ISLET CELL TUMORS

Question 1

name the different tumors

Answer 1

insulinoma
glucagonoma
VIPoma
somatostatinoma
Zollinger-Ellison syndrome

Question 2

glucagonoma

Answer 2

alpha cells
hyperglycemia
rash necrolytic migratory erythema

Question 3

insulinoma

Answer 3

beta cells
fasting hypoglycemia leads to mental status changes
increased insulin and C-peptide
*decreased C-peptide if insulin is high b/c of injections

Question 4

somatostatinoma

Answer 4

delta cells
lost of INHIBITION
1. gastrin - achlorhydria
2. secretin - steatorrhea ( no bicarb )
3. CCK - cholelithiasis + steatorrhea ( no pancreatic enzymes)
4. GIP - DM

Question 5

function of VIP

Answer 5

vasoactive inhibitory peptide

1. GI SM relaxation
2. increase heart contractility
3. H20 + electrolyte secretion in GI
4. glycogenolysis
5. vasodilation

Question 6

VIPoma

Answer 6

increase in vasoactive inhibitory peptide
*secretory diarrhea
(causes hypokalemia. normal ion gap metabolic acidosis)
hyperglycemia, decrease BP, achlorhydria

Question 7

somatostatin analogue

Answer 7

octreotide