IV Nerve Palsy - Trochlear Flashcards

1
Q

Describe a IVth nerve palsy - which muscle is affected?

A
  • IV CN Palsy causes a palsy of SO muscle
    o 4th CN only supplies ONE MUSCLE
  • Purely a motor muscle
  • Unilateral/bilateral
    o More commonly bilateral
  • Congenital/acquired
    o Can sometimes be congenital but not found until later teen or early adulthood
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2
Q

What are the features of a IVth nerve palsy?

A
  • Loss of depression  so affected eye is sitting higher
    o Deviation is a hyper deviation that may or may not be controlled – more eso than exo
  • Loss of incyclotorsion
  • Loss of relative abduction
    SO works at near – if issue with SO – will have bigger vertical & bigger ESO at near than at distance
    Convergence should be completely fine
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3
Q

Describe the anatomy of the IVth nerve?

A
  • Dorsal midbrain at level of inferior colliculus ventral to cerebral aqueduct
  • Decussation – R nucleus becomes L nerve, L nucleus becomes R nerve
  • Moves posterior
  • Fibres cross over
  • Leaves midbrain
  • Sweeps round midbrain
  • Runs between posterior cerebral artery & superior cerebellar artery
  • Enters cavernous sinus below IIIrd & ophthalmic division of Vth
  • Enters Superior Orbital Fissure above annulus of Zinn
  • Innervates SO
  • SO is a complex muscle – lots can happen to it
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4
Q

What is the aetiology of acquired IVth nerve palsy?

A
  • Closed head trauma accounts for most acquired bilateral palsies & many unilateral
    o Due to anatomy  bashing head off floor, decelerating injury e.g. traffic accident (whiplash)
    o In a child, trauma would be quite common
     If have teenager w/ 4th nerve palsy – will not know if congenital or through childhood trauma
     If adult develops it with no trauma  then could be a vascular reason
  • Microvascular – hypertension, DM, high cholesterol
  • Midbrain stroke
  • Intracranial tumours – not common cause of 4th palsy (so not really looking for these pxs to be scanned unless other things ruled out)
  • Myasthenia Gravis – can mimic anything – if px has this they will have other signs & symptoms too (ALWAYS WRITE THIS IN THE EXAM!!)
    Think off aetiology in age groups – what could apply to this px?
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5
Q

What is the aetiology of congenital IVth nerve palsy?

A
  • 38.3% unilateral – 10% bilateral
  • Anatomical anomaly of SO tendon, complete absence, abnormal insertion or excessively lax tendon
    o If due to lax tendon then needs different management
  • Autosomal dominant form of inherited congenital SO palsy
    o Can be familial
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6
Q

Describe a congenital unilateral IVth nerve palsy?

A
  • Px usually presents w/ an AHP (abnormal head position) in childhood but that can also be detected quite late in life
    o AHP needs investigated, look at old photos
  • All children w/ an AHP should have a full orthoptic/ophthalmological examination to rule out an ocular cause
  • AHP in unilateral form:
    o Will tilt to unaffected side
    o Vertical deviation: e.g R>L –> will always tilt to lower eye
    o Head tilt to left – probably have a R 4th nerve palsy
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7
Q

Describe a congenital bilateral IVth nerve palsy?

A
  • Usually a V-pattern Esotropia with hyperdeviation of non-fixing eye
  • Chin depression
  • +ve BHTT on either side confirms a bilateral palsy
    o Reversal of hypertropia on R & L tilt
  • No torsional symptoms but obvious torsion on fundoscopy
    o No torsional symptoms since brain suppresses it
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8
Q

Describe Abnormal Head Posture and facial asymmetry?

A
  • Head tilt unaffected side
  • Head turn to unaffected side
  • Chin depression
  • If acquired AHP then will have vertical diplopia
  • Longstanding problems will have a compensatory head posture & new problems will not
    Facial asymmetry – head tilt, chin depression – head tilt/head posture is what is allowing child to see clearly (not have diplopia)
  • Facial asymmetry is common in congenital palsies – it develops secondary to torticollis (shortening of neck) – facial asymmetry due to parts of face growing at different rates
  • Reduction in distance between lateral canthus & corner of mouth on side of head posture
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9
Q

What is intermittent diplopia? Where will the deviation in a IVth nerve palsy be larger? How will you see excylcotorsion deviation?

