Jen Cards Quiz 4

Question 1

Name 4 viruses that can cross the placenta.

Answer 1

Parvo B19, Rubella, VZV, CMV

Question 2

When would I use acyclovir vs. gancyclovir?

Answer 2

Acyclovir: for HSV 1 and 2, severe VZV. Gancyclovir: for CMV.

Question 3

Which viruses are transmitted via respiration?

Answer 3

Mumps, Measles, Rubella, VZV, Parvo B-19

Question 4

Disease with the shortest incubation for this quiz?

Answer 4

Arboviruses (7d in humans)

Question 5

Disease with the longest incubation for this quiz?

Answer 5

Prion disease?

Question 6

Viruses for which we have killed vaccines

Answer 6

HPV

Question 7

Diseases for which we have drug treatment?

Answer 7

HSV: acyclovir. CMV: gancyclovir.

Question 8

Which herpes disease is respiratorily transmitted?

Answer 8

VZV

Question 9

How would you diagnose EB?

Answer 9

positive heterophile test (antigenic cross-reactivity of Abs to EBV and sheep RBCs), AB does not neutralize EBV. Blood contains abnormal lymphocytes (cytotoxic T-lymphocytes produced in high numbers to attack the circulating B-lymphocytes that are infected with EB virus).

Question 10

DNA tumor viruses: how act?

Answer 10

p53 and Rb are common targets. Point is that they inactivate tumor suppressors.

Question 11

RNA tumor viruses: how act?

Answer 11

RNA tumor viruses tend to upregulate proto-oncogenes.

Question 12

Mech for DNA tumor virus to cause cancer?

Answer 12

Ubiquitinate p53, cause it to be degraded. May occur via E6.

Question 13

Vaccine for HPV?

Answer 13

Yes, Gardisil. 3 doses. Virus light particles, not full virus.