Invasion and Metastasis

Question 1

https://www.nature.com/onc/journal/v27/n37/full/onc2008140a.html

Answer 1

yes

Question 2

What are the key steps in the mechanism of invasion?

Answer 2

>Detachment from Tumour Mass
> Motility
>Movement through stroma/mesenchyme
>Intravasation
>Extravasation

Question 3

Which membrane-bound molecule is responsible for anchorage between cells?

Answer 3

E-cadherin

Question 4

Macrophages recruited by CSF cleave the junctions between cells by what pathway?

Answer 4

A positive feedback loop using EGF to trigger the release of Cathespin-B.