IT 1 (MedChem)

Question 1

2-phenylethylamine (PEA)

Answer 1

base structure for adrenergic agonists

Question 2

norepinephrine

Answer 2

nonselective adrenergic agonist
B1 preference
low affinity for B2

Question 3

epinephrine

Answer 3

nonselective agonist
B > a preference

Question 4

isoproterenol

Answer 4

PEA derivative
B selective (bulky R1) agonist

Question 5

methyl-DOPA

Answer 5

PEA derivative
prodrug for a-methyl norepinephrine
a2 selective agonist
antihypertensive

Question 6

metaproterenol

Answer 6

PEA derivative
B2 selective (bulky R1) agonist

Question 7

phenylephrine

Answer 7

PEA derivative
a selective agonist
for hypotension and nasal congestion

Question 8

L-DOPS

Answer 8

PEA derivative
nonselective adrenergic agonist
prodrug for norepinephrine
for orthostatic hypotension

Question 9

dipivefrin

Answer 9

PEA derivative
nonselective B agonist
prodrug for epinephrine

Question 10

lisdexamphetamine

Answer 10

PEA derivative
prodrug for dexamphetamine
nonselective adrenergic agonist
for ADHD

Question 11

ephedrine/pseudoephedrine

Answer 11

PEA derivative
nonselective adrenergic agonist
nasal decongestant

Question 12

midodrine

Answer 12

PEA derivative
prodrug
a1 selective agonist
for orthostatic hypotension

Question 13

isoproterenol

Answer 13

template 1 analog
nonselective B agonist
for heart block

Question 14

albuterol, terbutaline

Answer 14

template 1 derivative
B2 selective agonist
for asthma (short-acting)

Question 15

salmeterol, vilanterol, formoterol

Answer 15

template 1 analog
B2 selective agonist
for asthma (long-acting)

Question 16

indacaterol, olodaterol

Answer 16

template 1 analog
B2 selective agonist
for asthma (ultra long-acting)

Question 17

cocaine, amphetamines

Answer 17

PEA derivative
nonselective, indirect adrenergic agonist

Question 18

bupropion

Answer 18

PEA derivative
nonselective, indirect adrenergic agonist
for depression and smoking cessation

Question 19

oxymetazoline

Answer 19

template 2 analog
a1 selective agonist
for nasal congestion

Question 20

clonidine

Answer 20

template 2 analog
a2 selective agonist
INDIRECT a1 antagonist

Question 21

guanfacine

Answer 21

noncyclic template 2 analog
a2 selective agonist
ADHD

Question 22

prazosin

Answer 22

a1 selective antagonist
for hypertension

Question 23

terazosin, doxazosin

Answer 23

a1 selective antagonist
for hypertension + BPH

Question 24

alfuzosin, tamsulosin, silodosin

Answer 24

a1 selective antagonist
for BPH

Question 25

yohimbine

Answer 25

a2 selective antagonist for vet med

Question 26

reserpine

Answer 26

indirect adrenergic antagonist VMAT inhibitor

Question 27

deutetrabenazine

Answer 27

first FDA approved deuterated drug for Huntington's disease

Question 28

valbenazine

Answer 28

prodrug for tardive dyskinesia

Question 29

propranolol

Answer 29

aryloxypropanolamine template 1st generation nonselective B antagonist

Question 30

atenolol, metoprolol

Answer 30

aryloxypropanolamine template 2nd generation B1 selective antagonist

Question 31

carvedilol, labetalol

Answer 31

aryloxypropanolamine template 3rd generation mixed adrenergic antagonist (B1, B2, a1)

Question 32

timolol

Answer 32

no aryloxypropanolamine template nonselective B antagonist for glaucoma

Question 33

acetylcholine

Answer 33

nonselective cholinergic agonist miosis

Question 34

miochol E

Answer 34

acetylcholine salt form nonselective cholinergic agonist for miosis

Question 35

methacholine

Answer 35

acetylcholine derivative nonselective cholinergic agonist M preference for asthma test

Question 36

carbachol

Answer 36

acetylcholine derivative nonselective cholinergic agonist N preference for miosis

Question 37

bethanechol

Answer 37

acetylcholine derivative nonselective cholinergic agonist M preference for urinary retention

Question 38

tetra methyl ammonium

Answer 38

N selective agonist

Question 39

tetra ethyl ammonium

Answer 39

N selective antagonist

Question 40

hexa methonium

Answer 40

N ganglion blocker

Question 41

deca methonium

Answer 41

N depolarizing neuromuscular blocker cholinergic agonist for muscle relaxation

Question 42

succinylcholine

Answer 42

acetylcholine dimer N depolarizing neuromuscular blocker cholinergic agonist for muscle relaxation

Question 43

phenyl trimethyl ammonium

Answer 43

N selective agonist

Question 44

choline

Answer 44

N selective agonist choline reuptake inhibitor

Question 45

nicotine

Answer 45

N agonist for smoking cessation

Question 46

cytisine

Answer 46

N partial agonist for smoking cessation

Question 47

imidacloprid

Answer 47

N agonist for insecticide

Question 48

bupropion

Answer 48

N channel blocker for depression + smoking cessation

Question 49

mecamylamine

Answer 49

N channel blocker for hypertension

Question 50

tubocurarine, malouetine

Answer 50

natural product nondepolarizing skeletal neuromuscular blocker N cholinergic antagonist

Question 51

muscarine

Answer 51

natural product M selective agonist

Question 52

pilocarpine

Answer 52

natural product M selective agonist for glaucoma, xerostomia, Sjogren's

Question 53

cevimeline

Answer 53

M selective agonist for Sjogren's

Question 54

atropine

Answer 54

M selective antagonist for pre-op, cardiovascular, muscarine toxicity, mydriasis

Question 55

homatropine

Answer 55

M selective antagonist for ophthalmic

Question 56

ipratropium

Answer 56

M selective antagonist for bronchodilation

Question 57

tiotropium

Answer 57

M selective antagonist for bronchospasm

Question 58

trospium

Answer 58

M selective antagonist for urinary incontinence

Question 59

scopolamine

Answer 59

M selective antagonist for nausea, ophthalmic, antispastic

Question 60

methscopolamine

Answer 60

M selective antagonist for nasal decongestion, anticholinergic