Intxn Flashcards
What are the major CYP inhibitors
Remember G <3 PACMAN
- Grapefruit
- <3
- Protease inhibitors (PI), especially ritonavir (Norvir)
- Azole antifungals (fluconazole, itraconazole, ketoconazole, posaconazole (Noxafil), voriconazole, and isavuconazonium (Cresemba))
- Cyclosporine, cimetidine (Tagamet), cobicistat
- Macrolides (clarithromycin (Biaxin) and erythromycin, but not azithromycin)
- Amiodarone (and dronedarone (Multaq))
- Non-DHP CCBs (diltiazem and verapamil)
What are the major CYP inducers
Remember SSR COPP
- St. John’s Wort
- Smoking
- Rifampin (and rifabutin, rifapentine)
- Carbamazepine (also an auto-inducer)
- Oxcarbazepine (and eslicarbazepine)
- Phenytoin-
- Phenobarbital-
What are the major CYP Substrate A
Anticoagulants
* Warfarin (VKOR)
* Apixaban (Eliquis)
* Rivaroxaban (Xarelto)
Antiplatelet - ticagrelor (Brilinta)
Antipsychotics - aripiprazole (Abilify)
Amiodarone (Nextreon, Pacerone)
What are the major CYP Substrate B
Benzo
Except: LOT - also rec for elderly
Lorazepam
Oxazepam
Temazepam
What are the major CYP Substrate C
Carbamazepine (Tegretol) - auto induction (makes itself go down)
Colchicine (Colcrys)
CCB
What are the major CYP Substrate D
(-done) - pain meds ending w/ -done
* Oxycodone
* Methadone - QT prolongation
* Hydrocodone
Daliresp (Roflumilast)
Dronedarone (Multaq)
What are the major CYP Substrate E
Estrogen
ED drugs
What are the major CYP Substrate F
Fentanyl
What are the major CYP Substrate G
Gleevec (imatinib): all -tinib (tyrosine kinase inhibitors)
What are the major CYP Substrate H
HIV: PI - LAND FIRST (-navir)
What are the major CYP Substrate I
Immunosuppressants:
Tacrolimus (Prograf, Astagraf XL; Protopic - for eczema)
Cyclosporine
* IV (Sadimmune)
* PO (Neural, Gengraf)
* Eye Drops - on the shelf
* - Restasis
* - Cequar
What are the major CYP Substrate S
S - statins, LAS
