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Physical Pharmacy > INTRODUCTION TO PHYSICAL PHARMACY > Flashcards

INTRODUCTION TO PHYSICAL PHARMACY Flashcards

1
Q

deals with:
* Investigations of physical and chemical
ppts. of drug molecules;

A

PHARMACEUTICS

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2
Q

deals with:
Design, fabrication, and evaluation of DDS
(Drug Delivery System)

A

PHARMACEUTICS

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3
Q

deals with:
Monitoring how drug products are ADME in
the body

A

PHARMACEUTICS

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4
Q

(Study of ADME)
K - katawan

A

Pharmaco(K)inetics

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4
Q

DDS

A

Drug Delivery System

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5
Q

ADME

A

Absorption, Distribution, Metabolism, Excretion

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6
Q

(Bioavailability)
study of the factors influencing the bioavailability of a drug in humans and animals, and the information to optimize the therapeutic activity of the drug products

B - biogesic -> what the drug does to the body

A

(B)iopharmaceutics

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7
Q

art and science of formulation and manufacture of DF (Drug Formulation) & DDS (Drug Delivery System)

A

Dosage Forms

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8
Q

deals with the physicochemical properties underlying the development of a successful DF.

A

Physical Pharmacy

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9
Q

A fundamental unit relating each measurable quantity to some natural/ artificial constant in the universe.

A

Reference Standard

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10
Q

CGS UNIT
Length

A

cm (centimeter)

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11
Q

CGS UNIT
Mass

A

g (gram)

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12
Q

CGS UNIT
Time

A

s (seconds)

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13
Q

SI UNIT
Length

A

m

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14
Q

SI UNIT
Mass

A

kg

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15
Q

SI UNIT
Time

A

s

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16
Q

REF. STD.
Length

A

meter

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17
Q

REF. STD.
Mass

A

kilogram

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18
Q

REF. STD.
Time

A

Atomic Frequency

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19
Q

Metric System
Weight

A

g (gram)

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20
Q

Metric System
Volume

A

L or l (liters)

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21
Q

Metric System Length

A

m (meter)

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22
Q
  • the forces between molecules or compounds
  • Inter means between or among
A

Intermolecular Binding Forces

22
Q
  • covalent bonds within molecule
  • strong bonds
  • delta H bond (HCl) = 431 kJ / mol
A

Intramolecular forces

23
Q
  • intra means within
  • forces within molecules or forces between atoms

e.g covalent, metallic or ionic

A

Intramolecular Binding Forces

24
Q
  • attraction forces between molecules
  • weak bonds
  • delta H vaporizarization (HCl) = 16 kJ / mol
A

Intermolecular forces

25
Q

attraction between “unlike” molecules

A

Adhesion

25
Q

like poles repel
opposite poles attract

A

Magnetic forces

26
Q

like charges repel
opposite charges attract

A

Electrostatic forces

26
Q

are inversely proportioned to the distance separating the molecule

A

Attractive forces (FA)

26
Q

INTERMOLECULAR ATTRACTIVE FORCES
van der Waals Forces:

A
  1. DIPOLE-DIPOLE FORCES or ORIENTATION EFFECT, KEESOM FORCES
  2. DIPOLE-INDUCED DIPOLE FORCES or INDUCTION EFFECT, DEBYE FORCES
  3. INDUCED DIPOLE-INDUCED DIPOLE OR DISPERSION FORCES, LONDON FORCES
  4. ION-DIPOLE FORCES
  5. ION-ION INTERACTIONS
  6. THE HYDROGEN BOND
27
Q

attraction between “like” molecules

A

Cohesion

27
Q

The energy of this type of attractive force is 1 to 3 kcal/mole

A

DIPOLE-INDUCED DIPOLE FORCES or INDUCTION EFFECT, DEBYE FORCES

28
Q

are proportional to an exponential relationship with the reciprocal of the distance separating the molecules.

A

Repulsive forces (FR)

28
Q

possessing “permanent dipoles”, having both a partial positively charged end and a partial negatively charged end:

POLAR & POLAR

A

DIPOLE-DIPOLE FORCES or ORIENTATION EFFECT, KEESOM FORCES

28
Q

Easily polarized molecules include ethylacetate, methylene chloride, and ether

A

DIPOLE-INDUCED DIPOLE FORCES or INDUCTION EFFECT, DEBYE FORCES

28
Q

Molecules that possess permanent dipoles include water, hydrochloric acid, alcohol, acetone, and phenol

A

DIPOLE-DIPOLE FORCES or ORIENTATION EFFECT, KEESOM FORCES

29
Q

A polar molecule can produce a temporary electric dipole in nonpolar molecules that are easily polarizable:

POLAR & NON-POLAR

A

DIPOLE-INDUCED DIPOLE FORCES or INDUCTION EFFECT, DEBYE FORCES

29
Q

The energy of this attraction ranges from 1 to 7 kcal/mole

A

DIPOLE-DIPOLE FORCES or ORIENTATION EFFECT, KEESOM FORCES

29
Q

Keesom
AKA as

A

Dipole-Dipole Forces or Orientation Effect

Polar-Polar

30
Q

This attraction is produced by asymmetry in the distribution of the electrons around the nucleus; temporary.

A

INDUCED DIPOLE-INDUCED DIPOLE OR DISPERSION FORCES, LONDON FORCES

30
Q

This force is responsible for the liquefaction of gases:

NON- POLAR & NON-POLAR.

A

INDUCED DIPOLE-INDUCED DIPOLE OR DISPERSION FORCES, LONDON FORCES

31
Q

Nonpolar molecules exhibiting induced dipole-induced dipole forces of attraction include organic compounds such as carbon disulfide, carbon tetrachloride, and hexane.

A

INDUCED DIPOLE-INDUCED DIPOLE OR DISPERSION FORCES, LONDON FORCES

31
Q

The energy of this attractive force is 0.5 to 1 kcal/mole

A

INDUCED DIPOLE-INDUCED DIPOLE OR DISPERSION FORCES, LONDON FORCES

32
Q

Debye
AKA as

A

Dipole-induced or Induction Effect

Polar-Non Polar

33
Q

London
AKA as

A

Induced Dipole - Induced Dipole or Dispersion Forces

Non Polar - Non Polar

34
Q

Attractive force that results from the electrostatic attraction b/n an ion and neutral molecules that has a dipole

A

ION-DIPOLE FORCES

35
Q

Found in solutions (specifically solutions of ionic compounds)

A

ION-DIPOLE FORCES

36
Q

Diuretics

A

ION-DIPOLE FORCES

37
Q

accounts for the solubility of ionic crystalline substance in water

A

Ion-dipole

38
Q

involved in the formation of the iodide complex – solubility of iodine in a solution of potassium iodide

A

Ion-induced dipole

39
Q

Electrovalent bond between two counter ions: a cation on one compound will interact with an anion on another compound = intermolecular
association

A

ION-ION INTERACTIONS

40
Q

interaction b/n a molecule containing a strongly electronegative atom such as O, N, and F.

A

HYDROGEN BOND

41
Q

Accounts for water’s high dielectric constant,
low vapor pressure and high boiling point

A

HYDROGEN BOND

42
Q

H bond exists between alcohol, carboxylic acids, aldehydes, esters molecules

A

HYDROGEN BOND

43
Q

Weakest Bond

A

HYDROGEN BOND

Physical Pharmacy (3 decks)

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