Iron

Question 1

Most common cause of IDA in woman is

Answer 1

Lack of iron in diet

Question 2

Heamoglobin contain iron in amount of

Answer 2

2.5 g

Question 3

Iron metabolism in the body is ——— system

Answer 3

Closed

Question 4

Normal diet contains about — of iron / day

Answer 4

15mg

Question 5

Iron is absorbed in oxidised form / t or f

Answer 5

F / in reduced form

Question 6

What are substances that decrease the absorption of iron

Answer 6

Phytates , tannates , anti acids , tea , coffee, milk

Question 7

What are pathways to exclude the iron

Answer 7

Sloughing of dead cells
Iron excretion in bile

Question 8

In woman additional ——- of iron is loses monthly

Answer 8

30 mg

Question 9

Why free iron must be bound to protein

Answer 9

Because it insoluble or toxic or may be cause free radicles that damage the cells

Question 10

Heam : iron inserted in a ——

Answer 10

Tetrapyrrole ring

Question 11

Most abundant heamoprotein in the liver

Answer 11

Cytochrome p450 about 1mg

Question 12

Most sensitive and reflected iron storage in the body

Answer 12

Ferritin

Question 13

Feritten can store about of ——— of iron ion in the form of ——-

Answer 13

4500 - fe+3

Question 14

The only source of iron heamoglobin and can bound to —— atoms of iron

Answer 14

Transferrin -2

Question 15

What is the most important iron carrier in blood

Answer 15

Transferrin

Question 16

The production of transferrin through

Answer 16

Liver

Question 17

Transferrin bound to ferrous -t or f

Answer 17

F / to the ferric

Question 18

Transferrin saturation is

Answer 18

30 -50%

Question 19

Transferrin saturation under —- is indicator for iron deficiency

Answer 19

15%

Question 20

Transferrin iron complex is endocytosed by

Answer 20

He producing cells after linking to receptors

Question 21

Increased absorption of iron from the gut

Answer 21

Heamochromatosis

Question 22

Decreased in amount of iron in the body’s

Answer 22

Iron diffiency anemia

Question 23

Inflammation induced change of iron distribution

Answer 23

Anemia of chronic disease

Question 24

What is the therapy of IDA

Answer 24

Phlebotomy

Question 25

Most common anemia

Answer 25

IDA

Question 26

What are manifestations of IDA

Answer 26

Hypochromic microcytic erythrocytes

Question 27

Iron is transported from the cell by

Answer 27

Ferroportin

Question 28

Which cells must able to export iron

Answer 28

Macrophages ( recycle 30 mg ) from erythrocytes
Enterocytes ( export 1mg ) from diet
Hepatocytes ( mobilise stored iron form ferritin )

Question 29

Hepcidine produced from

Answer 29

Liver

Question 30

What is the function of hepcidine

Answer 30

Blocks iron export from macrophages and enterocytes in small intestine

Question 31

Increase erythropoiesis —————- hepcidine expression

Answer 31

Decrease

Question 32

Inflammation ———— hepcidine synthesis

Answer 32

Increase

Question 33

Iron overload

Answer 33

Increase hepcidine production

Question 34

IDA ——— hepcidine production

Answer 34

Decrease

Question 35

IDA cause ————- TIBC

Answer 35

Increase