Intro to Pulmonary A/P Pumonary Physiology Flashcards
Ventilation
mechanical movement of gases into and out of the lungs
Lung Volumes
Tidal Volume, Inspiratory Volume, Expiratory Reserve Volume, Residual Volume
TV
Tidal Volume
IRV
Inspiratory Reserve Volume
ERV
Expiratory Reserve Volume
RV
Residual Volume
Tidal Volume (TV)
normal amount of air inhaled/exhaled
Inspiratory Reserve Volume (IRV)
additional volume of air that can be inhaled beyond normal TV inhalation
Expiratory Reserve Volume (ERV)
additional volume of air that can be exhaled beyond tha normal TV exhalation
Residual Volume (RV)
volume that remains in the lungs after a forceful expiratory effort
Lung Capacities
Inspiratory Capacity, Functional Residual Capacit, Vital Capacity, Total Lung Capacity
IC
Inspiratory Capacity
FRC
Functional Residual Capacity
VC
Vital Capacity
TLC
Total Lung Capacity
Inspiratory Capacity (IC)
TV + IRV
max amount that can be inhaled
Functional Residual Capacity (FRC)
ERV + RV
amount of air remaining in the lungs after a normal TV exhalation
Vital Capacity (VC)
IRV + TV + ERV
max amount of air that can be exhaled following a max inhilation
Total Lung Capacity (TLC)
IRV + TV + ERV + RV
max volume which the lings can be expanded; sum of all pulmonary volumes
Hemodynamics of Pulmonary System
Respiratory Rate, Tidal Volume, Minute Ventilation
RR
Respiratory Rate
Vt
Tidal Volume
MV
Minute Vetilation
Respiratory Rate (RR)
normal adult respiratory rate is 12 to 29 breaths/minute
Tidal Volume (Vt)
volume of inspired air inhaled/exhaled (350-500 mL)
Minute Ventilation (MV)
normal adult minute ventilation is 4-6 L/min
hemodynamics of pumonary system equation
RR x Vt = MV
Neurons in parts of the brainstem, including ht emedular oblongata and pons, provvide controll for —
automatic breathing and asjust ventilatory rate and tidal volume for normal gas exchange
the medulla oblongata contains inspiratory neurons that produce inspiration and expiratory neurons that are triggered with —
forced expiration
inspiratory neurons are located in the —
inspiratory center, or dorsal respiratory group, of the medulla
enhanced frequency of firing of inspiratory neurons —
increases the motor units recruited and results in deeper breaths
an elongation in the time of firing of inspiratory neurons —
prolongs each breath and results in slower respiratory rate
a cessation of inspiratory neurons causes —
elastic recoil of the lungs and passive expiration
ANS control of the lungs
- stimulation of the vagus nerve
- stimulation of the sympathetic nerves
stimulation of the vagus nerve
- bronchial constriction
- dilation of pulmonary arterial muscle
- increased glandular secretion
stimulation of the sympathetic nerves
- bronchial relaxation
- constriction of pulmonary arterial muscle
- decreased glandular secretion
CNS control of breathing
medulla and pons
medulla inspiratory neurons in DRG
-enhanced firing leads to increased RR
-slowing firing leads to decreased RR
-cessation leads to elastic recoil and passive expiration
medulla expiratory neurons in VRG
neural stimulation causes inhibition of inspiratory system (DRG) to allow for deeper expiration if needed
medulla pre-botxinger complex
thought to be intrinsic rhythm generator like pacemaker in heart
pons pneumotaxic center
maintains rhythm of breathing, balancing time periods of inspiration and expiration by inhibiting apneustic center
pons apeustic center
facilitates sustained breathing when uninhibited by pneumotaxic center
afferent connections to brainstem function
respiratory centers receive afferent input from various locations
afferent connection to brainstem
hypothalamus
limbic system
chemoreceptors
lungs
limbic system/hypothalamus function
involved in the maintenance of basal ventilation, and modulation of respiration in hypoxic and hypercapnic conditions, during dynamic exercise, in awake and sleep states, and under pain or stress
limbic system/hypothalamus function examples
anger = breath holding
pain = tachypnea or gasping
anxiety = uncontrollable hyperventilation
chemoreceptors location
brainstem and peripheral arteries
chemoreceptors of brainstem
sense pH change in CSF -> if pH low, result in increased RR and depth of breathing
chemoreceptors of peripheral arteries
-communicate to respiratory centers via vagus/glossopharyngeal nerve.
-sense when CO2 levels in blood are high, and O2 levels are low -> result in increased RR and depth of breathing
Voluntary breathing
control originates from the primary motor cortex and sends signal to spinal cord, bypassing the respiratory centers
voluntary breathing examples
-playing wind instrument
-singing
-holding breath