A
  • Intermittent diplopia (at times can fuse, at other times cannot) can be 1st sign of decompensation as child ages – huge ability to have vertical fusion
  • Large hyperphoria w/ AHP & larger hypertropia w/o AHP
  • Deviation will usually be greater at near
  • Horizontal deviation of 8Δ occurs in 10% of cases  will be based on what they had before – more common is ESOphoria but if they already had an EXOphoria then they will still have this
  • Excyclodeviation can be seen on fundoscopy – will see the discs is tilted in comparison to macula – will barely see this deviation on cover test
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10
Q

Compare normal vertical fusion to IVth nerve palsy vertical fusion?

A

A normal px will have 3 dioptres of vertical fusion
Pxs w/ a longstanding or congenital 4th nerve palsy will often have increased vertical fusion (much more than 3 degrees)
Longstanding – could get this nerve palsy at 10 years old then have had it whole life

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11
Q

Describe the Bielschowsky Head Tilt Test (BHHT) in IVth Nerve Palsy?

A
  • Performed at 3 metres
    o This is to not isolate any muscles – if at 6m then favouring distance, if do it a lot closer then favouring near
  • Target: kay picture or letter on logMAR chart
  • Want know which direction the deviation is biggest in
  • Head is tilted 30° to affected side & if hypertropia increases then a SO palsy is present
    o If head tilted to affected side – eye shoots up – deviation gets bigger (SR now acting unopposed (do not have SO to keep eyes level)
  • Head tilt to unaffected side should show v little difference in deviation suggesting a contralateral SR under action
  • +ve result should be minimum 5Δ difference from tilting right to left
    o For it to be a +ve result then would have to measure with prism bars
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12
Q

Describe Parks 3 Step Test?

A
  • Cover test performed in primary position
  • Alternate cover test performed on dextroversion (BEs to R) & laevoversion (BEs to L) to assess the greater vertical deviation – looking left & looking right to see if there is a vertical deviation
  • BHHT is then performed tilting 30° right & left & noting the increase in hyperdeviation
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13
Q

Describe acquired IVth nerve palsy?

A
  • Recent onset of vertical diplopia
  • No evidence of enlarged vertical fusion ranges
  • Subjective awareness of AHP – px will know it
  • BHHT will be +ve if px tilts to affected side
  • History of trauma (most common aetiological factor)
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14
Q

Describe unilateral IVth nerve palsy?

A
  • Torsion is rarely complained of in unilateral palsies
  • Examination is as before w/ a positive BHHT
  • Hypertropia
  • Excyclophoria/tropia
    Can fuse ~3 degrees of excyclotorsion/incyclotorsion
    Pxs do not know how to complain about torsion – often cannot tell if things are tilted or not
    Cannot correct torsion optically – these pxs need surgery – REFER THE PX
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15
Q

Describe a bilateral IVth nerve palsy?

A
  • Torsional diplopia is main symptom – this prevents fusion
  • Excyclodeviation may exceed 10° in PP
  • Marked chin depression may be seen
    o More likely to be ESO looking down
  • Reversal of hypertropia on R & L gaze – w/ a +ve BHHT
  • V Eso pattern
    o The more eso further down you get them to look because SO has no function on abduction anymore
  • Bilateral palsy biggest issue is the torsion
    o Torsion cannot be relieved by prism – occlude one eye (to allow px to have comfortable viewing) – then consider surgery
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16
Q

What are the investigations into IVth nerve palsy?

A
  • As w/ all neurogenic palsies
  • Detailed history – microvascular causes (DM, hypertensive), ask about viruses (could be COVID - more likely causes a 6th palsy but could cause a 4th palsy), enquire about trauma
  • Hx of significant trauma – skull# (skull trauma), loss of consciousness, subdural haematoma
  • Full blood count, blood sugar levels, serum lipids
17
Q

What is the key presenting sign in a IVth nerve palsy?

A

Vertical problem and a head tilt then think 4th

18
Q

Describe the orthoptic investigation into a IVth nerve palsy?

A
  • VA N+D – always in log MAR
  • CT N+D w/ & w/o AHP
    o Looking to see if AHP helps them – does deviation get bigger??
  • OM – record diagrammatically
  • BHHT
  • PCT N+D+9 positions of gaze
    o Measure of angle of deviation (prism cover test)
  • Less/Hess
  • Bagolini Glasses (striated lenses)
    o Measuring sensory fusion – checking how they fuse
    o If binocular vision then they’ll see 1 light
    o If suppressing – will see 1 line
  • PFR – horizontal & vertical
    o Prism Fusion Range
    o Concerned if this is increased in Incomitant
    o Normal is 3 dioptres
  • Stereoacuity – TNO/Frisby
19
Q

State Hering’s Law and Sherrington’s Law?

