Jaundice clinical lecture

Question 1

What are liver damage patterns according to LFTs?

Answer 1

Hepatic/hepatocellular - ALT/AST elevated, alk phos/gGT near normal

Cholestatic - ALT/AST normal, alk phos/gGT elevated

Mixed - both elevated

Question 2

ERCP complications

Answer 2

Perforation, bleeding, infection, pancreatitis

Question 3

Define chronic liver disease

Answer 3

Duration greater than 6 months
Can present acutely, duration may be sub-clinical, outcome is progression to cirrhosis, signs and symptoms dependent on underlying disease or features of cirrhosis
pathology - recurrent inflamm and repair with fibrosis and regeneration

Question 4

What are common causes of cirrhosis?

Answer 4

Alcohol, HCV (Hep C), NASH (NAFLD)