ion channels overview Flashcards
What are the steps in APs?
sept 1-4
1) Na channels open first (depolarization)
2) K channels open more slowly (repolarization)
3) Na channels close
- absolute refactory period caused by inactivation of Na channels
4) K channels close slowly
- results in after hyperpolarization
Cav channel mustations result in many diseases name 7
Epilepsy
Autism
familial hemiplegic migraine type-1
episodic Ataxia type 2
spinocerebellar ataxia type-6
incomplete x-linked congenital stationary night blindness
x linked cone rod dystrophy
hypokalemic periodic paralysis
malignant hyperthermina suseptibility
timothy syndrom
brugada syndrom
sinoatrial node dysfunction and deafness
what are Nav channel diseases
1 mild
2 moderate
and 5 severe
febrile seizures
febril seizures
generalized seizures
febrile seizures generalized seizures myoclonic seizures atypical absense seizures ataxia cognitive impairment
Ligand gated ion channels
Cys-loop receptor (nicotinic ACh) superfamily
GIVE ME SOME CHARACTERISTICS
AND SOME EXAMPLES
pentamer
Nicotinic Ach receptos 5-HT receptor GABA Glycine ZAC
Ligand gated ion channels
Glutamate receptor family
Characteristics and examples please and thank you
tetramer
NMDA
AMPA
Kainate
Ligand gated ion channels
P2X receptor family
Characteristics and example
trimer
P2x receptor
Ionotropic Glutamate receptor
AMPA
GluA1-GluA4
GRIA1-GRIA4
Ionotropic Glutamate receptor
Kainate
GluK1-GluK5
GRIK1-GRIK5
Ionotropic Glutamate receptor
NMDA
GluN1
GluN2A-GluN2D
GRIN1
GRIN2A-GRIN2D
Ionotropic Glutamate receptor
Orphan
GluD
GluD1
GluD2
GRID1
GRID2
What are 4 examples of cys-looped superfamily of receptors or pentameric ligand gated ion channels
nicotinic Ach
5-HT
GABA
glycine
NAchR
Muscle nAChR
alpha beta Y/E Delta
Neuronal nAChR
alpha2-Alpha6
Beta2-Beta4
Alpha7-Apla10
