IUPA REV Flashcards
How does a fetal skull differ from an adults?
Large calvaria relative to face
No teeth
No mastoid or styloid process
Small nasal cavities
What form the borders between the cranial fossa?
Lesser wing sphenoid
Superior border petrous part of temporal bone
What are fontanelles?
Areas of unossified membranous gaps between flat bones of calvaria
When do the fontanelles close?
Anterior - 18 months to 2 years
Posterior - 1-3 months
Where is the bleeding in a cephalohaematoma, is the brain compressed?
between periosteum and bone.
No brain compression - outside skull.
Which vessels lie in the dense connective tissue layer of the scalp?
Vessels supplying scalp
Supraorbital + supratrochlear
Occipital, pre-auricular and superficial temporal
Which vessels lie in the loose connectivity tissue layer of scalp?
Emissery veins - connect vessels in dense ct layer with dural venous sinus.
How can scalp infections spread intracranially?
Emissery veins connecting vessels in deep ct layer to intracranial venous sinuses.
What space do bridging veins traverse?
Subdural space - drain cerebral veins in subarachnoid space into dural venous sinus
What does the MMA supply?
Bones of skull + dura
Where is the bleeding in an extradural haemorrhage?
Between skull and periosteal layer dura
Where is the bleeding in a subdural haemorrhage?
Subdural space - between dura and arachnoid mater
Which type of intracranial haemorrhage can be confirmed by lumbar puncture?
Subarachnoid -blood mix with CSF in subarachnoid space
Which artery has an important relationship with recurrent laryngeal nerve?
Inferior thyroid artery - from thyrocervical trunk
Which bone is the cavernous sinus in?
Sphenoid bone
What are 2 complications of infections spread intracranially from the face?
Cavernous sinus thrombosis
Meningitis
What is the significance of the ‘danger triangle’ of the face?
Infections in this region can spread through venous system to dural venous sinuses and intracranially. Pterygoid plexus (extracranial) via valveless emissary veins to cavernous sinus (intracranial).
Which skull hole does IJV pass through?
Jugular foramen
Branches from which arteries supply the nasal septum?
Ophthalmic - ant and post ethmoidal
Maxillary - sphenopalatine and greater palatine
Facial - superior labial
Which side is the thoracic duct? where does it drain into?
Left side
Subclavian vein
Which nodes may be enlarged in conjunctivitis, tonsillitis and mouth ulcer?
Pre-auricular
Jugulo-digastric (deep)
Submental
Where is the olfactory cortex?
Temporal lobe- uncus
What are 3 signs of CNIII nerve palsy?
Ptosis
Dilated pupil
Down and out position
Why does horners syndrome only cause partial ptosis?
LPS still functioning - supplied by CNIII
Sympathetics supplying superior tarsal affected.
Which cranial nerve emerges from the dorsal aspect of brainstem?
Trochlear
Which 2 cranial nerves emerge from midbrain?
CNIII - oculomotor
CNIV - trochlear
Which 4 cranial nerves emerge from pons?
V- trigeminal
VI- abducens
VII - facial
VIII - vestibulocochlear
Which cranial nerve is vulnerable if raised ICP, why?
Abducens - emerges at pontomedullary junction and courses close to bone into cavernous sinus.
What reflex tests the facial nerve?
Corneal reflex - orbicularis oculi
Which component of CNVIII do acoustic neuromas arise from?
Schwann cells of vestibular nerve
What are the symptoms of an acoustic neuroma?
Unilateral hearing loss Tinnitus Vertigo Numbness Weakness in half of face - compress facial n.
Which nerves pass through the jugular foramen?
Glossopharyngeal
Vagus
Spinal accessory
Explain 3 signs of horner’s syndrome.
Partial ptosis - superior tarsal muscle
Miosis - dilator pupillae
Anhydrosis - no sweat gland stimulation
Which structures are formed from the pouches of pharyngeal arches?
Eustacian tube and middle ear cavity
Palatine tonsils
Thymus and parathyroid glands
What is ramsey-hunt syndrome?
Reactivation of varicella zoster virus from geniculate nucleus
What ear pathology causes painless, smelly otorrhea?
Cholesteatoma
What are 4 causes of sensorineural hearing loss?
Acoustic neuroma
Meniere’s disease
Presbyacusis
Ototoxic medication
What are 4 causes of conductive hearing loss?
Wax
Otitis media
Glue ear
Otosclerosis
Where are the anterior chamber and posterior chamber of eye?
Anterior - between iris and cornea
Posterior - between iris and lens
How might closed-angle glaucoma present?
Sudden onset of painful red eye
Irregular oval-shaped pupil
Nausea and vomiting
Eye hard and tender to palpate through eyelid
What is the main refractor of the eye?
Cornea
What complication can arise from ethmoid sinusitis?
