycin. SURGERY IS RARELY NEEDED (unlike other septic arthritis)

55
Q

4 common complaints of mechanical knee problems?

A

Swelling
Locking
Giving way
Pain

56
Q

Who are meniscal lesions more common in?

Symptoms?

A

Although seen in both sexes, more common in males, due to higher frequency of being involved in vigorous contact sports. Can uncommonly occur in children/adolescents who are born with an abnormal lateral meniscus.

Symptoms are pain, effusion and sometimes locking/giving way. The abnormality is poorly localised on examination, although general discomfort may be elicited by gently extending the knee.

57
Q

Principal mechanism of meniscal lesions?

A

Twisting injuries - often assoc w skiing or sports where studded boots are worn. In these scenarios, the foot gets stuck in the ground and the femur twists over the tibia, causing a wrench to the meniscus, which may be torn or pulled off the bone

58
Q

What meniscus is most commonly torn and what is the pattern of damage?

A

Medial meniscus

May be torn at peripheral attachment to the joint capsule or actually within its substance. The meniscus may split horizontally - a cleavage lesion - which is common in old age. Occasionally these cleavage lesions act like a flap valve and allow a build up of synovial fluid within the meniscus, forming a cyst

59
Q

3 common pathological tears of the meniscus?

A

Bucket handle tear - vertical split, which is anchored at both ends

Parrot beak tear - a split off one end of the lateral meniscus

Degeneratie tear - due to degeneration

60
Q

Management of meniscal tears?

A

Arthroscopy can be used once clinical suspicion in order to investigate.

As much as possible should be preserved to distribute load between tibia and femur. Peripheral tears can be reattached via sutures. Tears within the substance have no apparent capacity for repair so the torn peripheral part should be removed.

Most meniscal lesions can be removed via arthroscope, allowing quicker recovery, although some still require arthrotomy.

61
Q

Aetiology of loose bodies within the knee?

A

Osteochondral fragments may be sheared off in an injury, causing haemarthrosis. The osteochondral body is not absorbed but remains floating free in the synovial fluid. The bulk of loose bodies is cartilage so may not be visible on XR.

62
Q

Presentation of loose bodies?

A

The first incident may settle, but months-years later the patient presents with locking, pain and giving way, often with effusion

63
Q

Management of loose bodies?

A

Usually removal via arthroscopy

Very rarely, in adolescents, osteochondral bodies can occur spontaneously in a condition known as osteochondritis dissecans - this tends to resolve spontaneously but the loose bodies may require removal

64
Q

Difference between cruciate and collateral ligament injuries in the knee?

A

Collateral ligament injuries heal spontaneously as they have an excellent blood supply

Cruciate ligament tears are not capable of healing because they lose their blood supply if torn

(in rare circumstances, if the ligament is torn off with a fragment of bone at one end, if the bone is promptly put back within a few hours the whole ligament may survive with its blood supply relatively undamaged)

65
Q

Mechanism of cruciate ligament injuries?

A

Commonly hyperextension or twisting injuries, often assoc w the foot being anchored to the ground by a studded boot or ski

66
Q

Clinical presentation of cruciate ligament injury?

Chronic issues?

A

Acutely, very painful with rapid swelling from haemarthrosis and a ‘pop’ sound when it happens.

After a few weeks the swelling subsides and chronic issues arrise, such as AP instability (esp in flexion) and rotary instability (when twisting/turning), which particularly disabling for athletes. Some patients have no chronic issues and there is no explanation for why. Many only experience symptoms when ascending/descending stairs, or when twisting/turning.

67
Q

Management of cruciate ligament injury?

A

In general, the ligament should be left untreated for a while and the knee muscles rehabilitated. Treatment is only offered if it interferes with ADL’s or the pt wishes to return to sport.

Treatment consists of replacing the torn ligament with a synthetic one, which have an unknown lifespan as of yet, but may be more prone to failure as they have no sensory receptors (unlike the natural ligament) to inform the brain if the ligament is being overstretched. The brain is therefore unable to initiate muscle action to protect the joint.

68
Q

Aetiology of patellar dislocation?

A

Usually assoc with malformation of the patella or lateral femoral condyle, which leads to the patella moving abrasively on the femur (map-tracking), which is painful because of the associated muscle spasm

69
Q

Clinical presentation of patellar dislocation?

A

In some people, it leads to spontaneous dislocation and therefore failure of the quadriceps muscles to act as extensors, so the person falls to the ground. This can be very dangerous as it happens without warning

70
Q

Management of patellar dislocation?

A

In minor degrees of map-tracking, surgical splitting of the vastus lateralis insertion of the patella can be employed, allowing it to fall back into a normal relationship to the femur

If recurrent and severe, then PLICATION may be required - medial tightening of the vastus lateralis muscle. In adulthood, the patella may be sited more medially.

71
Q

What should mal-tracking and patellar dislocation not be confused with?

A

Anterior knee pain - condition in adolescent/teen girls, which is poorly understood and settles spontaneously with time