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PMLS > Inventions and Innovations in the Field of Medical Laboratory (NOT IN THE BOOK)) > Flashcards

Inventions and Innovations in the Field of Medical Laboratory (NOT IN THE BOOK)) Flashcards

1
Q

Discovered the circulation of blood

A

William Harvey (1578-1657)

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2
Q

Used microscope to document the existence of “cells”

A

Robert Hooke (1635-1703)

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3
Q

Father of Histology

A

Marcello Malpighi (1628-1694)

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4
Q

Proved that urine protein would form a precipitate when boiled with acetic acid

A

Frederik Dekkers (1694)

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5
Q

First to notice the characteristic sweet taste of diabetic urine (as it was infused with honey or sugar)

A

Thomas Willis (1621-1675)

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6
Q

First to perform direct transfusion pf blood from one animal to another

A

Richard Lower (1631-1691)

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7
Q

Father of Hematology and discovered coagulation

A

William Hewson (1739-1774)

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8
Q

Develops the mercury thermometer and the Fahrenheit temp scale

A

Gabriel Fahrenheit (1714)

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9
Q

Introduced a method of obtaining specimens for microscopic study

A

John Hill (1770)

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10
Q

Observed sediments in the urine of febrile patients

A

J. W. Tichy (1774)

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11
Q

Proved that sweetness of the urine and blood serum in diabetes is caused by sugar

A

Matthew Dobson (1776)

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12
Q

Developed yeast test for sugar determination in diabetic urine

A

Francis Home (1780)

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13
Q

Discovered cholesterol

A

Antoine Francois de Fourcroy (1789)

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14
Q

Pioneered in the use of microscope and description of the germinal vesicle in the embryo, description and naming of protoplasm, discovery of the sudoriferous glands of the skin and their excretory ducts

A

Johannes Evangelista Purkinje (19th century)

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15
Q

Studied the great cholera outbreak in London

A

John Snow (1854)

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16
Q

Discovered coagulation time as an index of blood coagulation

A

Karl Von Vierordt (1877)

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17
Q

Observed the role of calcium salts in the coagulation of blood

A

Sir Almroth Edward Write (1879)

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18
Q

Developed methods of drying and fixing blood smears using heat and discovered mast cells and classified white blood cells according to its granulation

A

Paul Ehrlich (1879)

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19
Q

Discovered penicillin (paramount in initiating the antibiotic era)

A

Alexander Fleming (1928)

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20
Q

Performed the first chemical analysis of proteins

A

Gerardus Mulder (1830)

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21
Q

Developed an achromatic microscope and introduced dark-field microscopy

A

Joseph Jackson Lister (1830)

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22
Q

Developed a standard test for arsenic

A

James Marsh (1836)

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23
Q

Developed a method for performing accurate blood counts (hemocytometry)

A

Jarl Von Vierordt (1852)

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24
Q

Discovered flourescence

A

George Gabriel Stokes (1852)

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25
Q

Prepared the first synthetic dye

A

William Perkin (1852)

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26
Q

Developed the first visual colorimeter based on Beer’s Law

A

Jules Duboscq (1854)

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27
Q

Invented the glass hypodermic syringe

A

Herman Luer (1869)

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28
Q

Developed the use of a gelatin for isolation of fungi

A

Oscar Brefeld (1872)

29
Q

Established the first public health lab in England

A

William Henry Cornfield (1875)

30
Q

Developed the alkaline picrate method for the determination of creatinine

A

Max Jaffe (1886)

31
Q

Invented the vacuum flask

A

James Dewar (1892)

32
Q

Invented the photoelectric cell

A

Julius Elster and Hans Friedrich Geitel (1893)

33
Q

Invented the nephelometer (an instrument for measuring the size and concentration of particles suspended in a liquid or gas, especially by means of the light they scatter)

A

Theodore Richards (1893)

34
Q

Produced their modification of the acid-fast stain for tuberculosis

A

Franz Ziehl and Friendrich Neelsen (1895)

35
Q

Published Practical Urinalysis and Urinary Diagnosis

A

Charles Purdy (1896)

36
Q

Developed the agglutination test for identification of the typhoid bacillus

A

Ferdinand Widal (1896)

37
Q

Discovered the reciprocal relationship between pH and oxygen content of hemoglobin (Bohr effect)

A

Christian Bohr (1902)

38
Q

Obtained the first pure culture of the sulfur-oxidizing bacterium

A

Martinus Beijerinck (1902)

39
Q

Discovered immunodiffusion

A

H. J. Bechtold (1905)

40
Q

Published the first edition of Diagnosis by Laboratory Methods

A

Arthur Sanford and James Todd (1908)

41
Q

Invented the fluorescence microscope

A

Oskar Heimstadlt. (1911)

42
Q

Developed the colorimeter-nephelometer

A

Philip Adolf Kober (1916)

43
Q

Developed the mass spectrograph

A

Francis William Aston (1919)

44
Q

Developed moving boundary electrophoresis of proteins

A

Arne Tiselius (1896)

45
Q

Determined the molecular weight of hemoglobin by ultracentrifugation

A

Theodore Svenberg (1896)

46
Q

Reported the ability to recover cancer in vaginal smears

A

George Nicholas Papanicolaou (1928)

47
Q

Introduced the use of light filter in colorimetry

A

Otto Folin (1929)

48
Q

Develops the erythrocyte sedimentation rate (ESR) as an index of severity of disease

A

R. Gabreus (1929)

49
Q

Developed the first clinical laboratory method for alkaline phosphate (Clinical Enzymology)

A

H. D Kay (1930)

50
Q

Developed the first clinical lab method for serum lipase activity

A

Ian Cherry and Lathan Crandall (1932)

51
Q

Developed 2 major clinical lab methods for serum and urine amylase activity

A

Michael Somogyi (1938)

52
Q

Developed the first essay for acid phosphatase

A

Alexander Gutman (1938)

53
Q

Developed the first clinical lab method for ammonia

A

Edward Joseph Conway and Robert Cooke

54
Q

Developed the whole blood clotting time test

A

S. Borgstrom

55
Q

Developed radioimmunoassay

A

Rosalyn Yalow and Solomon Berson

56
Q

Invented immunoelectrophoresis

A

Miroslav Poulik

57
Q

Developed the atomic absorption spectrometer

A

Alan Walsh

58
Q

Developed the method for serum lactate dehydrogenase, serum alanine aminotransferase

A

Felix Wroblewski and John Ladue

59
Q

Developed a direct chemical method for the determination of triglycerides

A

Emile Van Handel and Don Zilversmit

60
Q

Introduced Westgard control rules into clinical laboratory quality control

A

James Westgard

61
Q

Introduced Prostate Specific Antigen (PSA) as a serum tumor marker

A

M. C. Yank

62
Q

Discovered CA-72 (colorectal cancer)

A

David Colcher (1980)

63
Q

Discovered CA 19-9 (pancreatic cancer)

A

Hilary Koprowski (1981)

64
Q

Discovered CA- 125 (ovarian cancer)

A

Robert Bast Jr. (1981)

65
Q

Discovered CA-50 (colorectal cancer)

A

L. Lindholm

66
Q

Discovered CA- 15-3 (breast cancer)

A

R. Tobias (1985)

67
Q

Discovered CA 549 (breast cancer)

A

Kurt Bray (1987)

68
Q

Discovered CA- 195 (colorectal cancer)

A

S. Fukuta (1987)

PMLS (5 decks)

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