JOHN WESt Flashcards
FRC
functional residual capacity
Max inhalation
Total lung capacity
Max inhalation + Max exhalation
Vital capacity
Inhalation + exhalation
tidal volume
baseline of 0 + exhalation baseline
functional residual capacity
baseline of 0 + max exhalation baseline
residual volume
FRC by Helium dilution equation
C1 x V1 = C2 (V1+ FRC)
FRC by Plethysmograph
Box:
P1V1 = P2(V1 - delta V)
Lung:
P3 FRC = P4 (FRC + delta V)
Boyle’s law
Pressure x volume is a constant at constant temp
Lung disease can give a lower volume when using helium dilution.
Tidal vol x RR = Total vent
Dead space (150ml) x RR = Total dead space / min
Alveolar Vent = Total Vent - Total dead space
V (CO2) = alveolar vent x (%CO2/100)
P(CO2) = FCO2 x K
P(CO2) = part pressure
FCO2 = Fractionated co2
K = constant
Alveolar vent = (V(CO2) / P(CO2)) x K
alveolar Vent and PCO2 are inversely proportional
dbl alveolar vent = half PCO2
Half Alveolar vent = dbl PCO2
CSA increases as we get lower into the alveolar
ratio of ventilation to blood flow
1
concentration of dry air and partial pressure
FO2 = 0.21 (21%)
Baro Pressure = 760 mmHg
PO2 = 0.21 x 760
= 160 mmHg
Effect of water vapor and partial pressure
Baro Pressure 760 mmHg
37C = Ph2o = 47 mmHg
Pdry = 760 - 47 = 713mmHg
PO2 = 0.21 x 713
= 150 mmHg
If water vapor is 100C
Water vapor
PO2 = 760 mmHg
temp when water boils
partial pressure of air in water
150 mmHg
air O2 = 21ml/dl
water O2 = .45 ml/dl
solubility of o2 in h20
= 0.45 x 150 mmHg
= 0.003 ml/dl/mmHg
solubility = 0.003 ml/dl/mmHg
PO2 art = 100mmHg
0.003 x 100 mmHg
= 0.3ml/dl = 3ml/L (O2)
CO = 30L/min
Max O2 avail = 90ml/min
O2 req = 3000ml/min
HGB dissociation curve
Art Blood 100 PO2,mmHG / 100 O2 sat
Venous blood 40 PO2 mmHg / 75 O2 sat
P50 27 PO2 mmHg / 50 O2 sat
Total O2 concentration of arterial blood
1.39 ml/o2 / 1g hgb / %sat/100 + 0.003 x po2
ex
1.39 x 15 x .97 + 0.003 (100)
= 20.5 ml/dl
What shifts the O2 curve to the right?
increase in
CO2, H+, 2,3 DPG, Temp.
How much more affinity of O2 is CO (carbon monoxide)?
140x
What are the 3 forms of CO2 in the blood?
dissolved
bicarb
carbamino compounds
solubility of o2 in blood
solubility of CO2 in blood
0.003 ml/dl
0.067 ml/dl (24x more)