A

Hering’s Law: Law of equal innervation
* When an impulse goes to muscle, causing it to contract, a simultaneous & equal impulse goes to its contralateral synergist to contract by an equal amount
Sherrington’s Law: Law of reciprocal innervation
* When increased innervation is sent to a muscle to cause it to contract – decreased innervation goes to its direct antagonist which is therefore relaxed

20
Q

What is the pattern of muscles affected in IVth nerve palsy and how does this help you determine onset?

A
  • Overaction of contralateral synergists according to Hering’s Law of equal innervation: IMMEDIATE
    o Know it’s happened within a week
  • Overaction of ipsilateral antagonist according to Sherrington’s Law of reciprocal innervation: TIME
    o week or 2 to a few weeks
  • Secondary inhibition of contralateral antagonist w/ Hering’s Law – this happens because overaction of antagonist in affected eye requires less innervation: MORE TIME
21
Q

What is the muscle sequelae of a IVth nerve palsy?

A
  • Underaction of ipsilateral SO
  • Overaction of contralateral IR
  • Overaction of ipsilateral IO
  • Inhibitional palsy of contralateral SR
    If not all steps of muscle sequelae occurred then know it is recent onset
22
Q

What are the four steps of muscle sequelae?

A
  1. Underaction of ipsilateral agonist (muscle affected)
  2. Overaction of contralateral synergist
  3. Overaction of ipsilateral antagonist
  4. Inhibitional palsy (underaction) of contralateral antagonist
23
Q

What is the difference between SR palsy and SO palsy?

A

SR palsy - ptosis & bigger in distance
SO palsy - no ptosis & bigger at near

24
Q

What are the investigations into a longstanding IVth with sequelae?

A
  • Relative concomitance from muscle sequelae – field look similar
  • Investigations: Cover test, Ocular motility, prism cover test (D&N – to prove which distance it is bigger in), measure palpebral aperture to assess for proptosis
25
Q

Describe how to investigate torsion?

A
  • Can be measures subjectively or objectively
  • Double Maddox rod (cylinders vertical so px has lines horizontal, red/green, give px diplopia w/ prism, get the px to turn trial frame axis until lines appear straight  10° if bilateral, 5° if unilateral – degrees of movement from 0 on trial frame) , Synoptophere, Torsionometer, Dulley Adaptation on Lees Screen
  • Synoptophore allows you to measure deviation & torsion together in 9 positions of gaze
  • Cyclodeviation is worse on depression & a barrier to fusion
26
Q

How much torsion do unilateral palsies produce vs bilateral palsies?

A
  • Unilateral palsies may produce 5/6 degrees of excyclotorsion which can be fused
  • Bilateral palsies typically produce excyclotorsion of 15 degrees & this cannot be fused
27
Q

What is the biggest problem in bilateral IVth? Will a child have a AHP?

A
  • Torsion is biggest problem in bilateral 4th nerve palsy
  • Bilateral 4th nerve palsy often asymmetrical
  • 4th nerve palsy & superior division 3rd nerve palsy present v similarly
  • Children who develop squints & have suppression then they have no reason to develop an AHP
28
Q

Comparing unilateral vs bilateral IVth nerve palsy - describe AHP, BHHT, Hypertropia, Excyclotropia and V Pattern - ?

A

UNILATERAL:
AHP: contralateral head tilt (face turn, chin depression)
BHHT: +ve (on one side)
Hypertropia: no reversal on versions & >5Δ (bigger, no swap)
Excyclotropia: not symptomatic & less than 10 degrees
V Pattern: uncommon

BILATERAL:
AHP: chin depression
BHHT: +ve (on both sides)
Hypertropia: reversal no versions and <5Δ (swaps from R to L)
Excyclotropia: symptomatic & greater than 10 degrees in acquired palsies
V Pattern: common

29
Q

Comparing congenital vs acquired IVth nerve palsy - describe Facial Asymmetry, AHP, Cyclotropia, Vertical Fusion

A

CONGENITAL:
Facial Asymmetry: common (more than normal)
AHP: present in photographs
Cyclotropia: not a symptom - no torsion (suppression)
Vertical Fusion: increased

ACQUIRED:
AHP: aware of holding head in an awkward position
Cyclotropia: symptomatic
Vertical Fusion: normal (3Δ - px cannot cope & get diplopia all time)