Ischemic Heart Disease Flashcards
What causes Ischemic Heart Disease? What are the risk factors?
Usually due to atherosclerosis of coronary arteries, which decreases blood flow to the myocardium. Same risk factors as atherosclerosis. Incidence increases with age.
A 45 year old male who was working out at the gym presents with chest pain that lasted for 15 minutes. He mentions it radiates to his left arm. He was experiencing shortness of breath and diaphoresis. It went away when he sat down to rest. What is causing this presentation? Which structures are damaged? What would you see on EKG? How is it treated? What does it increase the risk of?
Stable angina that arises with exertion or emotional stress. This is due to atherosclerosis of coronary arteries with > 70 % stenosis. Decreased blood flow is not able to meet the metabolic demands of the myocardium during exertion. EKG shows ST-segment depression due to subendocardial ischemia. Relived by rest or nitroglycerin.
What happens to myocytes in all angina forms?
Reversible injury without necrosis
What is unstable angina? What structures are involved? What is seen on EKG? How is it treated? What does it increase the risk of?
Chest pain that occurs at rest. Due to rupture of an atherosclerotic plaque with thrombosis and incomplete occlusion of a coronary artery. EKG shows ST-segment depression due to subendocardial ischemia. Relived by rest or nitroglycerin. High risk of progression to MI.
What is Prinzmetal angina? What structures are involved? What is seen on EKG? How is it treated?
Episodic chest pain unrelated to exertion. Due to coronary vasospasm. EKG shows ST-segment elevation due to transmural ischemia. Relived by nitroglycerin or calcium channel blockers.
A 45 year old male who was working out at the gym presents with chest pain that lasted for
Stable angina that arises with exertion or emotional stress. This is due to atherosclerosis of coronary arteries with > 70 % stenosis. Decreased blood flow is not able to meet the metabolic demands of the myocardium during exertion. EKG shows ST-segment depression due to subendocardial ischemia. Relived by rest or nitroglycerin.
What is Prinzmetal angina? What structures are involved? What is seen on EKG? How is it treated?
Episodic chest pain unrelated to exertion. Due to coronary vasospasm. EKG shows ST-segment elevation due to transmural ischemia. Relived by nitroglycerin or calcium channel blockers.
A 45 year old male who was working out at the gym presents with severe crushing chest pain that lasted for >20 minutes. He mentions it radiated to his left arm. He was experiencing shortness of breath and diaphoresis. He was given nitroglycerin but his symptoms did not resolve. What happened to him? What usually causes this? Which heart compartments are affected by this disorder?
He had a myocardial infarction which is necrosis of cardiac myocytes. Usually due to rupture of an atherosclerotic plaque with thrombosis and complete occlusion of a coronary artery. Infarction usually involves Left ventricle. RV and Atria are spared.
Besides atherosclerotic plaque, what are other causes of Myocardial Infarction?
Coronary artery vasosapsm (due to Prinzmetal angina or cocaine use), emboli, and vasculitis (e.g. Kawasaki disease)
What is the most commonly involved artery in MI? What does it lead to?
Left Anterior Descending artery. Leads to infarction of the anterior wall and anterior septum of the LV.
What is the second most commonly involved artery in MI? What does it lead to?
Right Coronary Artery leads to infarction of the posterior wall, posterior septum, and papillary muscles of the LV.
What does occlusion of the left circumflex artery lead to?
Infarction of the lateral wall of the LV
What does occlusion of the left circumflex artery lead to?
Infarction of the lateral wall of the LV
Which areas are damaged during the initial phase of myocardial infarction? What is seen on EKG?
Subendocardial necrosis involving
Which areas are damaged during the contunues/severe phase of myocardial infarction? What is seen on EKG?
Transmural necrosis involving most of the myocardial wall. EKG shows ST-segment elevation.