Intro to Medical Neuro-Pharmacology

Question 1

Astrocytes Function?

Answer 1

Provide neurons with growth factors.
Remove excess glutamate (excitotoxic NT).
Support BBB

Question 2

Oligodenfrocytes function?

Answer 2

Produce myelin sheath in CNS that insulates axons

Question 3

Microglia function?

Answer 3

“Microglia are the MQ’s of the CNS.”
Provide GFs.
Play role in neural inflammation

Question 4

BBB restricts?…..Using what kind of junctions?

Answer 4

Hydrophilic substances
Microscopic substances (bacteria)
Tight junctions

Question 5

Pericytes role?

Answer 5

Contractile cells that wrap around blood vessels throughout body. In brain they are part of the BBB

Question 6

What substances are allowed to cross the BBC

Answer 6

Hydrophobic substances (hormones, gases)
Metabolic products (Glucose)

Question 7

Neural transmission/release of NTs is triggered by? Influx of ?

Answer 7

Depolarization, Na+

Question 8

Depolarization is _________While polarization is_______

Answer 8

Excitatory

Inhibitory

Question 9

Every neuron action potential has the same_______

Answer 9

Magnitude

Question 10

Current carried by a nerve fiber (bundle of axons) is greater due to the result of ___________

Answer 10

Summation

Question 11

Acetylcholine binds a__________ and _________receptor

Answer 11

Nicotinic (nAChR)

Muscarinic (mAChR)

Question 12

Dopamine binds D1 and D2 GPCRs. D1 is ______coupled and D2 is_______ coupled.

Answer 12

Gs

Gi

Question 13

Norepinephrine is secreted by the_____________and binds___________

Answer 13

Locus Coeruleus

a1 and a2 (Adrenergic GCPRs)

Question 14

Serotonin binds__________ receptors

Answer 14

5-HT receptors

Question 15

5-HT3 receptor is a___________while 5-HT1,2 are________

Answer 15

Ion channel (Na+-Influx)==> Excitatory
GPCRs

Question 16

Serotonin transmission is involved in________

Answer 16

Depression,
Mood disorders/anxiety
Schizophrenia

Question 17

GABA transmission is involved in________

Answer 17

Epilepsy
Spasticity
Addiction

Question 18

GABA binds channels_________?

Answer 18

GABA A,B,C

Question 19

GABA A is a ______________While GABA B,C are ___________

Answer 19

Ion channel(Cl- influx)==> Inhibitory
GPCRs

Question 20

Glutamate binds_____________

Answer 20

AMPA
NMDA (ion channel)
mGluR(GPCR)

Question 21

Serotonin is secreted from the____________

Answer 21

Raphe Nuclei

Question 22

GABA is involved in________

Answer 22

Epilepsy
Spasticity
Addiction/Alcohol

Question 23

Glutamate binds to___________

Answer 23

AMPA
NMDA
mGluR

Question 24

The glutamate AMPA receptor is a_________

Answer 24

Ion channel

Question 25

The mGluR of glutamate is a ____________

Answer 25

GPCR

Question 26

Ionotropic channels have a_______response while GPCRs have a __________response

Answer 26

Fast

Slow

Question 27

GPCRs have a ____________but ________response

Answer 27

Slow

Long-lived

Question 28

In voltage gated channels, Na+, Ca++ and Cl- enable thier respective______________during depolarixation while K+ Voltage gated channel enables K+__________

Answer 28

Efflux

Question 29

What is the function of NT transporters? Where are they located?

Answer 29

Terminate synaptic transmission.

Found in Presynaptic neuron (usually)

Question 30

Where do Drugs normally act at the synapse?

Answer 30

NT synthesis
NT storage
NT reuptake
Autoreceptors
Presynaptic receptors

Question 31

Kd represents?

Answer 31

Affinity of a drug for it’s receptor.

Question 32

What does a low Kd mean?What does a High Kd mean?

Answer 32

High Kd means low drug affinity a low Kd means high binding affinity.

Question 33

What is Bmax?

Answer 33

It’s an estimate of the density/number of receptors.

Question 34

Ki represents?

Answer 34

Indirect assessment of drug receptor affinity. It stands for the inhibitory constant. It’s the amount (Conc.) of Drug required to inhibit a CYP450 enzyme by 50%