IO Lingo

Question 1

what is a hazard ratio

Answer 1

the likelihood of an event occurring when comparing two different treatments/groups
Ex: if the hazard ratio for disease recurrence for treatment A compared to treatment B is 0.75, then the risk of disease recurrence is lower in the treatment A group compared to B group. The HR of 0.75 means that the patients receiving treatment A have a 25% lower risk of disease recurrence at any given time point during the study period compared to treatment B.

Question 2

what does “open label” study mean

Answer 2

clinical trial or research study in which both the researchers and the participants are fully aware of the treatment being administered. There is no blinding.

Question 3

objective response rate vs. disease control rate

Answer 3

objective response rate = complete response + partial response

disease control rate = complete response + partial response + stable disease