Introduction Flashcards
References to the study of urine can be found in the_________and in__________
/drawings of cavemen
/Egyptian hieroglyphics
5th century BC wrote a book on “uroscopy.”
Hippocrates
Era were color charts had been developed that described the significance of 20 different colors and testing of glucose through ant testing and taste testing
1140D
1694: discovery of albuminuria
Frederik Dekker’s
Book inspired the passing of medical licensure laws in England
Book of Pisse Prophet
1627: Book of Pisse Prophet by
Thomas Bryant
Invention of microscope
17th century
Urine sediment
Thomas Addis
Concept of Urinalysis
1827: Richard Bright
On what year routine examination of urinalysis began to disappear
1930s due to development of modern testing techniques
Organ with a noninvasive means by which to directly evaluate its status
KIDNEY
Urine is an ___________ of plasma
ULTRAFILTRATE
Reasons for performing urinalysis:
- aiding in the diagnosis of disease
- screening asymptomatic populations for undetected disorders
- monitoring the progress of disease
- effectiveness of therapy
Kidney converts approximately___________of filtered plasma to the average daily urine output of_______
170,000 mL
1200 mL
Urinary system composed of 4 main components:
KIDNEY
URETERS
URINARY BLADDER
URETHRA
where urine is formed by FILTRATION of blood
KIDNEY
carry the urine to the bladder
URETERS
stores the urine produced
BLADDER
delivers the urine for EXCRETION
URETHRA
Responsible for removal of waste products
& reabsorption
Cortical nephron
function for concentration of urine
Juxtamedullary nephron
functional unit of the kidney
Nephron
Nephron
1 to 1.5 million each kidney
Cortical nephron
85%
Juxtamedullary nephron
15%
Outer layer of kidney located below the RENAL CAPSULE
Cortex
Innermost part of kidney that is split up into number of sections called
Medulla
Renal pyramids
Funnel like dilated part of ureter in the kidney
Renal pelvis
consists of a coil of approximately 8 capillary lobes (capillary tuft)
Glomerulus or Renal Corpuscle
surround the proximal and distal convoluted tubules
Peritubular capillaries
located adjacent to the ascending and descending loop of Henle
Vasa recta
Organic Components
Urea
Creatinine
Uric acid
Hippuric acid
Carbohydrates
Pigments
Fatty acids
Enzymes
Major organic component: product of protein and amino acid metabolism
Urea
Product of creatine metabolism by muscles
Creatinine
common component in kidney stones; derived from catabolism of nucleic acid in food
Uric acid
Benzoic acid is eliminated in this form, increases with high vegetable diet.
Hippuric Acid
Inorganic Components
• Chloride
• Sodium
• Potassium
• Sulfate
• Phosphate
• Ammonium
• Calcium
Primary inorganic component. Found in combination with sodium (table salt) and many other inorganic substances
CHLORIDE
Salt
Sodium
Combined with chloride and other salts
Potassium
Derived from amino acids
Sulfate
Combines with sodium to buffer the blood
PHOSPHATE
Regulates blood and tissue fluid acidity
AMMONIUM
Combines with chloride, sulfate, and phosphate
CALCIUM
Normal daily urine output
1200 to 1500ml
600 to 2000ml
Decrease in urine output
OLIGURIA
Oliguria for infants
<1 ml/kg/hr
Oliguria for children
<0.5 ml/kg/hr
Oliguria for adults
<400 ml/day
Urine cessation
ANURIA
Increase urine output at night
NOCTURIA
Increase daily urine output
POLYURIA
Polyuria seen on ADULTS
> 2.5 L/day
Polyuria seen on CHILDREN
> 2.5 to 3 mL/kg/day
Diabetes Mellitus Polyuria SG
1.030 or above
Exceed renal threshold for glucose
Diabetes Mellitus Polyuria
Diabetes Insipidus Polyuria SG
1.005
Decrease Antidiuretic Hormone production
Diabetes Insipidus Polyuria
Urine specimen for glucose monitoring
FASTING SPX or SECOND MORNING SPX
Urine specimen is tested for presence of KETONES & GLUCOSE
GLUCOSE TOLERANCE SPECIMEN
Urine specimen for URINE QUANTITATIVE ASSAY
24 HOUR (TIMED) SPX
24 HOUR (TIMED) SPX
/Catecholamines
/17-hydroxysteroids
/Electrolytes
Urine specimen for bacterial culture
CATHETERIZED SPECIMEN
Urine specimen for CYTOLOGIC EXAMINATION
Suprapubic Aspiration Specimen
Less traumatic method for obtaining urine for bacterial culture and routine urinalysis
Midstream Clean catch Specimen
Also known as 3 glass collection
Prostatitis Specimen
1st container for Prostatitis Specimen
URETHRAL INFECTION; First passed urine
2nd container for Prostatitis Specimen
URINARY BLADDER INFECTION; Midstream portion of urine
3rd container for Prostatitis Specimen
Urine with prostatic fluid
4th container for Prostatitis Specimen
Post prostatic massage urine or STAMEY MEARS
3rd and 4th container
PROSTATIC INFECTION
Drug Spx Collection
Required amount: 30 to 45 ml
Temperature: 32.5 to. 37.7°C
Check for every 4 minutes
No tampering
Spx handled securely
Proper Identification