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Pharmacology > Introduction > Flashcards

Introduction Flashcards

1
Q

What are pharmacodynamics

A

What a drug does to the body (bio effects an mechanism of action)

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2
Q

What are pharmacokinetics

A

What the body does to the drug (abs, dist, metab, excretion)

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3
Q

What is a drug

A

Any synthetic or natural sub which used in treatment, prevention or diagnosis of disease
( caffeine, illicit subs such as heroin, food additives)

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4
Q

How do drugs acts

A

Drugs act by binding to tragedy molecules selectivity

Bind to reg protein

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5
Q

What are some drug targets

A 
Enzymes 
Carrier molecules
Ion channels 
Receptors 
Rna 
DNA
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6
Q

What are receptors

A

Macromolecules that mediate the bio actions of hormones and neurotransmitters - endogenous subs

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7
Q

What are the two types of drugs

A

Agonists or antagonists

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8
Q

What is an agonists

A

Drug that binds to a receptor to produce a cellular response

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9
Q

What is an antagonist

A

Drug that blocks the actions of an agonist

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10
Q

What do agonists possess

A

Affinity and efficacy bind to receptors to activate them

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11
Q

What is affinity

A

Strength of association between ligand and recep

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12
Q

What is efficacy

A

Ability of an agonist to evoke a cellular response

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13
Q

What do antagonists do inaction

A

Bind to receptors but do not activate them
Possess affinity but lack efficacy
Block receptor activation by agonists

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14
Q

What sit he relationship between conc/dose and response

A

Hyperbolic or sigmoidal

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15
Q

What sit he conc of agonist which elicits a half maximal response

A

EC50

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16
Q

What is competitive antagonism

A

Binding of agonist and antagonist occur at same time - orthosteric site and is thus competitive and mutually exclusive

17
Q

What is non comp antagonism

A

Agonist binds to orthosteric site and antagonist binds to sep allosteric site and is not competitive
Both may occupy receptor simultaneously
Activation cannot occur when antagonist is bound

18
Q

What does an agonist along show

A

High potency and efficacy

19
Q

What does an antagonist alone show

A

Lower potency but high efficacy

20
Q

What does an agonist and non comp antagonist show

A

Potency and efficacy dec

21
Q

What is pharmacology

A

Study of drugs what they are and what they do

Study manner which drugs affect living tissues and organs modified by chem substances

Pharmacology (4 decks)

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