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Pharmacology > Intro to PK/PD Past Quizzes > Flashcards

Intro to PK/PD Past Quizzes Flashcards

1
Q

N-acetylation of Hydralazine could lead to what disease?

A

systemic lupus erythematosus

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2
Q

banned COX-2 inhibitor drug - causing cardiovascular side effects

A

rofecoxib

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3
Q

paracetamol does not undergo this biotransformation process

A

acetylation

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4
Q

tyrosine kinase receptor of insulin is ___

location

A

extracellular

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5
Q

drug with the highest Vd (volume of distribution)

A

diazepam

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6
Q

anti-angiogenic drug ranibizumab: use is for what disease?

A

benign prostatic hyperplasia

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7
Q

naloxone & morphine exhibit what kind of antagonism?

A

physiologic

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8
Q

2nd messenger of G-coupled receptor

A

adenylyl cyclase

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9
Q

The serpentine receptor with 7 transmembrane segments and 3 intracellular loops

A

GPCR

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10
Q

The type of metabolism in liver

A

microsomal

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11
Q

The drug thalidomide is used to treat what disease

A

Multiple myeloma

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12
Q

What is the relationship between bioaccumulation and

excretion

A

inverse

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13
Q

If a drug has a half-life of 10 hours, what is its dosage

interval

A
  • Once a day (10 hr x 4 / 2 = 20 hr interval)
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14
Q

D/AUC : formula for ___

A
  • Clearance
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15
Q

Relapse happens when tamoxifen is used by Caucasian-Asians because they belong to what type of metabolizer

A
  • Poor
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16
Q

The effect of CYP enzyme inhibitor on drug therapeutic and side effects

A
  • Prolonged
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17
Q

Drug serum level measurement

A
  • Concentration
18
Q

What is used to treat methamphetamine poisoning

A
  • Ammonium chloride
19
Q

This is the maximal concentration of receptor sites in tissue

A
  • Bmax
20
Q

Therapeutic index is a measure of?

A
  • Safety
21
Q

What is the toxic metabolite of Paracetamol

a. capsaicin
b. mephenytoin
c. coumarin
d. N-acetyl-ρ-benzoquinone imine

A

D

22
Q 
Type of mobilizer in which there is an increase in effectivity of
omeprazole
a. Poor 
b. Ultra Rapid 
c. Extensive
d. Rapid
A

A

23
Q

Peak effect in serum before oscillating gradually to zero

a. Hahaha
b. AUC
c. SSC
d. Sorry

A

C

24
Q

If t ½ is 4 hrs, what is the dosing interval??

a. Once a day
b. Twice a day
c. Thrice a day
d. Blah

A

C

25
Q 
Simple nucleotide polymorphisms are important in this branch of
pharmacology.
a. Pharmacogenomics 
b. Pharmacoeconomics
c. Pharmacoepidemiology
 d. Posology
A

A

26
Q

Na+-channel blockade is the mechanism of action of this drug:

a. Red-tide poison
b. Anesthesia
c. I forgot the choices HAHAHA sorry
d. Mushroom poison

A

B

27
Q

Inactive compound readily absorbed and distributed in the body

a. Xenobiotic
b. O..(forgot huhu)
c. Prodrug
d. Lead compound

A

C

28
Q

Ach-Atropine type of antagonism

a. Chemical
b. Physiologic
c. Competitive
d. Noncompetitive

A

B

29
Q

Diminished response over seconds or minutes after reaching an
initial high level even in the continuous presence of an agonist
a. Desensitization
b. Stabilization
c. Something else
d. Anaphylaxis

A

A

30
Q

Propensity of drug combined to receptor is _______

a. Biosimilar
b. Different
c. Specific
d. blah

A

B

31
Q 
Rate of elimination/concentration
a. Vd 
b. CL 
c. t1/2
d.
A

B

32
Q 
Shortest half life
a. Lidocaine 
b. Hydralazine. 
c. Chloroquine
d.
A

B

33
Q

What is used to treat aspirin (ASA) poisoning?

a. NaHCO3
b. NH4Cl

A

a

34
Q

Most abundant (enzyme?) isoform in the liver

A
  • UGT-UDP
35
Q

Source of furanocoumarin?

A
  • Grapefruit juice
36
Q

Serpentine receptor that is ―7-transmembrane‖ in description

A
  • G protein coupled receptor
37
Q

Rofecoxib was banned recently. It belongs to what type of drug class?

A
  • Anti-inflammatory
38
Q

Clopidogrel belongs to what type of drug class?

A
  • Anti-platelet
39
Q

2nd messenger of G-coupled receptor

A
  • Inositol triphosphate
40
Q

Effects are flushing, nausea, vomiting

A
  • Ethanol

Pharmacology (1 decks)

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