Jeopardy Substance slides

Question 1

Opioids can be detected thru a urine drug test for this many hours after administration of the opioid

Answer 1

What is 12-36 hours?

Question 2

This type of liver disease may occur
in up to 90% of persons who
inject opioids

Answer 2

What is hepatitis C?

Question 3

HIV, hepatitis, tuberculosis, and
this cardiac related condition
are serious medical problems
for IV opiate users

Answer 3

What is bacterial endocarditis?

Question 4

This physical sign of opiate withdrawal is also “seen” in hallucinogen intoxication and stimulant intoxication

Answer 4

What is pupil dilation?

Question 5

Opioid intoxication may be diagnosed by administering this opioid antagonist challenge

Answer 5

What is naloxone (narcan)?

Question 6

These two symptoms are associated with more severe opiate withdrawal and are often not seen in routine clinical practice

Answer 6

What is piloerection & fever?

Question 7

Suboxone is a combination of these two medications

Answer 7

What is naloxone (narcan) & buprenorphine?

Question 8

Yawning, insomnia, dizziness, diarrhea
This one is not part of opiate
withdrawal

Answer 8

What is lightneadedness?

Withdrawal: dysphoria, N/V, muscle aches, lacrimation/rhinorrhea, pupil dilation/piloerection, fever, sweating,

Question 9

Signs of opioid intoxication are pupil constriction, drowsiness/coma, impaired attention or memory,
and this

Answer 9

What is slurred speech?

Question 10

This can differentiate PCP intoxication & stimulant intoxication from each other

Answer 10

What is a urine drug test?

Clinical picture is similar though rotary nystagmus may be seen in PCP intoxication but not stimulant

Question 11

Cocaine users often use sedative substances–most often this substance–to reduce insomnia, nervousness, and other unpleasant side effects

Answer 11

What is alcohol?

Question 12

Amphetamine type stimulant users often use sedative substances–most often this substance–to reduce insomnia, nervousness, and other unpleasant side effects

Answer 12

What is marijuana?

Question 13

This sign is often present and is a reliable measure of stimulant withdrawal

Answer 13

What is a bradycardia?

Question 14

Bipolar disorder, schizophrenia, other substance use disorders, and this personality disorder in particular are risk factors for stimulant use disorder

Answer 14

What is antisocial personality disorder?

Question 15

This type of sample can be used to detect use of a stimulant up to
90 days after the use

Answer 15

What is a hair sample

Question 16

These two forms of cocaine administration have the most rapid onset of action

Answer 16

What is inhalation and injection?

Question 17

A speedball is the combination of cocaine and this drug

Answer 17

What is heroin?

Question 18

Cocaine increases the levels of glutamate and this neurotransmitter

Answer 18

What is dopamine?

Question 19

In terms of operant conditioning, the alcohol induced buzz/high is this; also tolerance results in the lack of this

Answer 19

What is positive reinforcement?

Question 20

In terms of operant conditioning, consuming alcohol to stave off alcohol withdrawal symptoms results in this

Answer 20

What is negative reinforcement

Question 21

Most substance induced disorders resolve within this amount of time after the cessation of acute withdrawal, the cessation of severe intoxication, or the use of the substance.

Answer 21

What is 1 month?

Most improve within days to weeks of abstinence

Question 22

The prevalence of alcohol use disorder in this sex is twice as much as the other

Answer 22

What is males?

Males ~12%, Females ~5%

Question 23

For an individual who has a close relative (parent) with an alcohol use disorder, their risk is this many times higher than normal

Answer 23

What are 3-4 times?

Question 24

Alcohol metabolizing enzyme genetic polymorphisms result in flushing, palpitations, & possibly more severe reactions in individuals of this race when they consume alcohol

Answer 24

What is Asians?

Japanese, Chinese, and Koreans are at lower risk for Alcohol Use Disorders

Question 25

Elevations in these two lab test results are sensitive indicators of ongoing heavy drinking and can be used to monitor abstinence

Answer 25

What is gamma-glutamyltransferase (GGT) and carbohydrate-deficient transferrin (CDT)?

Question 26

While elevation of GGT, CDT, and this test indicates a history of heavy drinking, GGT & CDT test may also be useful in detecting a relapse to heavy drinking, but this test is not

Answer 26

What is mean corpuscular volume (MCV)? | Not useful for monitoring due to long half life of RBC’s

Question 27

The patients with bipolar disorder, schizophrenia, & this personality disorder have a markedly high rate of co-morbid alcohol use disorder

Answer 27

What is Antisocial Personality Disorder?

Question 28

Substance use disorder pts, especially those with severe disorder, have an underlying change in this which persists even beyond detoxification

Answer 28

What is brain circuitry?

