Introduction Flashcards
1
Q
what pH area are most drugs
A
weak acid or weak bases
2
Q
where is aspirin mostly absorbed, why
A
stomach because eqm pushed towards lipid soluble form (r-COOH), can cross membrane then dissociates and gets trapped in the plasma
3
Q
what happens to aspirin once into blood stream
A
pH is 7.35-7.45 so acid dissociates and can’t get back across gastric mucosa
4
Q
Which drugs are zero order, what does it mean
A
aspirin, ethanol, phenytoin 2x half life=full elimination
5
Q
which drugs are 1st order and what does it mean
A
all the rest, the concentration in the body halves every half-life time period
