Introduction to Laminitis Flashcards
what are the 4 stages of laminitis
- developmental phase: inciting cause, presence of foot pain, we often miss
- acute phase: within 72 hours of onset of clinical signs, no P3 displacement
- subacute phase: greater than 72 hour duration; no P3 displacement
- chronic phase: P3 displacement
what are the 4 predisposing/triggering factors of laminitis?
- dietary: excessive ingestion of non-structural carbohydrates leads to large amounts of starch in hindgut and lactic acid production, causes hindgut bacteria death and toxin release/absorption and endotoxemia/SIRS
- inflam/infectious/toxic
-GI: enteritis, colitis
-non GI: pneumonia/pleuropneumonia, septic metritis, septicemia - endocrine dysfunction: most common cause currently!
-hyperinsulinemia/insulin resistance: equine metabolic syndrome. pituitary pars media dysfunction - mechanical/support limb: excessive weight bearing, lack of perfusion/ischemia
describe the 2 classifications of laminitis
- rotational: P3 shifted towards ground, due to compromised lamina allowing stronger pull of DDFT to override pull of CDE
- distal displacement: whole bone column displaces
-symmetrical: whole column sinks closer to ground together; look at how much of P2 sitting within hoof capsule versus normal
-asymmetrical: one side versus the other; medial sinks alone or lateral sinks alone
describe laminitis diagnostics (5)
- clinical signs: vary with stage/severity and number of feet affected
- acute phase: increased hoof wall temperature, increased intensity of digital pulses, hoof tester response (like abscess, variable)
- chronic stage: hoof capsule changes; ski slope, stretching of white line area on bottom of foot
- diagnostic imaging:
-radiographs: standard, lateromedial view, dorsopalmar/dorsoplantar views will give a good idea of what going on with hoof capsule for laminitis bases
-use the foramen that run through P3 as landmarks to draw a line through to the ground and joint distance between medial and lateral aspect of coffin joint - can do a venogram; backfill venous blood flow to get an idea of what going on with blood supply
describe endocrine testing for laminitis
need to get endocrine under control or won’t win battle with feet
1. measure ACTH: if increased indicates PPID/cushing’s; usually older horses
- insulin and leptin: check for equine metabolic syndrome; usually fatter younger horses
describe treatment and management of acute laminitis goals
treatment goals:
1. individualized treatment plan
2. identify predisposing factors
3. treat/eliminate these factors
overarching goals:
1. prevent further lamellae damage
2. maintain/improve blood supply to dermis of hoof
3. prevent P3 displacement
4. reduce pain and inflammation
describe 5 treatment modalities for acute laminitis
- cryotherapy:
-interrupt inflammatory signaling pathways and increase expression of anti-inflammatory IL-10
-initially vasoconstriction, but overall vasodilatory affect, decreases cellular metabolism when used long term (ice on constantly for 48-72 hours)
-numbs feet so horse is more comfy - appropriate confinement:
-stall size: enough room?
-stall bedding: hella important!! soft and thick; not sand (pressure sores) - systemic pharmocologic therapy:
-on farm: NSAIDs, acetaminophen
-hospital: opioids, systemic lidocaine, ketamine - surgical treatment:
-DDF tenotomy: remove pulling force all together; for unathletic horses; midmetacarpal approach or pastern approach - farriery: primary goal is to improve comfort, do literally whatever works
-for lamellar pain: alter load bearing, redistribute forces, decrease DDFT tension
-for solar pain: reduce/eliminate pressure under sensitive areas (wood clogs!)