Ion Channels and Ionotropic Receptor Drugs

Question 1

Modulators of Na+ channel inactivation

Answer 1

Carbamazepine, phenytoin, lamotrigine, oxcarbazepine, zonisamide

Question 2

T-type Ca++ channel inhibitors

Answer 2

Ethosuximide

Question 3

K+ channel facilitators

Answer 3

Retigabine/ezogabine (not used)

Question 4

Enhancers of GABA neurotransmission

Answer 4

Benzodiazepines (clonazepam, lorazepam, diazepam)
Barbiturates (pentobarbital)

Question 5

Drugs that increase extracellular GABA

Answer 5

Tiagabine, vigabtrin

Question 6

Inhibitors of synaptic transmission

Answer 6

GABA analogs (gabapentin, pregalabin)
Levetiracetam

Question 7

Excitatory postsynaptic receptor blockers

Answer 7

Perampanel

Question 8

ASDs with unclear mechanisms

Answer 8

Valproic acid, topiramate

Question 9

Dravet and Lennox-Gastaut specific ASDs

Answer 9

Fenfluramine, cannabidiol

Question 10

Tuberous sclerosis specific ASDs

Answer 10

Everolimus