Introduction Flashcards

1
Q

What determines disease burden rankings?

A
mortality
morbidity (YLDs = years lived with disability, hospital admissions, GP consultation rates, time of school or work)
data may not extrapolate from one country to another
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Statistics of respiratory disease in England?

A

affects 1/5 people
3rd biggest cause of death
hospital admissions risen at 3x rate of normal admissions (people admitted due to other diseases treated better, few admitted)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What can particularly affect lung disease?

A

winter pressures - respiratory disease admissions spike during winter
picks up in Sep for those with exacerbations of asthma, Jan/Feb rise of COPD/pneumonia related issues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the trouble with diagnosis of lung disease?

A

1/3 people with first admission not previously diagnosed

we are bad at diagnosing lung disease (spirometry)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is bad about minimal spirometry testing?

A

small% of those with disease are actually diagnosed - few receive necessary treatment

over look burden of disease
money wasted

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Respiratory mortality trends in males and females in EU?

A

Deaths higher in females than males

UK has much higher rates than rest of EU

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Most common lung diseases?

A
asthma
COPD
bronchiectasis 
obstructive sleep apnoea 
sarcoidosis 
lung cancer 
IPF
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Highest mortality rate?

A
lung cancer
COPD 
pneumonia
IPF
asthma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Statistics of lung cancer?

A

largest cause of cancer death in UK, high prevalence, fatal (very poor 5 year survival)
kills more women in UK than breast cancer

less than 5% survive more than 10 years
86% preventable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Are things improving? Why?

A
1 to 2 year survival rates are improving 
prompt diagnosis 
better therapy
tobacco control
smoking less prevalent
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Main categories of lung disease?

A

Infection
Pulmonary vascular disorder
Airway obstruction (localised/generalised)
Small lung disorder/restrictive disorders (within or outside lung)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the current ongoing epidemic?

A

mesothelioma

asbestos related malignancy of the lining of the lung

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the significance of pulmonary emboli?

A

clots in the lung may complicate immobility and be fatal due to obstruction of pulmonary artery that reduces heart ability to deliver deoxygenated blood to gas exchange surfaces in the lung - no/reduced gas exchange
largest cause of maternal death associated with childbirth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the significance of obesity?

A

increases respiratory workload and respiratory dysfunction
associated with increased risk of asthma and sleep related breathing disorders
breathlessness by restricting size of lung
causes asthma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

35% increase in diagnosis of…

A

idiopathic pulmonary fibrosis

median survival only 3 years from diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Significance of obstructive sleep apnoea?

A

6x normal risk of road traffic crash

17
Q

Important common symptom of lung disease?

A

breathlessness (dyspnoea) - difficult/laboured breathing

18
Q

What can breathlessness point to?

A

lung disease
heart disease
pulmonary vascular disease
neuromuscular disease (diaphragm weakness)
systemic disorder (anaemia, hyperthyroidism, obesity)

19
Q

Oxygen requirement of adults?

A

250ml/min

20
Q

How does COPD interfere with normal lung function?

A

smoking/pollution damages respiratory mucosa - cilia less able to remove phlegm
excess mucous obstructs airways
mucous gland hyperplasia (glands enlarge more than 40% of cartilaginous airway wall - cannot expand)
radial traction effect of surrounding elastic lung tissue maintains normal airway patency - in COPD not elastic surrounding lung tissue
distorted alveoli

21
Q

How does pneumonia affect lungs?

A

alveoli filled with neutrophils, inflammatory cells and bacteria
air sacs cannot take part in gas exchange

22
Q

How does asbestos affect lung function?

A

causes lung fibrosis that distorts and destroys alveoli where gas exchange takes place