join Flashcards

1
Q
Antineutrophil cytoplasmic antibodies (ANCA)
Antiendomysial antibodies (AEA)
Antinuclear antibodies (ANA)
Anti-Saccharomyces cerevisiae antibodies (ASCA)
A

pANCA: UC, polyangitis
AEA, anti-gliadin: CEliAc sprue
ANA, anti-smith, anti-dsDNA: SLE
ASCA: Crohns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q
What examination finding would be expected in a patient with von Willebrand disease?
Gingival bleeding
Splenomegaly
Muscle weakness
Hemarthrosis
A

A patient with von Willebrand disease most commonly presents with mucosal bleeding seen in epistaxis, gingival bleeding, and menorrhagia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

established risk factor for osteoporosis

A
low body weight
female 
advanced age
Caucasian 
b/l ooph prior to menopause c/o estrogen replacement
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

52 year-old obese patient with persistent heavy menses undergoes an endometrial biopsy and is diagnosed with atypical adenomatous hyperplasia. What is the next step in the management of this patient?
Total abdominal hysterectomy
Observation and endometrial biopsy in 3 months
Endometrial curettage followed by progesterone daily
Oral progesterone days 16-25 of the month for 6 months and repeat biopsy

A

Atypical adenomatous hyperplasia contains cellular atypia and mitotic figures in addition to glandular crowding and complexity. This has a 20-30% risk of progression to endometrial cancer and the recommendation is hysterectomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

A 72 year-old male presents to the emergency department with crushing chest pain, dyspnea and palpitations for 2 hours in duration. Enzymes are pending and he has been given aspirin and sublingual nitroglycerin. He is rushed to the catheterization lab where they find a totally occluded distal right coronary artery. Which of the following electrocardiogram (ECG) findings supports the diagnosis?
Q waves in leads I, aVL, V5-V6
ST segment elevation in leads II, III, aVF
Hyperacute T waves in leads I, aVL
Flipped T waves with repolarization changes in leads V1-V4

A

ST segment elevation in leads II, III, aVF, represents an acute process in the right coronary artery.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q
A patient presents with occasional wheezing and chest tightness that occurs approximately once a week and at night only about once a month. Peak expiratory flow is 85% of predicted. Which of the following is the most appropriate initial treatment?
	Albuterol (Proventil) inhaler
	Montelukast (Singular)
	Salmeterol (Serevent) inhaler
	Sustained release theophylline
A

This patient has mild intermittent asthma which is initially treated with inhaled beta 2-agonists as needed. No long-term control medications are indicated.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q
Which of the following medications decreases the exchange of hydrogen for potassium by inhibiting hydrogen, potassium-ATPase?
	Ranitidine (Zantac)
	Misoprostol (Cytotec)
	Sucralfate (Carafate)
	Omeprazole (Prilosec)
A

Omeprazole, a proton pump inhibitor, works by inhibiting hydrogen, potassium-ATPase.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Who is most likely to require subacute bacterial endocarditis (SBE) prophylaxis prior to a dental procedure?
22 year-old female with mitral valve prolapse
36 year-old male with a bio-prosthesic mitral valve
45 year-old female with an ASD closure 8 months ago with no residual defect
15 year-old male with a bicuspid aortic valve

A

AHA recommends that patients with prosthetic heart valves receive antibiotic prophylaxis. As should cardiac transplant recipients with valve disease, unrepaired cyanotic CHD, repaired CHD with prosthetic material or device during the first six months of the procedure and repaired CHD with residual defects at site of patch or prosthetic device.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q
A 3 month-old male presents with two days of worsening hoarse cough and thick purulent rhinorrhea associated with increasing problems breathing and trouble feeding. Examination reveals a temperature of 100.2 degrees F and respiratory rate of 80/minute with nasal flaring and retractions. Lung examination reveals a prolonged expiratory phase with inspiratory rales. He is tachycardic. Pulse oximetry reveals oxygen saturation of 89%. Chest x-ray reveals hyperinflation with diffuse interstitial infiltrates. Which of the following is the most appropriate intervention?
	Antibiotics
	Hospitalization
	Inhaled corticosteroids
	Racemic epinephrine
A

most likely has bronchiolitis. While most cases are mild and can be treated at home, hospitalization is recommended for infants with hypoxia on room air, moderate tachypnea with feeding difficulties and marked respiratory distress with retractions. Additionally hospitalization is recommended for infants less than 2-3 months of age, a history of apnea or an underlying chronic cardiopulmonary disease.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

preterm labor may be given corticosteroids to ___________ for____ wks

A

enhance pulmonary maturity

given from 24-34 wks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q
Which indicate an optic nerve lesion?
	Excessive conjunctival edema
	Ptosis
	Inability to gaze laterally
	Afferent pupillary defect
A

Pupil size, controlled centrally by the Edinger-Westphal nucleus in the midbrain, is primarily based on the afferent light stimulus transmitted via the optic nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

