Intro to pharm of Inflammation Key Concepts

Question 1

list the 3 physiological signs of

acute inflammation

Answer 1

Vasodilation

Increase in vascular permeability

Accumulation of inflammatory cells

Question 2

What mediators are responsible for Vasodilation

Answer 2

• histamine

- bradykinin

Question 3

What mediators are responsible for Increased vascular permeability

Answer 3

• histamine
• bradykinin
• complement

Question 4

What mediators are responsible for Accumulation of inflammatory cells

Answer 4

• complement
• C reactive protein?
• cytokines: Stimulate acute phase reactants
• Cell Adhesion Molecules: Contributes to recruitment of activated platelets

Question 5

List a major difference in chronic vs acute
inflammation and why therapeutic course
may differ general*

Answer 5

Chronic Inflammation has an auto-amplification loop bc extended amount of inflammation leads to tissue damage which induces more inflammation and it continues.

Treatment is different because chronic inflammation results from several mediators that cause a lot of effects.

Question 6

List the differences between chronic vs. acute inflammation

Answer 6

acute- 
rapid onset: minutes
short duration: hours to a few days 
main characteristic: edema
main cell type: leukocytes, predominantly neutrophils (PMNs) 

chronic-
prolonged duration (weeks or months) 
Main cell type: monocyte 
 Main characteristic: fibrosis

Question 7

What mediators cause fever

Answer 7

• Cytokines

* Prostaglandins

Question 8

What mediators cause Edema

Answer 8

• histamine
• bradykinin
• complement
• Prostaglandins
• Leukotrienes

Question 9

What mediators cause redness

Answer 9

• histamine
• -bradykinin
• -Prostaglandins

Question 10

What mediators cause pain

Answer 10

• Histamine
• Bradykinin
• Prostaglandins

Question 11

What mediators cause loss of function

Answer 11

all if there are too much?

Question 12

why are drugs used in inflammatory

diseases?

Answer 12

Inflammation can cause harmful side effects like tissue damage.