Introduction Flashcards
Role and function of human bones
- Provides mechanical support
- Produces red blood cells
- Protects internal organs
- Provides rigid mechanical links and muscle attachment sites
- Facilitates muscle action and body movement
- Serves as active ion reservoir for calcium and phosphorus
Composition and Structure of Bone
- Inorganic Components (e.g., calcium and phosphate) 65-70% Dry Weight
- Organic Components (e.g. Collagen) 25-30%Dry Weight
- Water (25-30%)
- protein matrix (mainly collagen) upon which calcium salts (especially phosphate) are deposited (25-30% of dry weight)
- bone salts ≈ 65-70% of dry weight
- osteocollagenous fibers determine strength and resilience
- osteon (haversian system) - basic structural unit of bone
Bone remodeling process
*Continues
Bone remodeling also help maintain mineral homeostasis by transferring calcium and other ions into and out of bone.
Osteoclasts and osteoblasts are the major cell types involved in bone remodeling.
Osteoclasts erode bone matrix whereas osteoblasts secrete it.
The epiphyses, or epiphyseal plates, are growth centers where new bone cells are produced until the epiphysis closes during late adolescence or early adulthood.
The inner layer of the periosteum, a double-layered mem-brane covering bone, builds concentric layers of new bone on top of existing ones specialized cells called os-teoblasts build new bone tissue and osteoclasts resorb bone tissue.
Biomechanical Characteristics of Bone
- Physical Activity
- Lack of Activity
- Gravity
- Hormones
- Age & Osteoprosis
- Bone Deposits (myositis Ossificans)
Bone Response to Stress
- bones respond to certain kinds of training by hypertrophying
- Wolff’s law, the densities, and to a lesser extent, the sizes and shapes of bones are de-termined by the magnitude and direction of the acting forces
- Increased or decreased mechanical stress leads to a predominance of osteoblast or osteoclast activity, respectively.
- osteoporosis –increase porosity of bone, decrease in density and strength, increase in vulnerability to fractures
- piezoelectric effect – electric potential created when collagen fibers in bone slip relative to one another, facilitates bone growth
- use of electric and magnetic stimulation to facilitate bone healing
• shape of bone reflects its function
o tennis arm of pro tennis players have cortical thicknesses 35% greater
than contralateral arm (Keller & Spengler, 1989)
Types of Bone
- axial skeleton
- appendicular skeleton
- Long Bones
- Short Bones
- Flat Bones
- Irregular Bones
- Sesamoid Bones
axial skeleton
skull, thorax, pelvis, & vertebral column
appendicular skeleton
upper and lower extremities
condyle
- a rounded process of a bone that articulates with another bone
- e.g. femoral condyle
epicondyle
- a small condyle
* e.g. humeral epicondyle
facet
- a small, fairly flat, smooth surface of a bone, generally an articular surface
- e.g. vertebral facets
foramen
- a hole in a bone through which nerves or vessels pass
* e.g. vertebral foramen
fossa
- a shallow dish-shaped sec-tion of a bone that provides space for an articulation with another bone or serves as a muscle attachment
- glenoid fossa
process
- a bony prominence
* olecranon process
tuberosity
- a raised section of bone to which a ligament, tendon, or muscle attaches; usually created or enlarged by the stress of the muscle’s pull on that bone during growth
- radial tuberosity
Long Bone Structure
- cortical or compact bone
- (porosity ~ 15%)
- periosteum: outer cortical membrane
- endosteum: inner cortical membrane
Mechanical Loading of Bone
• elasticity: ability to return to normal state after stretch
elastic limit: stretch beyond this limit will cause permanent damage
• plasticity: stretched too far such that does not return to its normal state
Stress-Strain Relationships
- Elastic modulus – slope of the stress-strain curve in the elastic region (measure of stiffness)
- Plastic modulus – slope of the stress-strain curve in the plastic region
- Area under stress strain curve is measure of energy absorbed