Intro to neurology Flashcards

1
Q

Distinguish between a neurologist and neurology

A

Neurology: problems of the brain, spinal cord and nerves, neuromuscular junction etc.
Neurologist: diagnoses and treats disorders of the nervous system

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2
Q

Describe the incidence of neurology in general practice

A

Stroke Carpal Tunnel Syndrome Epilepsy Bells Palsy Tremor Parkinson’s Disease Brain Tumour Multiple Sclerosis

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3
Q

Describe the prevalence of neurology in the community

A

Migraine Stroke Alzheimer’s Disease Epilepsy Tremor Multiple Sclerosis Chronic Fatigue Syndrome Parkinson’s Disease Unexplained Symptom

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4
Q

Outline an approach for diagnosing neurological problems

A

Use the presenting signs and symptoms to identify the underlying anatomy and characterise the syndrome
•  Use the mode of onset to determine the most likely underlying aetiology (or pathological cause)

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5
Q

Describe the speed of onset of different neurological problems from fast to slow

A

Traumatic •  Vascular •  Toxic/Metabolic •  Infectious •  Inflammatory/Autoimmune •  Genetic-congenital •  Neoplastic •  Degenerativ

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6
Q

Describe history

A

•  Nature of symptoms •  Onset of symptoms •  Previous medical problems •  Family history •  Social history •  Other symptoms

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7
Q

Where could the problem be

A

•  Muscle •  Neuromuscular Junction •  Peripheral Nerve •  Spinal Cord •  Brain

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8
Q

Summarise stroke

A

•  80 % are blockage of a blood vessel (infarct) •  20 % bleeding (haemorrhage) •  Can affect any part of brain (including brainstem) •  Tend to cause problems on the other side to the brain lesion (Contralateral)

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9
Q

Describe the different causes of stroke

A

•  Infarcts often caused by clot from arteries in neck (carotid arteries) •  Haemorrhage often related to high blood pressure •  People who smoke or have family history are at higher risk •  Other risk factors include diabetes and excess alcohol

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10
Q

What do the symptoms of stroke relate to

A
  •   Symptoms related to which artery in the brain is affected
  •   Left side of brain responsible for language so strokes on the left side can cause aphasia
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11
Q

How can strokes affecting different arteries cause different syndromes

A

•  Middle cerebral artery most commonly affected-often results in weakness and loss of sensation on the other side (contralateral) •  Posterior cerebral artery strokes often affect occipital lobe-result in visual loss on the contralateral side •  Anterior cerebral artery strokes often cause contralateral leg weakness

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12
Q

Describe strokes affecting the brainstem

A

Strokes affecting brainstem may cause problems with balance, eye movements, speech and swallowing (Cranial Nerves), breathing
•  Recovery is very variable and can take up to 2 years

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13
Q

Describe stroke treatment

A

Acute – Intravenous Thrombolysis-dissolve the clot – Intra-arterial Thrombectomy-remove clot •  Treat Complications – Neurosurgery for haemorrhage or dangerously high pressure •  Prevent Further Stroke – Thin blood with aspirin – Treat Diabetes and high Cholesterol – Treat dangerously narrow Carotid Arteries

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14
Q

What does the neurological examination consist of

A
  •   Cognitive/thinking abilities: ‘Mini Mental State Examination’
  •   Cranial Nerves-Smell, Vision, Eye movements, Facial sensation and movements
  •   Limbs-Power, Coordination, Reflexes and Sensation
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15
Q

What is Parkinson’s disease

A

Slowly progressive degenerative disease affecting the basal gangli

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16
Q

Describe the clinical features of Parkinson’s

A

The main clinical features are rigidity (stiffness), tremor (shaking) and bradykinesia (reduced movement)
•  There is loss of neurones from the substantia nigra to the caudate and putamen (parts of the basal ganglia)

17
Q

Describe the treatment for Parkinson’s

A

•  The neurotransmitter associated with this is dopamine
•  Patients are treated with levodopa
•  (Dopamine does not cross blood brain barrier but levodopa crosses blood brain barrier and is converted into dopamine)
Can also be treated with electrodes implanted deep into the brain.

18
Q

What are the causes of spastic paraparesis

A

Trauma •  Inflammatory/Autoimmune (eg Multiple Sclerosis) •  Neoplastic (e.g. Spinal Cord Tumour, Metastatic Tumour) •  Degenerative (Motor Neurone Disease) •  Vitamin Deficiency (B12) •  Infection (e.g. Syphilis, Viral) •  Vascular (Anterior Spinal Artery Thrombosis)

19
Q

What is multiple myeloma

A

Tumour of plasma cells

•  Treated with radiotherapy and chemotherapy

20
Q

Describe the causes of acute polyneuropathy

A

Infections eg. Diphtheria •  Autoimmune (eg Guillain Barre Syndrome or Acute Inflammatory Demyelinating Polyneuropathy) •  Drugs (Chemotherapy) •  Exposure to toxins (organophosphate insecticides

21
Q

GBS/AIDP

A

Common cause of acute neuromuscular weakness •  Clinical Diagnosis •  Progressive ascending sensorimotor paralysis with areflexia, affecting 1 or more limbs and reaching nadir within 4 weeks •  Patients may progress to almost complete paralysis and require ventilation

22
Q

Describe the treatment for GBS/AIDP

A
  •   ‘Immunotherapy’-Plasma exchange or intravenous immunoglobulin
  •   Supportive including ventilation if necessary
  •   Cardiac monitoring
  •   Anticoagulation to prevent leg clots (and subsequent pulmonary emboli)
23
Q

Describe the investigations for diagnosing neurological conditions

A
  •   Brain Scans- CT and MRI
  •   Cerebrospinal fluid (CSF) - Lumbar puncture
  •   Nerve Conduction Studies and Electromyography (EMG)
  •   Electroencephalogram (EEG) and Evoked Potentials
  •   Brain pathology – damage to cells or larger structures