IV Induction Agent Dose, Onset, Duration

Question 1

Propofol (Diprivan)

Answer 1

Dose: 1 - 2.5 mg/ kg (2 mg/ kg), 25 - 75 mcg/kg/min (MAC), 100 - 200 mcg/kg/min (GA maintenance)
Onset: 30 seconds (to unconsciousness)
Duration: 5 - 10 minutes

Concentration: 10 mg/ mL

Question 2

Etomidate (Amidate)

Answer 2

Dose: 0.2 - 0.3 mg/ kg
Onset: Rapid
Duration: Short

Concentgration: 2 mg/ mL

Question 3

Ketamine (Ketalar)

Answer 3

Dose: 0.5 - 2 mg/ kg IV, 4 - 5 mg/ kg IM
Onset: 30 - 60 seconds
Duration: 10 - 20 minutes

Question 4

Dexmedetomidine (Precedex)

Answer 4

Dose: 0.5 - 1 mcg/ kg (given over 10 minutes), followed by infusion of 0.2 - 0.7 mcg/kg/hr
Onset: Initial distribution ~ 6 minutes
Duration: Infusion dependent

Question 5

Midazolam (Versed)

Answer 5

Dose: 1 - 2 mg in preop, 0.5 mg/ kg orally (in peds)
Onset: 2 - 3 minutes (peak effect for IV)
Duration: ~ 15 - 20 minutes

Question 6

Flumazenil (Romazicon)

Answer 6

Dose: 0.2 mg IV (over 15 seconds)
Onset: ~45 seconds

Can repeat dose at 1 minute intervals (not to exceed 4 doses)

Question 7

Thipental

Answer 7

Dose: 2.5 - 5 mg/ kg
Duration: long (elimination 1/2 life of 12 hours)

Question 8

Methohexital (Brevital)

Answer 8

Dose: 1 - 2 mg/ kg IV, 20 - 30 mg/ kg rectal
Duration: Shorter than thiopental (elimination 1/2 life of 4 hours)

Agent of choice for ECT procedures