iRAT 2

Question 1

First generation cephalosporins

Answer 1

Oral: cephalexin, cefadroxil
Parenteral: cefazolin

Question 2

Second generation cephalosporins

Answer 2

Oral: cefprozil, cefuroxime axetil
Parenteral: cefuroxime, cefotetan, cefoxitin
*grouped as cephamycins: have activity against anaerobes

Question 3

Third generation cephalosporins

Answer 3

Oral: cefdinir, cefditoren, cefpodoxime, ceftibuten
Parenteral: cefotaxime, ceftazidime, ceftriaxone

Question 4

Fourth generation cephalosporins

Answer 4

Parenteral: cefepime

Question 5

Fifth generation cephalosporins

Answer 5

Parenteral: ceftaroline

Question 6

1st generation bacterial coverage

Answer 6

Gram positive: staphylococci (MSSA), streptococci

Gram negative: Proteus mirabilis, E. coli, Klebsiella sp. (PEK)

Question 7

2nd generation bacterial coverage

Answer 7

Gram positive: staphylococci (MSSA), streptococci

Gram negative: Haemophilus, Neisseria sp., Proteus mirabilis, E. coli, Klebsiella sp. (HNPEK)

Question 8

3rd generation bacterial coverage

Answer 8

Gram positive: staphylococci (MSSA), streptococci (S. pneumoniae)
Gram negative: better HNPEK coverage

Question 9

4th generation bacterial coverage

Answer 9

Gram positive: staphylococci (MSSA), streptococci

Gram negative: HNPEK + Serratia (HNPEKS) + Citrobacter, Acinetobacter, Pseudomonas, Enterobacter sp. (CAPE)

Question 10

5th generation bacterial coverage

Answer 10

Gram positive: staphylococci (MSSA & MRSA), streptococci

Gram negative: HNPEK