Question 29

Impaired control, Social impairment, Risky use, or Pharmacological criteria Continued use despite persistent or recurring interpersonal problems

Answer 29

What is social impairment?

Question 30

Impaired control, Social impairment, Risky use, or Pharmacological criteria A desire to cut down or unsuccessful attempts decrease or stop use refers to this Criterion A

Answer 30

What is impaired control?

Question 31

Impaired control, Social impairment, Risky use, or Pharmacological criteria Pharmacological criteria refers to “putting up” with these two phenomenon

Answer 31

What is tolerance & withdrawal?

Question 32

Impaired control, Social impairment, Risky use, or Pharmacological criteria Taking the substance in larger amounts or over a longer time period than intended refers to this Criterion A

Answer 32

What is impaired control?

Question 33

Impaired control, Social impairment, Risky use, or Pharmacological criteria Use in physically hazardous situations or continued use despite knowledge the substance is causing or worsening a medical problem is called this

Answer 33

What is risky use?

Question 34

Impaired control, Social impairment, Risky use, or Pharmacological criteria Spending a great deal of time obtaining, using, or recovering from the substance use refers to this Criterion A

Answer 34

What is impaired control?

Question 35

Impaired control, Social impairment, Risky use, or Pharmacological criteria Failure to fulfill major obligations at work, home, or school refers to this Criterion A

Answer 35

What is social impairment

Question 36

Impaired control, Social impairment, Risky use, or Pharmacological criteria Craving refers to this Criterion A

Answer 36

What is impaired control?

Question 37

Caffeine intoxication may induce a sleep disorder or this type of substance induced disorder

Answer 37

What is anxiety?

Question 38

Marijuana intoxication may induce anxiety disorders, sleep disorders, and this type of substance induced disorder

Answer 38

What is Psychotic disorder?

Question 39

The hallucinogen phencyclidine may induce psychotic disorders, anxiety disorders, delirium, & this type of substance induced disorders

Answer 39

What are mood disorders? | both bipolar & depressive

Question 40

Opioid intoxication may induce sleep disorders, sexual dysfunction, delirium, & this type of substance induced disorder

Answer 40

What is depressive disorders?

Question 41

Opioid intoxication will not, but opioid withdrawal may induce this type of substance disorder

Answer 41

What are anxiety?

Question 42

Alcohol & sedative/hypnotic intoxication may both induce the same type of substance disorders except sedative/hypnotic intoxication will NOT induce this

Answer 42

What is anxiety? | Psychotic, Bipolar, Depressive, Sleep, Sexual Dysfunction, Delirium, Neurocognitive disorders

Question 43

Intoxication & withdrawal of stimulants such as cocaine may induce, anxiety, OCD, sleep, & this type of substance induced disorder

Answer 43

What is mood? | both bipolar & depressive

Question 44

Inhalants and this type of substance do not cause a withdrawal

Answer 44

What is hallucinogens?

Question 45

Use of a single joint can lead to a positive urine marijuana test as many as this number of days later

Answer 45

What is 4 days?

