Intro to Pharmacokinetics

Question 1

Define volume of distribution.

Answer 1

The apparent volume in which a drug is dissolved in the body

Question 2

Write the equation used to work out volume of distribution.

Answer 2

Volume of distribution= dose/conc at t=0

Question 3

What is the bioavailability (F) of a drug?

Answer 3

The fraction of the drug that is absorbed

Question 4

Write the equation for bioavailability.

Answer 4

F= AUC oral/AUC i.v. 
(AUC= area under curve)

Question 5

How can you work out the dose of a drug using bioavailability?

Answer 5

Dose= amount needed/F

Question 6

How can you work out the dose of a drug using Vd?

Answer 6

Dose= Vd x conc at t=0

Question 7

How do you work out the loading dose of a drug?

Answer 7

Loading dose= target plasma concentration x Vd

Question 8

What are the equations for Vd, F, and loading dose?

Answer 8

. Vd= amount in body/conc= dose/conc at t=0
. F= AUC oral/AUC i.v.
. Loading dose= Target plasma conc x Vd

Question 9

What are the equations for working out dose from Vd and from F?

Answer 9

. Dose= Vd x conc at t=0

. Dose= Amount needed/F