Introduction to Exotic Medicine Flashcards

1
Q

What are the mandatory regulations of the care and used of laboratory animals?

A
  • The Animal Welfare Act (AWA)
    • The key law governing research with animals in the US along with exubitions
  • The Public Health Service Policy on Humane Care and Use of Laboratory Animals
  • The Good Laboratory Practice Act
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2
Q

The AWA. What is it and what was its purpose?

A
  • The animal welfare act
  • Was the first law that protected non-farm, non-wildlife, animals in the United States
  • ONLY federal law in the United States that regulates the treatment of animals in research and exhibition
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3
Q

Which groups enforce and regulate the AWA?

A

The USDA (United States Department of Agriculture), APHIS (Animal Plant and Health Inspection Service) and the Animal Care Agency

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4
Q

Can the USDA and APHIS perform unannounced visits and if so, how often?

A

Yes, at least once a year.

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5
Q

Businesses and individuals using regulated animals must be licensed or registered with the USDA and facilities with regulated animals must be inspected yearly by APHIS. True or False?

A

True.

  • Regulations include humane handling, care, identification, record keeping, treatment, and transportation.
  • These regulations apply to: Animal research facilities, animal dealers, animal exhibitors, operators of animal auction sales, carriers and intermediate handlers of animals in shipment.
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6
Q

Research facilities were NOT required by the AWA to have an attending veterinarian who shall provide adequate veterinary care. True or False?

A

False. All research facilities are required by the AWA to have an accredited veterinarian on board.

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7
Q

The AWA requires that at registered-facilities all proposals to use animals in research must be reviewed and approved by whom?

A

A committee whose membership includes, at a minimum, an experienced scientist, a veterinarian, and an individual who is not affiliated with the institution (kind of the whistle blower) (such as a local veterinarian, minister, or employee of the local Society for the Prevention of Cruelty for Animals: IACUC).

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8
Q

What is the Exotic Animal Definition?

A

Any animal that is not a dog, cat, horse or cow.

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9
Q

IACUC: what it stands for and what their responsibilities are.

A

Institutional Animal Care and Use Committee. Their responsibilities include:

  • Reviewing the facility’s animal care and use program
  • Inspecting the animal labs at least twice a year
  • Reviewing and approving, disapproving, or requiring modifications to research protocols
  • Responding to and, if necessary, investigating and acting on any public complaints or facility personnel reports of noncompliance involving animal care and use
  • Reporting deficiencies in animal care and use
  • Submitting evaluation reports to the institution
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10
Q

GLP

A

Good Laboratory Practice Act.

- Tighten the standards for research facilities that are engaged in product testing for the FDA

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11
Q

Order Rodentia (main and fun facts of rodents)

A
  • Upper and lower incisors grow throughout lives (open rooted)
  • 40% of all mammal species are rodents
  • Nocturnal or crepuscular
  • Highly successful and adaptive
  • Found in nearly every region and habitat
  • Generalist diet
  • High reproductive rate
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12
Q

What are the uses for mice and rats?

A

Feeders:
-reptiles, birds of prey
Research: (95% of all lab animals mice more than rats)
-helping in research for cancer, the human genome, beauty products, disease studies, etc.
Pets

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13
Q

Types of Mice and Rats

A

Mice: (Mus musculus)
- Fancy, Himalayan, Satin, Long-haired, Brindle, Seal Point
Rats: (Rattus norvegicus)
- Hooded, Siamese, Blue, Silver, Rex, Hairless, Dumbo
Exotics:
- Giant Gambian Rats, African Zebra Mice
- African Spiny Mice (illegal in many states), more social than domestic mice, calmer, less likely to bite.