Question 46

``` Use of marijuana at an early age may interact with those who have the genetic predisposition & promote the development of this serious mental illness ```

Answer 46

What is schizophrenia?

Question 47

The most common psychiatric adverse side effects of marijuana use is psychosis and this

Answer 47

What is anxiety/panic attacks?

Question 48

Cognitive effects of marijuana include amotivation, disorientation, unsteady coordination, altered perception, decreased consciousness and this reason for poor academic performance

Answer 48

What is memory loss?

Question 49

10, 20, 30, 40, 50 The percent of users who become dependent on marijuana is this

Answer 49

What is 10%?

Question 50

This synthetic Cannabinoid agonist is used to treat anorexia and weight loss in AIDS pts & nausea/vomiting in pts getting chemo

Answer 50

What is dronabinol (marinol)

Question 51

Marijuana’s clinical properties include: | anti-inflammatory effects anti-convulsant effects and anti- this effect

Answer 51

What is anti-emetic?

Question 52

Potentially life threatening; Significant discomfort; Mild symptoms; This most commonly describes withdrawal from marijuana

Answer 52

What is mild symptoms?

Question 53

Marijuana use that leads to a reduction in prosocial goal directed activities that may contribute to poor school or job performance is commonly called this

Answer 53

What are amotivational syndrome?

Question 54

This non-nicotine agent is thought to increase dopamine and norepinephrine levels and mimic some of the effects of nicotine

Answer 54

What is Bupropion (Wellbutrin)?

Question 55

This smoking cessation medication is a long acting partial agonist at the α4β2NAR

Answer 55

What is varenicline (chantix)?

Question 56

This tricyclic antidepressant is not first line but a second line smoking cessation agent due to its side effect profile

Answer 56

What is nortriptyline?

Question 57

It is unusual to rare for an individual to start smoking after this age

Answer 57

What is 21?

Question 58

Nicotine withdrawal from smoking cessation usually begins within 24 hours, and peaks at this time after cessation

Answer 58

What is day 2-3?

Question 59

Nicotine withdrawal from smoking cessation usually will last this long

Answer 59

What is 2-3 weeks?

Question 60

This alpha-2 adrenergic agonist is used for treating hypertension but has shown promise for smoking cessation

Answer 60

What is clonidine?

Question 61

The most common tobacco use product is this

Answer 61

What is cigarettes?

Question 62

Disappearance of nausea and dizziness despite repeated tobacco use is an indication of this

Answer 62

What is tolerance?

Question 63

For ♀ & older adults, a social or moderate drinker is one who does not binge drink & consumes no more than this number of drinks per day on average

Answer 63

What is one?

Question 64

These type of peptides mediate some of alcohol’s rewarding effects by enhancing the midbrain release of dopamine

Answer 64

What is opioid

Question 65

This medication inhibits aldehyde dehydrogenase leading to a build up of acetaldehyde and negative reinforcement of alcohol use

Answer 65

What is disulfiram (antabuse)?

Question 66

This medication that is used in the treatment of alcohol dependence is available in a monthly depot injection

Answer 66

What is naltrexone (vivitrol)?

Question 67

These two medications are contraindicated in pts with significantly compromised liver function

Answer 67

What are disulfiram (anatbuse) and naltrexone (vivitrol)?

Question 68

This medication helps prevent relapse, has a common side effect of diarrhea, is safe in hepatic compromised pts, but is contraindicated in pts with severe renal disease

Answer 68

What is acamprosate (campral)

Question 69

Naltrexone is most effective in treating this aspect of alcohol dependence

Answer 69

What are cravings?

Question 70

Standard drug screens do not detect these drugs and usage typically declines dramatically after the teen years

Answer 70

What is inhalants?

Question 71

``` The phenylalkylamines class of hallucinogens includes mescaline, DOM, and this most well known drug ```

Answer 71

What is MDMA (ecstasy, XTC)?

Question 72

First developed as a anesthetic, this drug produces feelings of separation from mind and body-dissociation

Answer 72

What is Phencylcidine (PCP)?

Question 73

MDMA, LSD, or PCP: | Continued use of this hallucinogen has been linked to neurotoxic effects

Answer 73

What is MDMA (ecstacy)?

Question 74

Any inhaled volatile hydrocarbons (glues, fuels, paints) may produce “sudden sniffing death” due to this

Answer 74

What is cardiac arrhythmia?

Question 75

Phencylclidine (PCP) can be detected in the urine up to this many days after use

Answer 75

What is 8?

Question 76

The ergoline class of hallucinogens includes this drug which often produces visual hallucinations which can be frightening to the use

Answer 76

What is lysergic acid diethylamide (LSD)?

Question 77

While lab testing can detect PCP, may or may not be helpful detecting hallucinogens, lab testing is not helpful detecting this

Answer 77

What are inhalants?

Question 78

Intoxication with this drug may produce vertical or horizontal nystagmus, diminished responsiveness to pain, and violent behavior

Answer 78

What is Phencyclidine (PCP)?

Question 79

The proportion of users of this are most likely to become dependent on the substance

Answer 79

What is nicotine?

Question 80

Use of this illicit drug is most commonly involved in ER visits

Answer 80

What is cocaine?

Question 81

When sober, users of this drug(s) may re-experience geometric visual hallucinations, flashes of color, intensified colors, or misperception of objects being too large or too small

Answer 81

What are hallucinogens? | Primarily LSD

Question 82

About 50% of people who attempt to quit smoking develop withdrawal and commonly complain of irritability, difficulty concentrating, and this

Answer 82

What is anxiety?

Question 83

Over 80% of tobacco users attempt to quit, 60% relapse within 1 week, and this number succeed and do not ever relapse

Answer 83

What are 1 in 20 (5%)?

Question 84

A drink is defined as a 1 ounce shot, this 4-6 ounces of wine, or this many ounces of beer

Answer 84

What are 12?

Question 85

Psychostimulants specifically worsen this symptom of schizophrenia

Answer 85

What are hallucinations? | And paranoia

Question 86

Use of marijuana, alcohol, or this before age 15 are considered to be the three “Gateway Drugs” to later dependence problems

Answer 86

What is nicotine?

Question 87

The most common illicit drug used worldwide across all age | groups is this

Answer 87

What is marijuana?