Iron deficiency Anaemia

Question 1

Iron absorption

Answer 1

Iron absorbed in duodenum fe 2+ via DMT1
ferroportin transports iron into blood stream
converted back to fe3+ and bound by transferrin

hepcidin is a negative regulator of ferrportin

iron stored by liver and macrophages. express transferrin receptor

released in response to low hepcidin via ferroportin

loss of iron through loss of gi epithelial cells

Question 2

Iron deficiency

Answer 2

reduced iron intake

microcytic cells
low iron
low transferrin saturation
low ferritin

Question 3

Causes of iron deficiency

Answer 3

bleeding
decreased intake
decreased absorption

Question 4

Treatment of iron deficiency

Answer 4

iron replacement orval vs IV

transfusion