18 year-old female c/inc. vaginal d/c + odor & urinary frequency.
PE = thin, gray, frothy vaginal d/c, red cervix, pH 6. Which of the following is the most likely diagnosis?
-Candida vaginitis
-Bacterial vaginosis
-Trichomonas vaginitis
-Chlamydia Trachomatis
-Gonorrhea

A

Tric = thin frothy or bubbly, pale yellow-green to gray adherent vaginal d/c, red vulva/vagina, petechiae on cervix, amine odor, dysuria/dyspareunia, pH 5 to 6.5 (basic).
• Candida = hypha (KOH) & cottage cheese
• BV = clue cells, Sniff test, Fishy odor
• Tric = Protozoa, strawberry cervix, thin frothy/bubbly, yellow-green-gray
• Chlamydia = clear d/c
• Gonorrhea = yellow prulent d/c

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q
A patient with a history of severe peptic ulcer disease is 5 weeks status post Billroth I surgery. One week ago he restarted his normal diet and has had the onset of severe nausea, abdominal cramping, and light-headedness that occur approximately thirty minutes after eating. The abdominal exam reveals a healing surgical scar without areas of unusual tenderness or any palpable masses. Which of the following is the most likely diagnosis?
	Anxiety disorder
	Celiac sprue
	Dumping syndrome
	Irritable bowel syndrome
A

Dumping syndrome typically occurs after Billroth type I surgeries as well as gastric bypass surgeries when the patient attempts to eat a large amount of simple sugars.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q
A 41 year-old female complains of 3 weeks of gradually worsening pain at the base of the thumb and radial aspect of the wrist. She and her husband have been renovating their home for the past 2 months and it has become increasingly difficult for her to hold a hammer. She denies numbness or tingling. She denies any history of previous trauma to the wrist. On examination, there is tenderness over the distal radial styloid and pain reproduced with ulnar deviation of a fist clenched over the abducted thumb. Which of the following is the most likely diagnosis?
	Carpal tunnel syndrome
	deQuervain's tenosynovitis
	Ganglion cyst
	Volar flexor tenosynovitis
A

deQuervain’s tenosynovitis typically results from repetitive activity involving pinching the thumb while moving the wrist. There is often pain and tenderness over the radial styloid and Finkelstein’s is positive in this patient.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

A 40 year-old female presents with a Pap smear abnormality revealing atypical glandular cells (AGUS). What is the most appropriate intervention?
HPV DNA testing
Colposcopy with endometrial curretage(ECC)
Repeat Pap smear in 3 months
Colposcopy and endometrial sampling

A

Colposcopy and endometrial sampling are important to perform in patients with AGUS Pap results because glandular cells are associated with squamous and glandular precursor lesions and carcinoma.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q
Which of the following is the most common presentation for an elderly female patient with primary hyperparathyroidism?
	Abdominal pain
	Renal lithiasis
	Acute pancreatitis
	Asymptomatic
A

primary hyper-parathyroidism = F >50 yo => incidental finding on routine labs => hypercalcemia

17
Q
A male patient presents for a routine physical examination. He denies chronic health problems, regular medication use or previous surgeries. He exercises 4-5 times weekly, does not use tobacco products, and consumes alcohol in moderation. His last intake of alcohol was two weeks ago while on a trip to Mexico. His review of systems and physical examination are both negative. Routine labs were drawn which were significant for the following: Total serum bilirubin 3.5 mg/dL (0.3-1.0 mg/dL), direct bilirubin 0.2 mg/dL (0.1-0.3 mg/dL), AST 35 U/L (0-35 U/L), ALT 30 U/L (0-35 U/L), Alkaline Phosphatase 48 U/L (30-120 U/L) and GGT 12 U/L (1-94 U/L). What is the most likely diagnosis in this patient?
	Alcoholic hepatitis
	Crigler-Najjar syndrome
	Gilbert's syndrome
	Wilson's disease
A

Gilbert’s syndrome is a relatively common cause of mild isolated elevations in indirect serum bilirubin.
• ETOHIC hep = ALT 3x ULN
• Crigler -Najjar syndrome
• Gilbert’s = incidental finding, inherited condition. Only causes cosmetic sxs (jaundice), does not req tx
• Wilsons = Cu overload  vital organs & brain

18
Q
long history of dyspepsia refractory to maximum appropriate therapy. A recent upper GI series revealed multiple gastric and duodenal ulcerations with prominent mucosal folds. What diagnostic study would be confirmatory of this patient's suspected diagnosis?
	EGD with duodenal biopsy
	Serum gastrin level
	Helicobacter pylori serology
	Abdominal CT scan
A

Serum gastrin levels can be elevated for many reasons; however significant elevations in a fasting state as well as with the secretin stimulation test are confirmatory for Zollinger-Ellison syndrome which is highly suspect in this case.