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PHYSIOLOGY ENDOCRINE > introduction endocrine > Flashcards

introduction endocrine Flashcards

1
Q

steroid hormones are

A
  • slow
  • long half life
  • protein bound
  • needs time
  • cannot be urinated off
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2
Q

peptide hormones are

A
  • fast
  • short half life not protein bound (free unbound)
  • not protein bound goes to the kidney and urinated off
  • effects are instantly and gone
  • water soluble
  • outer surface of the cell membrane
  • stored in the vesicles but not released constantly
  • dissolved in plasma
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3
Q

steroid hormones (like cholesterol)

A
  • thyroid hormone
  • progesterone
  • no cell surface receptor
  • effects/target is to the nucleus not at the cell surface
  • lipid soluble hormones(protein bound) long half life
  • inside the cell into the nucleus
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4
Q

steroid hormones

A
  • goes to second messenger to make new proteins
  • mRNA
  • protein synthesis
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5
Q

peptide hormones

A
  • activates protein that is already made
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6
Q

not protein bound

A
  • DHEA adrenal androgen

- water soluble due to its sulfated

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7
Q

all steroid hormones are

A
  • protein bound except

- DHEA (sulfated)

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8
Q

cell surface receptor vs G protein

A
  • peptide hormone attaches to the receptor
  • receptor activates G protein
  • G protein cause the effect inside the cell (second messenger)
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9
Q

second messengers (phosphorylating)

A
  • cAMP
  • Ca 2+
  • IP3 phosphorylating
  • DAG
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10
Q

all hormones are

A
  • made in a pulsatile nature(action) except

- THYROID (THYROXINE) which is made constant, released all the time

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11
Q

insulin

A
  • does not effectively use cAMP

- it has TYROSINE KINASE as a receptor mechanism

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12
Q

all peptide hormones are/ have

A
  • short half life not protein bound (free unbound) except
  • IGF (insulin like growth factor) which is a protein carrier/bound
  • to measure acromegaly and gigantism
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13
Q

lowers the binding globulins

A
  • LIVER DISEASE
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14
Q

case:
what organ disease is associated with low total steroid hormone level
case:
long standing DIABETES and HYPERTENSION (most common cause of nephrotic syndrome) which of the ff blood levels are down due to it

A
  • KIDNEY DISEASE
  • nephrotic syndrome all steroid hormone is excreted due to the hole in the kidney to loose the hormones
  • STEROID HORMONE
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15
Q

peptide hormones (urinated) washed out

A
  • FSH
  • LH
  • GROWTH HORMONE
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16
Q

only free hormone has a

A
  • target organ effect
  • feedback inhibition
  • regulated
17
Q

case:

in PREGNANCY which hormone goes up

A
  • total T4
  • testosterone and androgen decrease binding globulin
  • female sex hormones increase binding globulins (ESTROGENS)
  • free T4 constant
18
Q

case:

liver disease

A
  • decrease binding globulins

PHYSIOLOGY ENDOCRINE (3 decks)

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