Introduction to the Nervous System and Neurology Flashcards

1
Q

What are the components of the nervous system?

A

Brain, spinal cord and nerve cells

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2
Q

What do nerve cells do?

A

They generate electrical signals

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3
Q

What is the cell body of a neuron?

A

It is what contains all the normal machinery of life

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4
Q

What is the function of the dendrites found on neurones?

A

To provide a large surface area for receiving information from other cells

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5
Q

What is the function of the axon of a neuron?

A

It transmits information to other nerve cells using action potentials

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6
Q

What is a synapse?

A

It is where one nerve cell passes information to another nerve cell by releasing neurotransmitters into the synaptic cleft which attach onto receptors and pass on the action potential

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7
Q

What is the function of the cerebrospinal fluid?

A

To act as a shock-absorber

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8
Q

What physical support/protection does the nervous system have?

A
  • Meninges
  • CSF
  • Highly specialised capillaries with few gaps in their walls so nothing can diffuse through them
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9
Q

What defence does the nervous system have?

A

Microglia, blood-brain barrier and glial cells

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10
Q

What is the function of microglia?

A

It protects the brain against infection- part of the innate immune system

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11
Q

Where do glial cells come from?

A

The same stem cells as nerve cells

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12
Q

What is the function of glial cells?

A

To provide biochemical and structural support for nerve cells and helps control the activity of nerve cells

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13
Q

What is the function of astrocytes?

A
  • Keeping the concentration of ions just right to allow optimal function of nerve cells
  • Transport of nutrients and waste products between nerve cells and blood vessels
  • Clear synaptic cleft for incoming action potentials
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14
Q

What is the structure of astrocytes?

A

They have long processes that come out of the cell body, processes form sheets that sheath the dendrites and cell bodies of nerve cells

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15
Q

What forms the blood-brain barrier?

A

The contact between astrocytes and capillaries

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16
Q

What are the 2 types of myelinated glial cells and what do they form?

A

Neurolemmocytes and oligodendrocytes

Form a sheath around each axon

17
Q

Where is grey matter found?

A

Outside of white matter

18
Q

What does grey matter contain?

A
  • Cell bodies
  • Dendrites
  • Local axons
  • Supporting astrocytes
19
Q

What is white matter?

A

Bundles of axons linking different grey matter regions

20
Q

What does white matter contain?

A
  • Oligodendrocytes

- Astrocytes

21
Q

What do afferent neurones do?

A

They carry information from sensory nerves to the CNS

22
Q

What do efferent neurones do?

A

They carry signals from the CNS to motor nerve

23
Q

What are pathways?

A

A chain of nerve cells that carry specific information

24
Q

What are tracts?

A

Regions of white matter through which identified pathways run

25
Q

What are the 2 main divisions of the nervous system?

A

Central and peripheral

26
Q

What protects the CNS?

A

Cranium and vertebral column

27
Q

Where do aneurysms mainly arise?

A

In the Circle of Willis

28
Q

What is the name of the background potential that electrical signals are generated against?

A

Resting Membrane Potential (RMP)

29
Q

What is the general value for RMP?

A

-60mV/-70mV

30
Q

What produces RMP?

A

Generated as cell membranes are more permeable to K+ which means K+ diffuses out of cells
This leaves an excessive negative charge inside

31
Q

What can increase the RMP and how?

A
  • Kidney disease
  • Major soft tissue damage
  • Medication error
  • All of these increase K+ concentration gradient
32
Q

When does an action potential occur?

A

When there’s an increase in permeability to Na+

33
Q

What happens as a result of increased permeability to Na+?

A

-Na+ diffuses into the cell making the inside more positive= depolarisation

34
Q

How is RMP restored?

A

By the diffusion of extra K+ out of the cell, making the inside more negative again= repolarisation

35
Q

Why does hyperpolarisation occur?

A

As the K+-voltage gated channels are slow to close so more K+ diffuses out of the cell

36
Q

What causes the release of neurotransmitters from the pre-synaptic bouton into the synaptic cleft?

A

Depolarisation of the synaptic bouton

37
Q

What does the effect of a neurotransmitter on a synapse depend on?

A

The receptor used

38
Q

What can the different effects on a synapse be classified as?

A
  • Excitatory/inhibitory
  • Fast/slow
  • Trasient/persistent
39
Q

How do drugs effect synaptic transmission?

A

They interfere with:

  • neurotransmitter production/release
  • neurotransmitter receptors
  • neurotransmitter removal