Intro to Serology-Immunology

Question 1

Resistance to disease (infectious disease)

Answer 1

Immunology

Question 2

Branch of biology that studies immune systems in all organisms

Answer 2

Immunology

Question 3

Study of molecules, organs, systems responsible for the recognition & disposal of foreign material

Answer 3

Immunology

Question 4

How body components respond and interacts

Answer 4

Immunology

Question 5

Desirable & undesirable consequences of immune interactions

Answer 5

Immunology

Question 6

Ways in which the immune system can be advantageously manipulated to protect against or treat disease

Answer 6

Immunology

Question 7

Scientific study of serum and other body fluids

Answer 7

Serology

Question 8

430 BC

Recorded that individuals who had previously contracted plague recovered

Answer 8

Thucydides

Question 9

430 BC

Recognized the “immune” status of those individuals

Answer 9

Thucydides

Question 10

1000 AD

Practiced a form of immunization by inhaling dried powders derived from smallpox lesions

Answer 10

The Chinese - “Variolation”

Question 11

1798

Smallpox vaccination

Answer 11

Jenner

Question 12

1862 Phagocytosis

Answer 12

Haeckel

Question 13

1862

Father of Immunology
○ Live attenuated, chicken cholera, anthrax vaccine

Answer 13

Louis Pasteur

Question 14

1885

Therapeutic Vaccination
○ First report of live “attenuated” vaccine for
rabies

Answer 14

Louis Pasteur

Question 15

1883-1905

Cellular Theory of Immunity through phagocytosis

Answer 15

Metchnikoff

Question 15

1890

Proposed the Humoral Theory of Immunity

Answer 15

Von Behring & Kitasato

Question 15

1891

Demonstration of cutaneous (delayed type) hypersensitivity

Answer 15

Koch

Question 16

1900

Antibody Formation Theory

Answer 16

Ehrlich

Question 17

1902

Immediate-Hypersensitivity Anaphylaxis

Answer 17

Portier & Richet

Question 18

1903

Arthus Reaction of Intermediate Hypersensitivity

Answer 18

Nicolas Maurice Arthus

Question 19

1938

Hypothesis of Antigen-Antibody Binding

Answer 19

Marrack

Question 20

1944

Hypothesis of Allograft Rejection

Answer 20

Medawar

Question 21

1949

Development of Polio vaccine = OPV: weakened virus strain

Answer 21

Sabin

Question 22

1949

Development of Polio vaccine = IPV: killed virus strain

Answer 22

Salk

Question 23

1951

Vaccine against Yellow Fever

Answer 23

Reed

Question 24

1953

Graft-versus-Host Reaction

Answer 24

Dick W. van Bekkum

Question 25

1957

Clonal Selection Theory

Answer 25

Burnet

Question 26

1957

Interferon (viral interference)

Answer 26

Alick Isaacs & Jean Lindemann

Question 27

1958-1962

Human Leukocyte Antigen (HLAs)

Answer 27

Jean Dausset

Question 28

1964-1968

T-and B-cell cooperation in immune cooperation

Answer 28

Henry Claman

Question 29

1972

Identification of antibody molecule

Answer 29

Edelman & Porter

Question 30

1975

First monoclonal antibodies

Answer 30

Kohler & Milstein

Question 31

1985-1987

Identification of genes for T-cell receptor

Answer 31

James P. Allison

Question 32

1986

Monoclonal Hepatitis B vaccine

Answer 32

Pablo DT Valenzuela

Question 33

1986

Th1 versus Th2 Model of T helper cell function

Answer 33

Mossman

Question 34

1996-1998

Identification of Toll-like receptor

Answer 34

Jules Hoffman & Bruce Beutler

Question 35

2001

FOXP3 - Forkhead box P3, a transcription Factor
○ Gene directing regulatory T-cell development
○ Prevent autoimmune diseases

Answer 35

Ramsdell & Colleagues

Question 36

2005

Dev’t of Human Papilloma Virus (HPV) vaccine

Answer 36

Ian Frazer