Island EMS (Pharmacology)

Question 1

Tranexamic Acid

[Classification]

Answer 1

• Antifibrinolytic agent

Question 2

Tranexamic Acid

[Pharmacodynamics]

Answer 2

• Tranexamic acid is a synthetic derivative of the amino acid lysine that exerts its antifibrinolytic effect through the reversible blockade of lysine binding sites on plasminogen molecules

Question 3

Tranexamic Acid

[Contraindications]

Answer 3

• Hypersensitivity

-

Question 4

Tranexamic Acid

[Dosage]

Answer 4

• 1g IV/IO in 250ml D5W or NS over 10mins (OLMC) [ACP]

- Not to be repeated

Question 5

Tranexamic Acid

[Indications]

Answer 5

• Treatment of traumatic shock within 3hrs of initial injury and transport > 30mins (HR > 110bpm or SBP

Question 6

Tranexamic Acid

[Contraindications]

Answer 6

• Hypersensitivity

-

Question 7

Tranexamic Acid

[Contraindications]

Answer 7

• Hypersensitivity

-

Question 8

Tranexamic Acid

[Indications]

Answer 8

• Treatment of traumatic shock within 3hrs of initial injury (HR > 110bpm or SBP 30mins

Question 9

Tranexamic Acid

[Contraindications]

Answer 9

• Hypersensitivity
• Active thromboembolic disease (PE, DVT or CVA)
• Unable to initiate bolus within 3hrs of injury onset
• Consider administration to patients

Question 10

Tranexamic Acid

[Dosage]

Answer 10

• 1g IV/IO in 250ml D5W or NS over 10mins [ACP]

- Not to be repeated

Question 11

Tranexamic Acid

[Indications]

Answer 11

• Patients > 16 years within 3hrs of injury and presenting at any point with HR > 110bpm or SBP
• Consider for head injury or pelvic trauma with transport > 30mins