Introduction -History Flashcards
First patient to be blood transfused.
Reason for death of that person and the 3 human donor.
Pope Innocent VII
Incompatibility
It was the first principal obstacle to overcome in blood transfusion.
Clotting
Give the problems encountered in blood transfusion in the history.
CIMA -DOD Clotting Incompatibility Methods and devices Availability and preservatives Disease transmission Other transfusion rxns Circulatory overload
Give the 1st experiment conducted in blood transfusion.
Animal-animal
Animal-human
Use of non-blood
Year of first blood transfusion.
1492
First documented successful transfusion of human blood to a patient.
What was the disease of the patient.
James Blundell
Postpartum hemorrhage - hypovolemic shock (bleeding - low blood volume ; mother gave birth)
How many years have Blundell performed this transfusion?
How many became successful?
5 years (1825-1830)
5/10
First anticoagulant to be discovered.
What were the disadvantages?
Sodium phosphate (Na3PO4)
- toxic level was not determined
- very short shelf life
Person who recommended sodium phosphate as an anticoagulant.
What year?
Braxton Hicks
1869
Discovered NSS.
What is NSS?
George Hayem
Normal Saline Solution
Discovered ABO blood groups and blood typing.
Karl Landsteiner (1901)
Designed the first device in performing transfusions.
Edward E. Lindemann (vein to vein transfusion of blood)
What was the invention of Lindemann?
Multiple syringes and special cannula
Disadvantages of the invention of Lindemann.
Time-consuming and complicated
Designed the syringe-valve apparatus.
How does this device works?
Unger
Transfusion from donor to patient by an unassisted physician
Anastomosis
Alexis Carell
Proposed the use of Sodium Citrate as Ac
Hustin (1914)
Determined the minimum amount of citrate needed for anticoagulation.
Lewisohn
He demonstrated the nontoxicity in small amounts of citrate.
Lewisohn
Proposed the use of AHG using Coombs.
Transcribe AHG.
Moreschi
Anti-human globulin
Use of AHG.
Potenciator/ potenciating medium
- enhance Ag-Ab rxn
Introduced a citrate-dextrose solution for blood preservation.
Rous and Turner (1916)
First director of the blood preservation during world war II.
Charles Drew
In 1943, ____ and ____ of England introduced the formula for the preservative ACD.
TRANSCRIBE ACD.
Loutit and Mollison
Acid-citrate Dextrose
