Japanese encephalitis

Question 1

Vaccine - what vaccines are available

Answer 1

Give vaccine at least 1 week before travel

1) Imojev - LIVE ATTENUATED:
SINGLE dose - adults can consider having booster in 5 years (but not necessary)

2 doses 1-2 years apart for 9 mo - 18yo
NOT for <9 months old, pregnant/breastfeeding, immunocompromised, contraindication for LIVE vaccine

2) JEspect - ATTENUATED
TWO doses 28 days apart
(can have 2 doses 7 days apart)
Booster dose 1 year later
(Booster gives protection for 2 years)

Can be given from 2 months old
<3yo - give half dose - 0.25mL
Acceptable for pregnancy/breastfeeding

Question 2

JE prevention

Answer 2

Avoid being outdoors during NIGHT (dusk to dawn)

Advise vaccination for those spending >1 month in endemic areas

If

Question 3

JE transmission

Answer 3

Flavivirus transmitted via vector Culex mosquitoes

Humans are incidental/dead-end hosts, i.e no human-human or human-mosquito transmission

Question 4

Incubation period

Symptoms

Treatment

Answer 4

-Incubation: 5-15 days from infection to symptoms of illness

-Symptoms:
Headache, fever, vomiting
Mental status changes, neurologic symptoms, weakness, and movement disorders might develop over the next few days.
Seizures common in children

If develop encephalitis, 20-30% mortality

• Treatment:
  Supportive