Investigations Flashcards
1
Q
What rises in hepatocellular injury?
A
- ALT + AST
- (this is a hepatic picture)
2
Q
What is the elevation pattern in acute and chronic hepatocellular injury?
A
- Acute: very elevated
- Chronic: mildly elevated
3
Q
AST>ALT in 2:1 ratio suggests?
A
Alcoholic liver disease/alcoholic hepatitis
4
Q
ALP is an indirect marker of what?
A
- Cholestasis
- (Non-specific: also raised in bone disease, renal disease, lymphoma, myeloma, T3 of pregnancy)
5
Q
An isolated rise in GGT suggests what?
A
- Chronic alcohol excess
- (Non-specific: also raised in COPD, renal failure, post MI, and hepatic malignancy)
6
Q
Elevated ALP and GGT in 3:1 ratio indicates what?
A
Cholestasis
7
Q
Features of pre-hepatic jaundice?
A
- Isolated rise in bilirubin
- Normal urine
- Normal stools
8
Q
Features of hepatic jaundice?
A
- Rise in ALT/AST > ALP/GGT
- Dark urine
- Normal stool
9
Q
Features of post-hepatic jaundice?
A
- Rise in ALP/GGT >AST/ALT
- Dark urine
- Pale stool
10
Q
Investigation for abnormal LFTs with no clear cause?
A
Non-invasive liver screen
