IV Fluids Flashcards

1
Q

Definition of crystalloid

A

Small molecules that dissociate into ions and form true solutions

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2
Q

Number of moles of calcium in calcium chloride and gluconate

A

Chloride - 0.68mmol/ml
Gluconate 0.22mmol/ml

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3
Q

Potential Effect of calcium gluconate on cardiac function

A

Can be negatively inotropic and cause coronary vasospasm

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4
Q

Why is bicarb expensive

A

Usually fluids steralised by heat
If this is done to bicarb produces co2 thus lost
Thus bicarb must be filtered. Expensive

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5
Q

Osmolality of 0.9%nacl
Osmolality of na bicarb 8.4%

A

Nacl 300
Na bicarb 2000 (!)

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6
Q

How many mmol of na in 1L Na bicarb

A

1000

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7
Q

Which of colloids or crystalioids has the most impact on the freezing and boiling points of their solute

A

Crystalloids as lower number of molecules in colloids

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8
Q

Why do colloids also have electrolytes in them

A

Little osmotic pressure (all oncotic from the large molecules) so needs electrolytes to achieve is osmolality

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9
Q

mmol/l of na in has 4.5 and 20%

A

100-160
50-120

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10
Q

Ph of HAS

A

6.4 to 7.4

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11
Q

Ph of 0.9% nacl
Dextrose

A

5
4

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12
Q

Instance of serious adverse reactions to human albumin, gelofusin and dextran 70

A

Has 1:30,000
Gelofusin 1:13,000
Dextran 70 1:4500

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13
Q

How are gelatins made
Example
Molecular weight of gelatin

A

Hydrolysing collagen
Gelofusin
30000 daltons

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14
Q

Mmol of calcium in gelofusin and hartmanns

A

Gels 0.4 mmol/l
Hartmanns 2mmol/l

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15
Q

Constituents of dextran 70
Molecular weight

A

Dextrans (glucose polymers) in sodium chloride
Ave 70000 daltons

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16
Q

Composition of hydroxyethyl starches
Molecular weights

A

90% amylopectin that is etherified
Polysaccharide with starches and glucose with hydroxyethyl groups
Huge range but up to 450,000!

17
Q

Other than anaphylaxis issues with hydroxyethyl starches

A

Interfere with coagulation
Can persist outside of vascular compartment
Renal impairment

18
Q

How is human albumin solution produced
Clinical implication

A

Fractionation of plasma
Heat sterilised so infection risk very low
20% has made by removal of water and dissolved salts

19
Q

Weight of albumin in 1L of 4.5% and 20%

A

4.5% 40-50g
20% 150-250g

20
Q

What % of protien in has is albumin

A

> 95%

21
Q

Potential advantages of albumin (unproven)

A

Colloid properties
Molecular carriage
Coagulation
Membrane Integrity
Free radicle scavenger

22
Q

Advantages of stroma free haemoglobin

A

Good o2 carrier
Enters smallest capillaries
No need to cross match
Minimal infection risk
Easy to store and transport
Long shelf life

23
Q

Disadvantages of stroma free hb

A

Low p50 (oxygen tension at which hb is 50% saturated) - high affinity
Poor persistence
Nephrotoxicity
Immunological effect
Free radicle production
Increased nitric oxide scavenging

24
Q

p50 of intracellular (in RBC) and free Hb
Why

A

Intracellular 3.6kpa
Free 1.6kpa
Lack of 23dpg so much higher affinity

25
Q

Why doesn’t stroma free hb persits

A

Very quickly dissociates to monomers and diners which have molecular weights well below renal threshold of 69000 so excreted in urine

26
Q

What is the source of risk of nephrotoxicity for stroma free hb

A

Formed by red cell lysis so needs to be well washed

27
Q

How can the low p50 of stroma free hb be addressed

A

Microencapsulated hb
Put hb in mesh bag with DPG! Essentially an artificial cell

28
Q

How can oxygen be artificially carried (ie no Hb)

A

Chelating agents based on porphyrin
Perflorocarbons - fluoridated carbon skeleton - can absorb and carry oxygen. Still needs hyperbaric oxygenation to be successful