Intro To pharmacology Flashcards
Controlled substances, schedules, or classifications
Determined by the drug enforcement agency (DEA) ,justice department, and then scheduled according to the controlled substance act.
How is a drug classified or scheduled?
Based on potential for abuse and physical, psychological dependence on the drug
Controlled substances required information
Name of patient receiving narcotic
Amount of narcotic used
The date and time the narcotic was given
The name of the physician prescribing the narcotic
Name of the nurse administering narcotic
A narcotic prepared and not used must be witnessed by another nurse, that it was destroyed
Documentation is done by both nurses in the narcotic record 
Requirements for narcotics in facilities
Kept in a locked cabinet or cart. Usually double locked.
Facility check on opioids at the beginning and ending of every shift and count whenever dispensing them by two nurses
Checked after administration of the opioid
Narcotics may be ordered routinely or PRN
What is pharmacology?
Exploration of substances that are used to heal and comfort the sick, and then other ways help us to live longer and healthier lives
Pharmacodynamics
Refers to the effects of drugs on the body or more scientifically the negative and positive bio chemical, or physiological changes that a drug creates
There are six categories of desired effects
Categories of medication
Curative
Prophylactic
Diagnostic
Palliative
Replacement
Destructive
Curative
treats, a problem
Examples are antibiotics or a diuretic
Prophylactic
Prevents a problem
Diagnostic
Helps diagnose a disease or condition
Examples are contrast dyes or barium enema
Palliative
Treat symptoms to make the patient more comfortable
Examples are pain, meds or inhalers
Destructive
Destroys, tumors, and or microbes
Drug class classifications
Classified by body systems by how the medication react to certain body systems, or relieves symptoms
Examples are anticoagulant
True, or false drugs can be part of more than one classification
True
What do the last syllables of generic medication indicate?
The last syllables indicate the class
Examples are OLOL, PRIL, TIDINE, PRAZOLE
Generic drug names
Assigned by the manufacturer that first developed the drug, name is lowercase, name can be used by anyone
This is the manufacturers name
Examples are acetaminophen
I drug brand or trade name
Copyrighted by the company that sells the drug
Uppercase
Example Tylenol
Pharmacokinetics
A drug cycle, or the process of how medication gets to the target site and what happens to the medication during the journey
Where is most absorption done in the body?
Muscles or G.I. track
What is absorption?
The process by which a substance moves into the bloodstream from the site where it is administered
True or false sub Q is less absorbing than intramuscular
True 
What factors very absorption rate
Route of administration: topical is the slowest
Ability to dissolve
Blood flow of the area
Body surface
Solubility of the med
Distribution
The delivery of a drug to the appropriate site after the drug has been absorbed into the bloodstream
Factors that affect drug distribution
Circulation
Membrane permeability
Plasma, protein binding
Circulation
The greater the blood supply, the greater the distribution-easier to move drug to the site
Membrane permeability
Drug must be able to cross the cell membrane in order to be distributed
Brain barrier vs. Placental barrier.
Fat soluble can cross this barrier
Plasma, protein binding
once the protein is in the circulation it attaches to plasma proteins, like albumin and decreases the amount of free drug available
Can create toxicity because it’s not getting binded
Liver problem or malnutrition
Metabolism
Is medication reaches the specific site bio transformation occurs under the influence of enzymes, that detoxify, degrade, and then biologically act of chemicals are removed.
The liver is the primary site for drug metabolism
What factors affect drug metabolism?
Age
Genetic
Disease state
Nutritional state
Excretion
The drug is excreted from the body after it is metabolized it exits the body through the kidneys, liver bowel, lungs, or exocrine glands, and respiratory
Kidneys are the main organ for excretion of drugs
Factors that affect the drug action
Developmental considerations-elderly, kids, does calculation by weight
Weight
Genetics and cultural factors differences in metabolizing medication’s, and or tolerance of medication
Psychological factors -state of mind placebo
Pathology -disease, kidney or liver
Environment-noise nutritional state
Timing of administration -empty stomach, food, diuretics
Drug affects are classified as
Local or systemic
Therapeutic effect
The concentration of a drug in the blood serum that produces the desired effect without side effects or toxicity
Intended or desired, physiological response of medication
Therapeutic range
Range between the minimum effect, concentration MEC and toxicity concentration
Side effects
Most drugs have additional effects be on the therapeutic effect on the body. These are generally mild.
Examples are nausea or constipation
Adverse drug affects
Severe side effects that lead to harm or death these are unpredictable
Toxic affects
Occurs when there is a prolonged intake of a medication, or when the medicine accumulates in the body
Example respiratory depression with narcotics opioids
Idiosyncratic effect
Abnormal or peculiar response to a drug that may manifest itself by over response, under response, or different from the expected outcome
Such as an allergic reaction
Symptoms of drug allergy
Uticaria— hives
Eczema
Pruritus— itching
Rhinitis
Wheezing
Anaphylactic shock
Anaphylactic reaction
Respiratory distress
Severe bronchial spasm
Airways close
Cardiovascular shock or collapse
Treatment for anaphylactic shock, or drug allergy
Antihistamine or epinephrine
Drug interactions
Agonist
Synergist
Antagonist 
Agonist
When a drug is taken with another drug, so the two can work together
Synergist
A greater effect than that of each drug alone
Example, ginseng, and Coumadin
Antagonist
When two drugs are taken together, the effect of each is lessened
Example is antibiotics and birth control
Half-life
The time it takes the body to eliminate half the blood concentration level of the drug
The time interval required to reduce the amount of the drug in the body by 50%
Loading dose
A larger than normal, initial dose of a drug to achieve therapeutic affect as quickly as possible
Serum drug level
Serum level can be monitored by drawing a serum blood level after the drug has been administered and has had time to absorb in the body
Onset
Medication effect first begins
Peak
Medication is at its highest concentration or at its peak affect
Duration
How long medication effects last
trough
The lowest serum concentration of a medication before the next medication dose is administer
Teratogenetic drug
Pass placenta barrier
Drug known to cause birth defects
Examples are Accutane for acne and alcohol
Three checks
Always check the medication label with the mar during the three checks
1.When the nurse reaches for the medication
2. Before pouring or opening the medication.
3. When replacing the medication, punch, card or medication, bottle back or before opening the unit at bedside
10 rights
Right client
Right medication
Right dose
Right time,frequency
Right route
Right documentation
Right client education
Right to refuse
Right assessment
Write evaluation
First five rights are always done with the three checks
Right client
Most important nursing intervention* used every time medication is given*
Check ID band
Patient states name and birthdate
Photo ID
NEVER USE ROOM NUMBER
Right medication
Read the medication label and compare it to the MAR three times:
—— before removing the container
—— just before opening and pouring medication
—— immediately prior to administration
Right dose
Compared to average dosages
Metric dosages, containing decimal are of particular concern
Split or crush medication given with pudding or applesauce
Right time
Administer medication‘s in long-term care one hour before or one hour after designated time
Administer medication in acute care. 30 minutes before or 30 minutes after the designated time.
Military time
000 one for one minute after midnight
2359 for one minute before midnight
No duplication in numbers