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14
Q

Rat Behavior (Characteristics)

A
  • Considered to be better pets than mice (both are nocturnal)
  • Easily socialized
  • Rarely bite
  • Social animals in small groups (can also be housed alone), rats of both sexes can both be housed together
  • Males are more docile than females (rarely fight or territorial)
  • Neutered Males produce little odor
  • Curious and Intelligent (can be easily trained)
  • Good parents
    • do NOT cannibalize their young
    • Male rats care for young when females leave the nest
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15
Q

Mice Behavior (Characteristics)

A
  • More quick and active
  • Quicker to bite
  • Stronger odor
  • Social (should NEVER be housed alone), will often fight or kill other mice (males only), dominance hierarchy usually is established
  • Territorial
  • Males should NEVER be housed together
  • Parents WILL cannibalize young
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16
Q

General Anatomy of Mice and Rats

A

Teeth:
- Incisors are open rooted (iron pigments color the teeth orange)
- Cheek teeth (molars) do NOT continue to grow
- Separated by a gap called diastema
Eyes:
- Black (except for albinos which are red)
-Albinos have poor vision (rely on other senses)
- Poorly-formed 3rd eyelid (nictating membrane) gives eye buldging appearance
Tail:
- Theromoregulation
- Balance
- Sensitive to pain (never hold or restrain by the tail)

17
Q

Anatomy of the Digestive System of Mice and Rats

A
  • Monogastric: Stomach is divided into a non-glandular forestomach and a glandular hindstomach
  • Coprophagy (essential for vitamin absorption)
    • Allows for assimilation of B vitamins and other nutrients
    • Maintain proper gut flora
  • Unable to vomit (No fasting necessary for anesthesia)
    • They lack the esophageal musculature to do so
    • Powerful barrier between the esophagus and stomach
  • No Gall Bladder
  • Highly-developed cecum in rats
18
Q

Anatomy of the glands found within Mice and Rats

A
  • Harderian glands
    • Located behind each eye
    • Important for ocular lubrication and pheromone behavior
    • When stressed, will hypersecrete porphyrin red pigment (looks like crusty red tears) - Chromodacryorrhea
    • When grooming, will often transfer pigment to other parts of body (feet)
  • Zymbal’s Gland
    • Surround base of ear - modified sebaceous glands - secrete into the auditory canal
    • Tumors can look like ear infection - may become large
  • Few Sweat Glands
    • Only found around footpad
    • Tail and ears help with thermoregulation
  • No scent glands (use feces, urine, milk, skin phermones)
  • Acute sense of smell and hearing
  • Poor vision - use whiskers to navigate environment
19
Q

Physiology and Reproduction of Mice and Rats

A
  • Life span
    • Mice: 1-3 years
    • Rats: 2-4 years
  • Sexual Maturity
    • Both: 6-8 weeks (once mature, females will cycle every 4-5 days)
  • Gestation
    • Mice: 19-21 days
    • Rats: 21-23 days
  • Litter Size
    • Mice: 8-12 pups
    • Rats: Up to 18 pups
  • Weaned at 21 to 28 days
  • Altricial young (hairless/featherless needing nourishment from mom)
    • Hair by 7-10 days
    • Eyes open by 14-20 days
20
Q

Reproduction of Mice and Rats

A
  • Polyestrous
  • Can sex by comparing anogenital distance (greater in males)
  • Males have an os penis
21
Q

Define and explain Postpartum Estrus

A
  • Estrus with ovulation and corpus luteum production that occurs in some animals (the fur seal) immediately following parturition.
  • Lasts up to 24 hrs
  • Females bred at the postpartum estrus have an extended gestation period:
    • Facultative diapause (delayed implantation)
22
Q

Define and explain the Whitten Effect

A
  • A small group of anestrus females come into estrus when a male is introduced to the group causing a synchronization of cycles within 72 hours
  • Seen mostly in Mice
23
Q

Define and explain what the Bruce Effect is

A

*Pregnant females (bred within the past 24 hrs to 4 days) are exposed to the pheromones (urine/physical presence) of a strange male and abort.

24
Q

What are the 4 popular species of Hamster?

A
  • Golden (Syrian, now come in many color variations and hair length)
  • Russian (2 spp, illegal in some states)
  • Chinese and Dwarf (smallest)
  • Status in the wild is unknown