Iron Flashcards
Most common cause of IDA in woman is
Lack of iron in diet
Heamoglobin contain iron in amount of
2.5 g
Iron metabolism in the body is ——— system
Closed
Normal diet contains about — of iron / day
15mg
Iron is absorbed in oxidised form / t or f
F / in reduced form
What are substances that decrease the absorption of iron
Phytates , tannates , anti acids , tea , coffee, milk
What are pathways to exclude the iron
Sloughing of dead cells
Iron excretion in bile
In woman additional ——- of iron is loses monthly
30 mg
Why free iron must be bound to protein
Because it insoluble or toxic or may be cause free radicles that damage the cells
Heam : iron inserted in a ——
Tetrapyrrole ring
Most abundant heamoprotein in the liver
Cytochrome p450 about 1mg
Most sensitive and reflected iron storage in the body
Ferritin
Feritten can store about of ——— of iron ion in the form of ——-
4500 - fe+3
The only source of iron heamoglobin and can bound to —— atoms of iron
Transferrin -2
What is the most important iron carrier in blood
Transferrin
The production of transferrin through
Liver
Transferrin bound to ferrous -t or f
F / to the ferric
Transferrin saturation is
30 -50%
Transferrin saturation under —- is indicator for iron deficiency
15%
Transferrin iron complex is endocytosed by
He producing cells after linking to receptors
Increased absorption of iron from the gut
Heamochromatosis
Decreased in amount of iron in the body’s
Iron diffiency anemia
Inflammation induced change of iron distribution
Anemia of chronic disease
What is the therapy of IDA
Phlebotomy
Most common anemia
IDA
What are manifestations of IDA
Hypochromic microcytic erythrocytes
Iron is transported from the cell by
Ferroportin
Which cells must able to export iron
Macrophages ( recycle 30 mg ) from erythrocytes
Enterocytes ( export 1mg ) from diet
Hepatocytes ( mobilise stored iron form ferritin )
Hepcidine produced from
Liver
What is the function of hepcidine
Blocks iron export from macrophages and enterocytes in small intestine
Increase erythropoiesis —————- hepcidine expression
Decrease
Inflammation ———— hepcidine synthesis
Increase
Iron overload
Increase hepcidine production
IDA ——— hepcidine production
Decrease
IDA cause ————- TIBC
Increase