Orbital cellulitis
Head and neck cancers are usually ___________.
squamous cell carcinoma
What investigation can be done if thyroid cancer suspected?
FNAC - fine needle aspiration for cytology
What is the most common type of thyroid cancer?
Papillary - adenocarcinoma
Give 4 differentials for scrotal swelling.
Testicular torsion
Hydrocele
Testicular cancer
Scrotal hernia
What does the cremasteric reflex test?
Genitofemoral nerve - L1
Where is the most common site of ectopic pregnancy?
Ampulla
What is the lymph drainage of the fundus of uterus?
Para-aortic
What is the lymph drainage of the body of the uterus?
Upper - external iliac
Lower - internal iliac
What is the lymph drainage of the cervix?
Internal iliac
Sacral
What is the lymph drainage of the thirds of the vagina?
External iliac
Internal iliac
Superficial inguinal
Give an example of a condition which causes hypergonadophic hypogonadism.
Turners syndrome - 45 XO = primary ovarian failure
What are GnRH agonists used to treat?
Endometriosis
Uterine fibroids
What do theca cells secrete?
Androgens -> Oestrogens
What do granulosa cells secrete?
Oestrogen
What happens during LH surge?
Granulosa cells become sensitive to LH and secretes progesterone
At which stage is the endometrium at max thickness?
Early secretory
Variations in menstrual cycle are due to which phase?
Follicular phase
Luteal phase strictly 14 days +-2
What effects do oestrogen and progesterone have on the myometrium?
Oestrogen - thickens and increases motility
Prog - thickens and decreases motility
How is secondary amenorrhoea defined?
No menstrual period for 6 months
What are causes of primary amenorrhoea?
Structural - agenesis, imperforate hymen
Chromosomal - Turner’s
Hormonal - HPA axis
What are causes of secondary amenorrhoea?
Pregnancy
Weight loss
Stress
PCOS - raised LH:FSH ratio
What is the MOA of sildenafil?
Inhibits phosphodiesterase, increased cGMP, increased NO.
What are 4 causes of erectile dysfunction?
Drugs - anti-depressants
Vascular - atheroma
Tears in tunica albuginea
Psychological inhibition
How does high dose progesterone act as contraception?
Inhibits positive feedback of oestrogen - No LH surge, inhibiting ovulation.
What are possible SE of taking COCP?
MI, stroke, thromboembolism
Increased risk of breast cancer + cervical cancer (no STI protection)
What is the commonest female cause of infertility?
Anovulation
What is the commonest cause of irregular, upper tract bleeding in females?
Anovulation
Which intrauterine device is used for patients with heavy bleeding?
IUS - progesterone secreting
What is the primary and secondary action of IUD?
Primary - Cu toxic to sperm and ovary
Secondary - endometrial inflammatory reaction inhibits implantation, thickens cervical mucus.
What are the disadvantages for intrauterine contraception?
No STI protection
Insertion unpleasant
Risk of uterine perforation
Displacement/expulsion possible
Which oral contraception has a risk of ectopic pregnancy?
Low dose progesterone (POP) - doesn’t inhibit ovulation.
What is the decidua?
Thickened endometrium
What are 2 examples of implantation defects?
Ectopic - ampulla
Placenta praevia - lower uterine segment blocking cervix, haemorrhage risk.
Where would you inject an epidural?
L4/5
What is used to assess fetal head position in birth canal?
Anterior fontanelle
What happens to vaginal pH after menopause?
increases - less glycogen, less lactic acid produced lactobacilli.
What are risk factors for prolapse?
Age Vaginal delivery Post-menopause Obesity - raised pressure Ct disorders
How is chlamydia trachomitis diagnosed?
Men - first catch urine
Women - vaginal swab
How is neisseria gonorrhoea diagnosed?
Swab and gram stain - gram -ve diplococcus (pink)
Which STI is protozoa?
Trichomonas vaginalis
How are genital ulcers treated?
Aciclovir - herpes simplex
What is the commonest cause of ectopic pregnancy?
Previous salpingitis - scarring of tube epithelium.
What is PID?
Infection of upper reproductive tract - travelled through cervix into uterus.
What is the treatment for PID?
Antibiotics for 14 days
Other than gonorrhoea and chlamydia, what can cause PID?
IUD - copper coil
How does PID present?
Fever
Lower abdominal pain and tenderness
Pain during intercourse
Vaginal discharge
What are 3 complications of PID?
Ectopic pregnancy - cilia damage
Infertility
Fitz- hugh- curtis syndrome - per-hepatitis after chlamydial PID.
What are risk factors for endometrial carcinoma?
Overweight - adipose tissue secrete oestrogen
Anovulation
Exogenous - HRT
Post-menopause
COCP is protective against which cancer?
Ovarian epithelial
What are risk factors for ovarian epithelial cancers?
Nulliparity or low parity
Heritable mutations - BRCA1/2
Smoking