Introduction to Bioinformatics Flashcards
What is the brief definition of bioinformatics?
Biology + Information technology
Bioinformatics allow for the ______________, ______________, ______________, and ______________ of data using software tools
Storage, retrieval, analysis, and interpretation
Bioinformatics was first coiled in the 1960s as?
The study of information process in biotic systems
Bioinformatics is a developed program that is designed to determine the ______________.
Primary protein structures
______________ were represented in three-letter abbreviations.
Amino acid sequences
What were the main events during the 1970s?
- DNA sequences began to accumulate slowly in literature
- Translating sequence genes
- Sanger sequencing
What is Sanger sequencing?
Chain termination sequencing
What were the main events during the 1980s?
- Establishment of the GenBank
- Management and analysis
What are the three components of bioinformatics?
- DNA
- Database
- Database mining (bioinformatics tools)
What type of data are included in bioinformatics?
- DNA sequences
- Protein sequences
- Protein structures
What are the two types of database?
Primary and secondary
This type of database contains original and unprocessed biological data.
Primary database
Primary databases are used as a reference for ______________ and ______________.
Genome analysis; comparison
Primary databases are used as a reference for ______________ and ______________.
Genome analysis; comparison
______________ is analyzed to understand differently expressed genes and understand gene expression.
Transcriptomic data
This type of primary database includes information about genes and proteins.
GenBank
What does EMBL stand for?
European Molecular Biology Laboratory
What are the main objectives of EMBL?
- Storage and distribution of nucleotide and protein sequences
- Provide tools and researches for researchers for analyzing data
- Generation of phylogenetic trees
- Bioinformatics analysis
- Data mining tools
What does DDBJ stand for?
DNA Data Bank of Japan
What are the main objectives of DDBJ?
- Collecting and exchanging nucleotide sequence data
- Managing bioinformatics tools for data submission and retrieval
- Organizing bioinformatics courses in Japanese to teach people how to analyze data
- Retrieval and analysis of sequences
- Statistical analysis
- Data mining tools
This type of database contains information that has already been processed and curated.
Secondary Database
What are the three bioinformatics tools?
- Sequence analysis
- Structural analysis
- Functional analysis
The database mining and bioinformatics tools are categorized based on __________, __________, and __________.
Functionality; purpose; complexity
This is used to analyze nucleotide/protein sequences and identify homologous sequences.
Sequence Analysis
This helps understand evolutionary relationships between organisms.
Sequence Analysis
This is essential for understanding functions and relationships between different genes and proteins.
Functional Analysis
This helps identify key pathways involved in certain diseases.
Functional Analysis
