Ischemia/Infarction (Exam #2) Flashcards
What is the “path” of depolarization in heart tissue?
Endocardial → Epicardial (inner to outer)
What is the “path” of repolarization in heart tissue?
Epicardial → Endocardial (outer to inner)
Define Myocardial Ischemia. What general changes are seen (2)?
Ischemia = REVERSIBLE cell damage due to decreased O2
- ST segment changes
- T wave changes
What are the three criteria for Myocardial Ischemia (__ OR __ OR __)?
- ST segment depression OR - T wave inversion OR - Peaked/Symmetrical T waves
Define Myocardial Injury. What general changes are seen?
Injury = prolonged ischemia → further cell damage but NO cell death
- ST segment changes
What is the primary criteria for Myocardial Injury?
ST segment elevation
What other condition presents with T wave inversion, and how can you differentiate it from Transmural Ischemia?
Strain presents with T wave inversion but they are asymmetrical
- Transmural Ischemia = T wave inversion and SYMMETRICAL
What is seen with Subendocardial Ischemia?
Transient ST segment depression
What is seen with Transmural Ischemia?
Transient ST segment elevation
What causes the T wave inversion seen with Myocardial Ischemia?
Delayed repolarization
What causes the T wave changes seen when Subendocardial Ischemia progresses to Transmural Ischemia?
Reversal of repolarization causes T wave to invert and become symmetrical
What other condition presents with ST segment elevation, and how can you differentiate it from Myocardial Injury?
Pericarditis presents with DIFFUSE ST segment elevation
- Injury presents in respective leads (not diffuse)
Define Myocardial Infarction. What general changes are seen?
Infarction = cell death, enzymes released (T)
- Pathologic Q waves
What causes the development of pathologic Q waves?
Infarcted tissue is electrically silenced
What are the criteria for Q waves (__ AND __ AND __), and when do these present?
Myocardial Infarction - 0.04+ seconds in duration AND - At least 1/3 the height of R waves in same QRS complex AND - Present in 2+ contiguous leads