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BSMT IV > ISBB > Flashcards

ISBB Flashcards

1
Q

Normal serum proteins that can rapidly increase during an inflammation

A

Acute Phase Reactants

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2
Q

Concentration of CRP to be positive

A

0.6 mg/dL

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3
Q

Can be elevated during surgery and pregnancy

A

CRP

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4
Q

How much sample is needed in CRP/ASO/RF test

A

50 ul

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5
Q

Most widely used serological test for the detection of Group A hemolytic streptococcus infection

A

Anti-Streptolysin O Test

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6
Q

After how many minutes should CRP/ASO/RF be observed during testing?

A

2 minutes

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7
Q

Most common autoimmune disease; involves in the production of IgM or IgG antibodies against IgG

A

Rheumatoid Arthritis

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8
Q

Rheumatoid factors are directed against the ________ of the IgG molecules

A

Fc fragment

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9
Q

HIV strain most common in the USA

A

HIV-1

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10
Q

Test kit detects gp 36 for this type of HIV

A

HIV-2

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11
Q

Principle of HIV test kits

A

Lateral Flow Immunochromatography

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12
Q

Foundation of ISBB

A

Antigen-Antibody Interactions

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13
Q

Antigenicity Factors

A

Foreignness, Molecular Weight, Complexity

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14
Q

Most immunogenic composition

A

Proteins

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15
Q

Antibody class that exists as dimers in secretions

A

IgA

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16
Q

Antibody class conducive for agglutination

A

IgM

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17
Q

Prepared to provide accurate serum:cell ratio

A

Red Cell Suspensions

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18
Q

Excess antibody

A

Prozone

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19
Q

Formula for pRBC volume

A

%RBC * Total Volume

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20
Q

Grade agglutination: 2+

A

medium agglutinates

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21
Q

Simplest and most common application of Ag-Ab interaction

A

ABO/Rh Typing

22
Q

What is the recessive gene among ABO genes?

A

O gene

23
Q

Precursor antigen

A

H antigen

24
Q

RBC structure without antigen

A

glucose-galactose- N-acetylglucosamine -galactose

25
Q

Immunodominant sugar for A antigen

A

N-acetylgalactosamine

26
Q

If A antigen in present in the RBC, what antibody is present in the serum?

A

Anti-B

27
Q

Sample: red cells/ whole blood
Reagent: antisera
Tests for: antigens on RBCs

A

Forward Typing

28
Q

Anti-A - 4+
Anti-B - 4+
A Cells - 0
B Cells - 0

A

AB

29
Q

Problem with antibodies in reverse typing

A

Group I Discrepancies

30
Q

Less common discrepancy

A

Group II

31
Q

Seen in: Multiple myeloma, Waldenstrom’s macroglobulinemia, Wharton’s jelly

A

Group III

32
Q

Agglutinates A1 or A1B cells, but not A2

A

Dolichos biflorus

33
Q 
Expected Panel Result:
A Cells - 4+
B Cells - 4+
O cells - 4+
Anti-A - 0
Anti-B - 0
Autocontrol - 0
A

Bombay phenotype

34
Q

often associated with the diseases of the digestive tract

A

Acquired B phenomenon

35
Q

Unique Discrepancies

A
  1. Presence of A/B subgroups
  2. Bombay Phenotypes
  3. Acquired B Phenomenon
36
Q

ABO Discrepancies:

Mixed Field

A

Group O transfusions, stem cell transplant

37
Q

7 Physical Examination of Donors

A

Age, Weight, Pulse, Blood Pressure, Temperature, Hemoglobin, Hematocrit

38
Q

What does the primary capture antibody in test kits interact with?

A

Analyte (Ag)

39
Q

T or F: Presence of two bands in HIV test kits indicates co-infection

A

False

40
Q

T or F: In the absence of HbsAg, presence of Anti-Hbc indicates immunity.

A

False. It indicates recovery.

41
Q

Marker of immunity

A

Anti-Hbs

42
Q

RPR result:

large and medium black floccules against white background

A

Reactive

43
Q

Often used to obtain titers

A

Serial dilution

44
Q

Blood bag anticoagulant component that is a substitute for ATP production

A

Dextrose

45
Q

Some are termed as non-agglutination / incomplete antibodies

A

IgG

46
Q

Last check of ABO compatibility

A

Crossmatching

47
Q

Phase that detects ABO incompatibilities

A

Immediate Saline Spin Phase

48
Q

Causes of Positive Crossmatch

A
  1. Incorrect ABO Grouping
  2. Presence of alloantibodies (ac - neg)
  3. Presence of autoantibodies (ac - pos)
  4. Proteins coating donor RBCs
  5. Abnormalities in plasma
49
Q

How many minutes should RPR be read? What should be observed?

A

Observed for flocculation within 8 minutes.

50
Q

Antigen detected within first 1-9 days of dengue infection

A

NS1 antigen

BSMT IV (1 decks)

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