Intro to Medical Neuro-Pharmacology

Question 1

Astrocytes Function?

Answer 1

Provide neurons with growth factors.
Remove excess glutamate (excitotoxic NT).
Support BBB

Question 2

Oligodenfrocytes function?

Answer 2

Produce myelin sheath in CNS that insulates axons

Question 3

Microglia function?

Answer 3

“Microglia are the MQ’s of the CNS.”
Provide GFs.
Play role in neural inflammation

Question 4

BBB restricts?…..Using what kind of junctions?

Answer 4

Hydrophilic substances
Microscopic substances (bacteria)
Tight junctions

Question 5

Pericytes role?

Answer 5

Contractile cells that wrap around blood vessels throughout body. In brain they are part of the BBB

Question 6

What substances are allowed to cross the BBC

Answer 6

Hydrophobic substances (hormones, gases)
Metabolic products (Glucose)

Question 7

Neural transmission/release of NTs is triggered by? Influx of ?

Answer 7

Depolarization, Na+

Question 8

Depolarization is _________While polarization is_______

Answer 8

Excitatory

Inhibitory

Question 9

Every neuron action potential has the same_______

Answer 9

Magnitude

Question 10

Current carried by a nerve fiber (bundle of axons) is greater due to the result of ___________

Answer 10

Summation

Question 11

Acetylcholine binds a__________ and _________receptor

Answer 11

Nicotinic (nAChR)

Muscarinic (mAChR)

Question 12

Dopamine binds D1 and D2 GPCRs. D1 is ______coupled and D2 is_______ coupled.

Answer 12

Gs

Gi

Question 13

Norepinephrine is secreted by the_____________and binds___________

Answer 13

Locus Coeruleus

a1 and a2 (Adrenergic GCPRs)

Question 14

Serotonin binds__________ receptors

Answer 14

5-HT receptors

Question 15

5-HT3 receptor is a___________while 5-HT1,2 are________

Answer 15

Ion channel (Na+-Influx)==> Excitatory
GPCRs

Question 16

Serotonin transmission is involved in________

Answer 16

Depression,
Mood disorders/anxiety
Schizophrenia

Question 17

GABA transmission is involved in________

Answer 17

Epilepsy
Spasticity
Addiction

Question 18

GABA binds channels_________?

Answer 18

GABA A,B,C

Question 19

GABA A is a ______________While GABA B,C are ___________

Answer 19

Ion channel(Cl- influx)==> Inhibitory
GPCRs

Question 20

Glutamate binds_____________

Answer 20

AMPA
NMDA (ion channel)
mGluR(GPCR)

Question 21

Serotonin is secreted from the____________

Answer 21

Raphe Nuclei

Question 22

GABA is involved in________

Answer 22

Epilepsy
Spasticity
Addiction/Alcohol

Question 23

Glutamate binds to___________

Answer 23

AMPA
NMDA
mGluR

Question 24

The glutamate AMPA receptor is a_________

Answer 24

Ion channel

Question 25

The mGluR of glutamate is a ____________

Answer 25

GPCR

Question 26

Ionotropic channels have a_______response while GPCRs have a __________response

Answer 26

Fast | Slow

Question 27

GPCRs have a ____________but ________response

Answer 27

Slow | Long-lived

Question 28

In voltage gated channels, Na+, Ca++ and Cl- enable thier respective______________during depolarixation while K+ Voltage gated channel enables K+__________

Answer 28

Efflux

Question 29

What is the function of NT transporters? Where are they located?

Answer 29

Terminate synaptic transmission. | Found in Presynaptic neuron (usually)

Question 30

Where do Drugs normally act at the synapse?

Answer 30

``` NT synthesis NT storage NT reuptake Autoreceptors Presynaptic receptors ```

Question 31

Kd represents?

Answer 31

Affinity of a drug for it's receptor.

Question 32

What does a low Kd mean?What does a High Kd mean?

Answer 32

High Kd means low drug affinity a low Kd means high binding affinity.

Question 33

What is Bmax?

Answer 33

It's an estimate of the density/number of receptors.

Question 34

Ki represents?

Answer 34

Indirect assessment of drug receptor affinity. It stands for the inhibitory constant. It's the amount (Conc.) of Drug required to inhibit a CYP450 enzyme by 50%