Intro to Pathology Flashcards
Pathology
study of disease
Disease
- any deviation from the normal structure or function
- may/may not have characteristic CS
- may affect whole body or parts
- of known or unknown cause
4 aspects of dz that form the core of pathology
- Etiology
- Pathogenesis
- Molecular & morphologic changes
- Clinical manifestations
Etiology is the
cause
Pathogenesis is the
sequence of events from initial stimulus to ultimate expression of dz
Molecular & morphologic changes
biochemical & structural alterations induced in cells and organs of the body. No longer looks normal
Clinical manifestations
clinical signs resulting from functional abnormalities of affected tissues
The 5 pathological processes
- degeneration/necrosis/cell death
- inflammation & repair/healing
- circulatory disorders
- disorders of growth (neoplasia, cell adaptations, developmental anomalies)
- deposits & pigmentations
General pathology
- the main pathological processes incited by various injurious stimuli
- applies to all cells/tissues/organs
Systemic pathology
- system-SPECIFIC dz processes
- builds on main pathological processes, but takes into account: unique responses to injury of each tissue & specific dz for each system
Diagnosis
concise statement or conclusion concerning the nature, cause, or name or a dz
The outcome predicted
prognosis
Disease name
- aims to encapsulate the host, morphology, and cause of dz
- definitive diagnosis-confirmed using a variety of tests
- differential diagnoses (DDx)
A lesion is
any morphological change (abnormality) in tissues during disease
- lesions caused by disease manifest morphologically as alterations in color, shape, size, texture
- micro/macro
Morphologic diagnosis (MDx)
includes pathological process, location, distribution, duration & severity
